Left ventricular myocardial deformation abnormalities in seizure-free children with epilepsy

Çelik, Şenol; Güven, Ahmet Sami; Torun, Yasemin Altuner

doi:10.1016/j.seizure.2018.08.017

Cited by 9 publications

(14 citation statements)

References 35 publications

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“…These studies showed a reduction in tissue Doppler E’ velocity consistent with our results. More significantly, our results are consistent with the results of the only other comparable study of advanced echocardiography and deformation in pediatric epilepsy patients 16 . These include normal EF and SF, impaired measures of systolic deformation, and impaired diastolic parameters as measured by mitral inflow and tissue Doppler velocities.…”

Section: Discussionsupporting

confidence: 91%

“…More significantly, our results are consistent with the results of the only other comparable study of advanced echocardiography and deformation in pediatric epilepsy patients. 16 These include normal EF and SF, impaired measures of systolic deformation, and impaired diastolic parameters as measured by mitral inflow and tissue Doppler velocities. Notably, the details of our subjects' epilepsy histories were not correlated with echocardiographic data.…”

Section: Discussionmentioning

confidence: 99%

“…14,15 Recently, Çelik et al evaluated pediatric patients with well-controlled epilepsy on monotherapy and found differences in strain as well as other secondary measures of cardiac function compared to controls. 16 However, such an analysis has not been performed in patients with refractory epilepsy, and it is not known how the deformation parameters or other echocardiographic differences would compare in this group.…”

Section: Introductionmentioning

confidence: 99%

“…Strain has been evaluated in many disease states in adult and pediatric populations and may be more sensitive to early myocardial damage than traditional measures of systolic and diastolic function 14,15 . Recently, Çelik et al evaluated pediatric patients with well‐controlled epilepsy on monotherapy and found differences in strain as well as other secondary measures of cardiac function compared to controls 16 . However, such an analysis has not been performed in patients with refractory epilepsy, and it is not known how the deformation parameters or other echocardiographic differences would compare in this group.…”

Section: Introductionmentioning

confidence: 99%

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Children with refractory epilepsy demonstrate alterations in myocardial strain

et al. 2020

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Objective: To test whether children with epilepsy have impairments in myocardial mechanics compared to controls without epilepsy. Methods: Children with refractory epilepsy with epilepsy duration of at least 3 years underwent echocardiography including conventional measurements and speckle tracking to assess longitudinal and circumferential strain. Parent-completed surveys, capturing critical aspects of the children's seizure history and cardiac risk factors, complemented retrospective chart reviews, which also included antiepileptic drug history. Normal echocardiograms from controls, matched for age and gender, were obtained from our institutional database and evaluated for strain. Results: Forty-one patients (median age = 10 years, interquartile range [IQR] = 5-15; 58.5% male) were enrolled. Epilepsy etiology included genetic (n = 26), structural (n = 6), genetic and structural (n = 5), infection (n = 3), and unknown (n = 1). No cardiac structural abnormalities were identified. Both longitudinal and circumferential strain were impaired (P < .03) in patients compared to controls (median [IQR] = 22.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Children with refractory epilepsy demonstrate alterations in myocardial strain

et al. 2020

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“… 19 , 20 Concerning mechanical dysfunction, recent studies demonstrated a reduced systolic and diastolic function in individuals with epilepsy, without evidence of a correlation between the echocardiographic findings and the severity of epilepsy. 21 , 22 Cardiac fibrosis and vascular dysfunction contribute to altering cardiac conduction and repolarization, thus generating a substrate for the development of arrhythmias. 23 Finally, as a result of the structural, functional, and electrical anomalies, a higher incidence of myocardial infarction (4.83‐fold increase) in epileptic individuals compared to the general population has been demonstrated.…”

Section: Epilepsy and Cardiac Comorbiditiesmentioning

confidence: 99%

The brain–heart interaction in epilepsy: implications for diagnosis, therapy, and SUDEP prevention

Costagliola

Orsini

Coll

et al. 2021

Ann Clin Transl Neurol

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The influence of the central nervous system and autonomic system on cardiac activity is being intensively studied, as it contributes to the high rate of cardiologic comorbidities observed in people with epilepsy. Indeed, neuroanatomic connections between the brain and the heart provide links that allow cardiac arrhythmias to occur in response to brain activation, have been shown to produce arrhythmia both experimentally and clinically. Moreover, seizures may induce a variety of transient cardiac effects, which include changes in heart rate, heart rate variability, arrhythmias, asystole, and other ECG abnormalities, and can trigger the development of Takotsubo syndrome. People with epilepsy are at a higher risk of death than the general population, and sudden unexpected death in epilepsy (SUDEP) is the most important direct epilepsy-related cause of death. Although the cause of SUDEP is still unknown, cardiac abnormalities during and between seizures could play a significant role in its pathogenesis, as highlighted by studies on animal models of SUDEP and registration of SUDEP events. Recently, genetic mutations in genes co-expressed in the heart and brain, which may result in epilepsy and cardiac comorbidity/increased risk for SUDEP, have been described. Recognition and a better understanding of brainheart interactions, together with new advances in sequencing techniques, may provide new insights into future novel therapies and help in the prevention of cardiac dysfunction and sudden death in epileptic individuals.

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The epileptic heart: Cardiac comorbidities and complications of epilepsy. Atrial and ventricular structure and function by echocardiography in individuals with epilepsy – From clinical implications to individualized assessment

Loureiro Fialho,

Miotto,

Tatsch Cavagnollo

et al. 2024

Epilepsy & Behavior Reports

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Left ventricular myocardial deformation abnormalities in seizure-free children with epilepsy

Abstract: In seizure-free patients, cardiac systolic and diastolic functions were impaired when compared to healthy children. There was no difference in the patient group to explain the decline in cardiac functions and there may be unknown different factors besides the known risk factors.

Cited by 9 publications

References 35 publications

Children with refractory epilepsy demonstrate alterations in myocardial strain

Children with refractory epilepsy demonstrate alterations in myocardial strain

The brain–heart interaction in epilepsy: implications for diagnosis, therapy, and SUDEP prevention

The epileptic heart: Cardiac comorbidities and complications of epilepsy. Atrial and ventricular structure and function by echocardiography in individuals with epilepsy – From clinical implications to individualized assessment

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