Left ventricular metastasis of soft tissue sarcoma causing heart failure: Presentation of two cases

Obstructive Cardiac Tumors

“…26 There are numerous case reports of metastases causing ventricular outflow tract obstruction related to neoplasms of several primary sites, such as soft tissue sarcoma, lymphoma, leukemia, liposarcoma, ovary carcinoma, renal cell adenocarcinoma, hepatic tumors, pancreatic and colorectal adenocarcinoma, and even squamous cell carcinoma of the base of the mouth. 24,25,[27][28][29][30] Although less common, there are reports of left ventricular inflow (Figure 5) and outflow obstruction in individuals with synovial sarcoma of the foot and grade III pleomorphic leiomyosarcoma, both undergoing treatment with chemotherapy and radiation therapy and evolving to death after 3 and 6 months. 27 The main manifestation of left ventricular obstruction is progressive dyspnea.…”

“…24,25,[27][28][29][30] Although less common, there are reports of left ventricular inflow (Figure 5) and outflow obstruction in individuals with synovial sarcoma of the foot and grade III pleomorphic leiomyosarcoma, both undergoing treatment with chemotherapy and radiation therapy and evolving to death after 3 and 6 months. 27 The main manifestation of left ventricular obstruction is progressive dyspnea. The masses can infiltrate ventricular wall and advance to the outflow tract, causing flow restriction.…”

“…The prognosis is usually poor, with death occurring in less than 6 months. 25,[27][28][29]31,33 Primary cardiac tumors Cardiac tumors are rare (0.001% to 0.3%, according to pathological studies), and are classified as benign or malignant, and as primary or secondary (metastatic).…”