Left Ventricular Performance in Patients With Severe Acute Respiratory Syndrome

Li, Steven Siu Lung; Cheng, Cheung Wah Boron; Fu, Chiu Lai; Chan, Yiu Han; Lee, Man Po; Chan, Johnny Wai Man; Yiu, Siu Fung

doi:10.1161/01.cir.0000094737.21775.32

Cited by 200 publications

(184 citation statements)

References 18 publications

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“…Given the relatively well-preserved lung function in the majority of our SARS survivors, the poor performance in the 6MWT in most age groups could be due to additional factors such as muscle wasting, myopathy, and possibly cardiac diastolic dysfunction. 50 Lau et al 51 noted that muscle strength and endurance were more impaired in proximal than in distal muscles among survivors in our SARS cohort at 3 months after illness onset. Eighteen of 44 SARS survivors in Singapore had reduced exercise capacity at 3 months after hospital discharge that could not be accounted for by impairment of pulmonary function.…”

Section: Discussionmentioning

confidence: 55%

The 1-Year Impact of Severe Acute Respiratory Syndrome on Pulmonary Function, Exercise Capacity, and Quality of Life in a Cohort of Survivors

Hui

Wong

et al. 2005

Chest

321

288

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Section: Discussionmentioning

confidence: 55%

The 1-Year Impact of Severe Acute Respiratory Syndrome on Pulmonary Function, Exercise Capacity, and Quality of Life in a Cohort of Survivors

Hui

Wong

et al. 2005

Chest

321

288

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“…However, extrapulmonary manifestations are not uncommon. Skin rash [4], petechial cutaneous bleeding with prolonged activated partial thromboplastin time and increased d-dimer [12], impaired liver function, subclinical left ventricular diastolic dysfunction [13], and rhabdomyolysis [14] were occasionally reported. One of the more common presentations other than respiratory symptoms is diarrhea [4,7,9,[15][16][17][18].…”

Section: Discussionmentioning

confidence: 99%

Viral Replication in the Nasopharynx Is Associated with Diarrhea in Patients with Severe Acute Respiratory Syndrome

et al. 2004

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The role of severe acute respiratory syndrome (SARS) coronavirus as an enteric pathogen was investigated in a cohort of 142 patients with SARS who were treated with a standard treatment protocol. Data from daily hematological, biochemical, radiological, and microbiological investigations were prospectively collected, and the correlation of these findings with diarrhea was retrospectively analyzed. Sixty-nine patients (48.6%) developed diarrhea at a mean (+/- standard deviation [SD]) of 7.6+/-2.6 days after the onset of symptoms. The diarrhea was most severe at a mean (+/-SD) of 8.8+/-2.4 days after onset, with a maximum frequency of 24 episodes per day (median, 5 episodes; range, 3-24 episodes). A higher mean virus load in nasopharyngeal specimens obtained on day 10 after the onset of symptoms was significantly associated with the occurrence of diarrhea (3.1 log10 vs. 1.8 log10 copies/mL; P=.01) and mortality (6.2 vs. 1.7 log10 copies/mL; P<.01). However, diarrhea was not associated with mortality. The lung and the gastrointestinal tract may react differently to SARS coronavirus infection. Additional investigation of the role of SARS coronavirus in the pathogenesis of diarrhea in patients with SARS should be conducted.

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“…Moreover, our own studies have implicated the involvement of the RAS in SARS pathogenesis: first, ACE2 is a critical SARS receptor in vivo and, second, ACE2 and other components of the RAS play a central role in controlling the severity of acute lung failure once the disease process has started [13]. Intriguingly, before the identification of ACE2 as a SARS receptor, it has been reported that some SARS patients develop impaired heart contractility using echocardiograhic measurements [65]. Certainly, the observed decrease in left ventricular performance during the acute infection phase may be related to a systemic inflammatory condition [66], which is not unique to SARS.…”

Section: Ace2 In Sars Pathologymentioning

confidence: 99%

Lessons from SARS: control of acute lung failure by the SARS receptor ACE2

et al. 2006

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Angiotensin-converting enzyme 2 (ACE2), a second angiotensin-converting enzyme (ACE), regulates the renin-angiotensin system by counterbalancing ACE activity. Accumulating evidence in recent years has demonstrated a physiological and pathological role of ACE2 in the cardiovascular systems. Recently, it has been shown that severe acute respiratory syndrome (SARS) coronavirus, the cause of SARS, utilizes ACE2 as an essential receptor for cell fusion and in vivo infections in mice. Intriguingly, ACE2 acts as a protective factor in various experimental models of acute lung failure and, therefore, acts not only as a key determinant for SARS virus entry into cells but also contributes to SARS pathogenesis. Here we review the role of ACE2 in disease pathogenesis, including lung diseases and cardiovascular diseases.

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Left Ventricular Performance in Patients With Severe Acute Respiratory Syndrome

Abstract: Subclinical diastolic impairment without systolic involvement was observed in patients with SARS. This impairment may be reversible on clinical recovery.

Cited by 200 publications

References 18 publications

The 1-Year Impact of Severe Acute Respiratory Syndrome on Pulmonary Function, Exercise Capacity, and Quality of Life in a Cohort of Survivors

The 1-Year Impact of Severe Acute Respiratory Syndrome on Pulmonary Function, Exercise Capacity, and Quality of Life in a Cohort of Survivors

Viral Replication in the Nasopharynx Is Associated with Diarrhea in Patients with Severe Acute Respiratory Syndrome

Lessons from SARS: control of acute lung failure by the SARS receptor ACE2

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