Left ventricular mass normalization for body size in children based on an allometrically adjusted ratio is as accurate as normalization based on the centile curves method

Krysztofiak, Hubert; Młyńczak, Marcel; Małek, Łukasz A.; Folga, Andrzej; Braksator, Wojciech

doi:10.1371/journal.pone.0225287

Cited by 5 publications

(6 citation statements)

References 34 publications

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“…It is consistent with the results of our previous studies [17,18], and the presence of a significant relationship between LVM indexed to height raised to the power of 2.7 and height in girls additionally confirms the results of the current work.…”

Section: Plos Onesupporting

confidence: 93%

“…For each set of data, the sex-specific z-scores were displayed against the non-specific ones. Besides, a line of equality was drawn on the graph as well as one horizontal line and one vertical line at LVM z-score equal to +1.65, indicating the limit for diagnosis of LV hypertrophy [18,38].…”

Section: Methods For Comparison Of Sex-specific and Non-specific Lvm Nmentioning

confidence: 99%

“…Finally, one set was developed based on the ratio of LVM to the allometrically adjusted height according to the method proposed in our previous study [18]. Based on the bivariate relationship between LVM and height, an allometric exponent for the combined group and then two distinct allometric exponents for girls and boys were determined respectively.…”

Section: Development Of Sex-specific and Non-specific Lvm Normative Datamentioning

confidence: 99%

“…The LVM normative data preparation and calculation of individual z-scores were made in the same way as for the ratio of LVM to the allometrically adjusted BSA and the commonly used LVM indices. Examples of LVM z-score calculations from the L, M, and S values corresponding to the body size parameter's magnitude, and based on the mean and standard deviation of LVM indices, were presented in a supporting file in our previous article [18].…”

Section: Development Of Sex-specific and Non-specific Lvm Normative Datamentioning

confidence: 99%

“…To diagnose or manage LVH, actual LVM normalized for body size has to be compared to properly developed normative data. In our recent studies, we analyzed a problem of the correct body size variable for cardiac LVM normalization [17] and the issue of an accurate and convenient method for cardiac size scaling [18]. In previous studies, we developed normative data for children and adolescents practicing sport and compared them to the normative data generated for the general pediatric population [19,20].…”

Section: Introductionmentioning

confidence: 99%

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Left ventricular mass normalization in child and adolescent athletes must account for sex differences

et al. 2020

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Background To assess left ventricular hypertrophy, actual left ventricular mass (LVM) normalized for body size has to be compared to the LVM normative data. However, only some published normative echocardiographic data have been produced separately for girls and boys; numerous normative data for the pediatric population are not sex-specific. Thus, this study aimed to assess whether the LVM normative data should be developed separately for girls and boys practicing sports. Methods Left ventricular mass was computed for 331 girls and 490 boys, 5-19 years old, based on echocardiography. The effect of sex on the relationship between LVM and body size was evaluated using a linear regression model. Seven sets of the LVM normative data were developed, using different methodologies, to test concordance between sex-specific and non-specific normative data. Every set consisted of normative data that was sex-specific and non-specific. Upon these normative data, for every study participant, seven pairs of LVM z-scores were calculated based on her/his actual LVM. Each pair consisted of z-scores computed based on sex-specific and non-specific normative data from the same set. Results The regression lines fitted to the data points corresponding to LVM of boys had a higher slope than of girls, indicating that sex affects the relationship between LVM and body size. The mean differences between the paired LVM z-scores differed significantly from 0. The percentage of discordant indications, depending on the normalization method, ranged from 66.7% to 100% in girls and from 35.4% to 50% in boys. Application of the LVM normative

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Section: Plos Onesupporting

confidence: 93%

Section: Methods For Comparison Of Sex-specific and Non-specific Lvm Nmentioning

confidence: 99%

Section: Development Of Sex-specific and Non-specific Lvm Normative Datamentioning

confidence: 99%

Section: Development Of Sex-specific and Non-specific Lvm Normative Datamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Left ventricular mass normalization in child and adolescent athletes must account for sex differences

et al. 2020

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Results of daily monitoring among adolescents with different forms of arterial hypertension

Cam¹,

Hoang²,

Le³

2021

Progress in Pediatric Cardiology

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Predicting the risk of left ventricular hypertrophy in children and adolescents with arterial hypertension on the basis of 24-hour blood pressure monitoring and metabolism indicators

Haiduk

Gubar

2020

jimsa

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Objective: To investigate the significance of 24-hr ambulatory blood pressure monitoring (ABPM) data and metabolism indicators, as well their correlation in predicting the risk of left ventricular hypertrophy (LVH) in children and adolescents with arterial hypertension (AH). Methods: We studied 118 children and adolescents, M±m 15.51±0.25 yrs, Boys/Girls – 104/14, with AH: 60 stable, 40 labile, 18 prehypertension (high-normal blood pressure), and a control group of 13 normotensive children, M±m 15,19±0,41 yrs, Boys/Girls – 10/3. All patients underwent a comprehensive anamnestic, clinical, laboratory, and instrumental examination, including 24-hr ABPM; indicators were standardized by gender and age. On Doppler echocardiography (echoCG), the left ventricular myocardial mass index (LVMI) was calculated. Lipid spectrum parameters were determined by biochemical method, venous blood glycemia by GOD-PAP, blood serum basal immunoreactive insulin by ELISA methods, insulin resistance (IR) by HOMA parameters calculation. Statistical processing was performed using the package of statistical analysis software STATISTICA. Results: Of a range of metabolism indicators, BMI, TG level, LDL/HDL ratio, HOMA index, 24-hr DBP index, and the stable character of AH identified as the most significant factors in predicting the risk of LVH in hypertensive children. All multivariate models of logistic regressions, which include BMI, can predict the probability of LVH with an accuracy of 79.7-84.7%, sensitivity - 57.5-77.5%, specificity - 86.4-91.0%. Conclusions: Obtained satisfactory concordance of the actual data with predictive models' results indicate the possibility of their use to predict the risk of LVH in children and adolescents with AH.

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Left ventricular mass normalization for body size in children based on an allometrically adjusted ratio is as accurate as normalization based on the centile curves method

Cited by 5 publications

References 34 publications

Left ventricular mass normalization in child and adolescent athletes must account for sex differences

Left ventricular mass normalization in child and adolescent athletes must account for sex differences

Results of daily monitoring among adolescents with different forms of arterial hypertension

Predicting the risk of left ventricular hypertrophy in children and adolescents with arterial hypertension on the basis of 24-hour blood pressure monitoring and metabolism indicators

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