Left ventricular remodelling index (LVRI) in various pathophysiological conditions: a real-time three-dimensional echocardiographic study

Abstract

Background: Various studies have reported a close correlation between real-time three-dimensional echocardiography (RT3DE) and cine magnetic resonance imaging studies for the assessment of cardiac volumes and mass. Objective: The aim of our study was to evaluate changes in left ventricular volumes and mass in subjects with different pathophysiological conditions. A ratio between left ventricular mass and end-diastolic volume (LVRI), detected by RT3DE, was used to describe various patterns of left ventricular remodelling. Methods: RT3DE was performed to calculate left ventricular end-diastolic (LVEDV) and end-systolic volume (LVESV), ejection fraction (LVEF) and mass in 220 selected subjects. Of these, 152 were healthy volunteers, 19 top-level rowers, 23 patients with dilated cardiomyopathy and 26 patients with hypertrophic cardiomyopathy. Off-line analysis was performed by two independent operators by tracing manual endocardial and epicardial borders of the left ventricle through eight cutting planes. Inter-and intra-observer variability were calculated. Results: Despite the increase in LV volume and mass in the rowers, LVRI remained unchanged compared with control subjects (p = 0.455), while significantly lower values were found patients with dilated cardiomyopathy (p,0.001) and significantly higher values in patients with hypertrophic cardiomyopathy (p,0.001). There was inter-and intra-observer variability. Conclusion: The LVRI may serve as a simple and useful indicator of left ventricular adaptation to physiological and pathological conditions.

Endogenous α‐calcitonin‐gene‐related peptide promotes exercise‐induced, physiological heart hypertrophy in mice

“…In these latter mice the myocardial volume remained unchanged whereas the remodeling index decreased significantly (Fig. 2d & 2e), which characterizes cardiac maladaptation (De Castro et al, 2007). Unfortunately, assessing cardiac function directly was not possible, Hence, we do not know whether altered diastolic or systolic functions or both accompany the differences in exercise performance or heart geometry observed in the various experimental groups.…”

Tomographic Left Ventricular Volumetric Emptying Analysis by Real-Time 3-Dimensional Echocardiography

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Impact of Functional, Morphological and Clinical Parameters on Epicardial Adipose Tissue in Patients With Coronary Artery Disease

“…The LV remodelling index (LVRI) was determined as the ratio of LV mass (LV-EDMI) to LV end-diastolic volume (LV-EDV). 20 Additionally, left and right ventricular diameters were measured. On the 4-chamber view, the distance between the cutting edge of the tricuspid annulus with the RV free wall and the RV apex was measured in end-diastole (end-diastolic length, EDL, mm) and end-systole (ESL, mm), and the right ventricular fractional shortening (RVFS) was calculated as follows:…”