Left ventricular mass index and ventricular contractility improvement in patients with severe obesity following rapid weight loss after bariatric surgery

Sarmiento-Cobos, Mauricio; Rivera, Carlos; Okida, Luis Felipe; Cogollo, Vicente J.; Montorfano, Lisandro; Blanco, David Gutierrez; Menzo, Emanuele Lo; Szomstein, Samuel; Rosenthal, Raúl J.

doi:10.1016/j.soard.2021.01.040

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…Even if obese patients have normal blood pressure, increased cardiac load may still lead to heart damage. It has been reported that changes in the quality, structure, and function of the heart in obese patients are closely related to their BMI [27]. Studies by Grossman [28] and Zarich [29] have found that obesity can act as an independent risk factor in the development and progression of cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

Sleeve gastrectomy improves cardiac function and glucose-lipid metabolism disorder in obese rats induced by a high-fat and high-sugar diet

Li,

Qiao,

Wang

et al. 2024

Endocr J

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Obesity is affecting global health with multiple complications, including cardiac dysfunction. Currently, it is uncertain whether drug therapy should be applied in the early stages of obesity-induced cardiac dysfunction, with weight reduction as the first choice. Sleeve gastrectomy (SG) has been widely used to treat obesity and its complications, showing promising results. However, it remains unclear whether SG can alleviate obesity-induced cardiac dysfunction. A sudden decline in body weight and food intake was observed in both the obese and obese + SG groups, with a higher rate of increase observed in the Obese group. Elevated levels of plasma glucose, serum insulin, and glycated haemoglobin in obese rats were significantly reduced by SG. Markedly increased levels of alanine transaminase, aspartate transaminase, alkaline phosphatase albumin, total cholesterol, triglycerides, and low-density lipoprotein cholesterol levels, elevated values of heart rate, left ventricular end-systolic pressure, left ventricular end-diastolic pressure, systolic pressure, and end diastolic pressure, and decreased value of stroke volume were observed in obese rats, which were sharply reversed by SG. Furthermore, enhanced pathological changes, including inflammatory cell infiltration and loss of cytoplasm striations, enhanced oil red O staining, increased TUNEL-positive cells, upregulated Bax and cleaved-caspase-3, and downregulated Bcl-2, were observed in obese rats, which were notably alleviated by SG. Lastly, the increased levels of relative proteins observed in obese rats were significantly reduced by SG. In conclusion, SG improved cardiac function and glucose-lipid metabolism disorders in obese rats induced by a high-fat and high-sugar diet.

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Section: Discussionmentioning

confidence: 99%

Sleeve gastrectomy improves cardiac function and glucose-lipid metabolism disorder in obese rats induced by a high-fat and high-sugar diet

Li,

Qiao,

Wang

et al. 2024

Endocr J

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“…There was also lower mortality in patients with preexisting heart failure or preexisting atrial fibrillation. Among those patients with heart failure, bariatric surgeries have been associated with improvements in quality of life, reverse cardiac remodeling [70] and even myocardial remission [71,72], slower progression of heart failure [73], and lower rates of hospitalization due to heart failure [80]. With bariatric surgery, certain patients with left ventricular assist devices have lost enough weight to become candidates for heart transplant, and some even achieved recovery of myocardial function [74 ▪▪ ,75,76].…”

Section: Integrating the Management Of Patient With Obesity Heart Fai...mentioning

confidence: 99%

“…There was also lower mortality in patients with preexisting heart failure or preexisting atrial fibrillation. Among those patients with heart failure, bariatric surgeries have been associated with improvements in quality of life, reverse cardiac remodeling [70] and even myocardial remission [71,72], slower progression of heart failure [73] ]. This highlights the need for a comprehensive multidisciplinary assessment for patient selection and optimization prior to surgery.…”

Section: Bariatric Surgery In Obese Patients With Heart Failurementioning

confidence: 99%

Clinical considerations and pathophysiological associations among obesity, weight loss, heart failure, and hypertension

Barillas-Lara

Faaborg-Andersen

Quintana

et al. 2023

Current Opinion in Cardiology

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Purpose of review To describe the relationship between three pandemics: hypertension, obesity, and heart failure. From pathophysiology to treatment, understanding how these disease entities are linked can lead to breakthroughs in their prevention and treatment. The relevance of this review lies in its discussion of novel pharmacological and surgical treatment strategies for obesity and hypertension, and their role in the prevention and treatment of heart failure. Recent findings Novel medications such as GLP-1 agonists have demonstrated sustained weight loss in patients with obesity, and concurrent improvements in their cardiometabolic profile, and possibly also reductions in hypertension-related comorbidities including heart failure. Surgical therapies including laparoscopic bariatric surgery represent an important treatment strategy in obese patients, and recent studies describe their use even in patients with advanced heart failure, including those with ventricular assist devices. Summary These developments have deep implications on our efforts to understand, mitigate, and ultimately prevent the three pandemics, and offer promising improvements to quality of life, survival, and the cost burden of these diseases.

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The Impact of Bariatric Surgery on Cardiac Structure, and Systolic and Diastolic Function in Patients with Obesity: A Systematic Review and Meta-analysis

Esparham

Shoar²,

Kheradmand

et al. 2022

OBES SURG

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Left ventricular mass index and ventricular contractility improvement in patients with severe obesity following rapid weight loss after bariatric surgery

Cited by 6 publications

References 23 publications

Sleeve gastrectomy improves cardiac function and glucose-lipid metabolism disorder in obese rats induced by a high-fat and high-sugar diet

Sleeve gastrectomy improves cardiac function and glucose-lipid metabolism disorder in obese rats induced by a high-fat and high-sugar diet

Clinical considerations and pathophysiological associations among obesity, weight loss, heart failure, and hypertension

The Impact of Bariatric Surgery on Cardiac Structure, and Systolic and Diastolic Function in Patients with Obesity: A Systematic Review and Meta-analysis

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