Left-ventricular mechanics in children with hypertrophic cardiomyopathy. CMR study

Mazurkiewicz, Łukasz; Ziółkowska, Lidia; Petryka, Joanna; Śpiewak, Mateusz; Małek, Łukasz A.; Kubik, Agata; Marczak, Magdalena; Miśko, Jolanta; Brzezińska‐Rajszys, Grażyna

doi:10.1016/j.mri.2017.07.003

Cited by 8 publications

(9 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous reports have concentrated on LV global longitudinal myocardial strain (GLS), which has been shown to be associated with ventricular arrhythmia and poor cardiac outcomes, especially heart failure, and to be an independent parameter that can potentially be used for cardiovascular risk assessment 23‐25 . LV global myocardial strain and strain rate have been shown to be significantly different between juvenile HCM patients with and without obstruction 16 and small studies have shown differences in LV endocardial global strain and LVOT area in adults 26,27 . Other small studies have not shown global myocardial strain differences between patients with and without obstruction 17,28 .…”

Section: Discussionmentioning

confidence: 99%

“…Tissue tracking (or feature tracking) is a recently developed technology that uses routinely acquired cine images and can segmentally analyze myocardial mechanics to produce measurements of strain, strain rate, and displacement in the radial, circumferential, and longitudinal directions 15 . LVOT obstruction may have a significant correlation with LV myocardial mechanics and this has been reported by MR feature tracking analysis in children 16 . However, LV myocardial strain in adult obstructive and nonobstructive HCM is poorly understood.…”

mentioning

confidence: 85%

Section: Methodsmentioning

confidence: 99%

“…MR image analysis was performed with commercial postprocessing software (cvi42 v5.11, Circle Cardiovascular Imaging, Alberta, Canada), which was widely used in cardiac studies and confirmed to be highly reproducible for measurements. 16,19 MR cine images were input to the Tissue Tracking module for LV evaluation according to the 16 AHA segmentation model. 20 Endocardial and epicardial boundaries were automatically traced in the systolic and diastolic phases of the LV, while pericardium, blood pool, and papillary muscle were carefully excluded manually (Fig.…”

Section: Image Analysismentioning

confidence: 99%

“…15 LVOT obstruction may have a significant correlation with LV myocardial mechanics and this has been reported by MR feature tracking analysis in children. 16 However, LV myocardial strain in adult obstructive and nonobstructive HCM is poorly understood. Thus, the purpose of our study was to investigate whether LV myocardial strain based on tissue tracking can provide a convenient and reliable approach to identify LVOT obstruction in adult HCM patients.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Left Ventricular Outflow Tract Obstruction in Hypertrophic Cardiomyopathy: The Utility of Myocardial Strain Based on Cardiac MR Tissue Tracking

She

Guo

et al. 2020

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Background: Myocardial strain for assessment of hypertrophic cardiomyopathy (HCM) is of importance and may play a role in identifying obstruction in HCM patients. Purpose: To evaluate the utility of myocardial strain for detecting left ventricular (LV) outflow tract (LVOT) obstruction in HCM patients based on magnetic resonance tissue tracking. Study Type: Retrospective. Population: In all, 44 adult HCM patients with LVOT obstruction and 108 adult HCM patients without LVOT obstruction. Field Strength/Sequence: 1.5 T; Steady-state free-precession cine sequence; phase-sensitive inversion-prepared segmented gradient echo sequence for late gadolinium enhancement (LGE) imaging. Assessment: Strain parameters including the local and global levels of LV myocardium and the subtraction (Sub) of myocardial strain variables between interventricular septal segments (IVSS) and noninterventricular septal segments (NIVSS) were measured for differentiating HCM with obstruction from nonobstruction. Average and maximum LV wall thickness (Average and Maximum LVWT) were also analyzed. Statistical Tests: Univariate and multivariate logistic regression analysis, area under the receiver operating characteristic (ROC) curve (AUC), intraclass correlation coefficient. Results: In multivariate analysis, Average LVWT, Maximum LVWT, and the subtraction of radial peak strain (Sub Radial PS) between NIVSS and IVSS were independently associated with LVOT obstruction. The AUCs were 0.731, 0.840, and 0.890 for Average LVWT, Maximum LVWT, and Sub Radial PS, respectively. Sub Radial PS (cutoff value: 8.1%) demonstrated the highest sensitivity of 75.0% and a high specificity of 87.9% for identifying LVOT; Maximum LVWT (cutoff value: 22.9 mm) showed good sensitivity (72.7%) and specificity (83.3%). Combining Maximum LVWT >22.9 mm and Sub Radial PS > 8.1% achieved a better diagnostic performance (specificity 95.4%, sensitivity 70.5%). Data Conclusion: Combining Maximum LVWT >22.9 mm and Sub Radial PS >8.1% holds promise for objectively evaluating LVOT obstruction in HCM patients with very high specificity and acceptable sensitivity. Level of Evidence: 3 Technical Efficacy Stage: 2

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 85%

Section: Methodsmentioning

confidence: 99%

Section: Image Analysismentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Left Ventricular Outflow Tract Obstruction in Hypertrophic Cardiomyopathy: The Utility of Myocardial Strain Based on Cardiac MR Tissue Tracking

She

Guo

et al. 2020

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

Altered regional myocardial velocities by tissue phase mapping and feature tracking in pediatric patients with hypertrophic cardiomyopathy

Ruh

Berhane

et al. 2019

Pediatr Radiol

View full text Add to dashboard Cite

Background-Hypertrophic cardiomyopathy (HCM) is associated with heart failure, atrial fibrillation and sudden death. Reduced myocardial function has been reported in HCM despite normal left ventricular (LV) ejection fraction. Additionally, LV fibrosis is associated with elevated T1 and might be an outcome predictor.Objective-To systematically compare tissue phase mapping and feature tracking for assessing regional LV function in children and young adults with HCM and pediatric controls, and to evaluate structure-function relationships among myocardial velocities, LV wall thickness and myocardial T1.Materials and methods-Seventeen pediatric patients with HCM and 21 age-matched controls underwent cardiac MRI including standard cine imaging, tissue phase mapping (two-dimensional cine phase contrast with three-directional velocity encoding), and modified Look-Locker inversion Terms of use and reuse: academic research for non-commercial purposes, see here for full terms. http://www.springer.com/gb/openaccess/authors-rights/aam-terms-v1

show abstract

Detecting Regional Fibrosis in Hypertrophic Cardiomyopathy: The Utility of Myocardial Strain Based on Cardiac Magnetic Resonance

et al. 2023

View full text Add to dashboard Cite

Left-ventricular mechanics in children with hypertrophic cardiomyopathy. CMR study

Cited by 8 publications

References 45 publications

Left Ventricular Outflow Tract Obstruction in Hypertrophic Cardiomyopathy: The Utility of Myocardial Strain Based on Cardiac MR Tissue Tracking

Left Ventricular Outflow Tract Obstruction in Hypertrophic Cardiomyopathy: The Utility of Myocardial Strain Based on Cardiac MR Tissue Tracking

Altered regional myocardial velocities by tissue phase mapping and feature tracking in pediatric patients with hypertrophic cardiomyopathy

Detecting Regional Fibrosis in Hypertrophic Cardiomyopathy: The Utility of Myocardial Strain Based on Cardiac Magnetic Resonance

Contact Info

Product

Resources

About