Left ventricular mass and ambulatory blood pressure are increased in long-term survivors of childhood cancer after autologous SCT

Abstract

Abbreviations: BMI = body mass index; BSA = body surface area; DOXO = cumulative doxorubicin dose; F = female; HSCT = hematopoietic stem cell transplantation; hs-CRP = high-sensitivity C-reactive protein; M = male; proBNP = N-terminal pro-B-type natriuretic peptide; 24hHR = 24-hr mean heart rate; 24hSYS/DIA% = 24-hr mean systolic or diastolic blood pressure. Results are reported as mean ± s.d.

Skeletal outcome in long-term survivors of childhood high-risk neuroblastoma treated with high-dose therapy and autologous stem cell rescue

“…Three subjects had spinal infiltration at diagnosis (Table 1). Median follow-up time was 20 years (range [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28].…”

“…This is in line with the normal heightadjusted BMDs in the survivors. Another possible explanation for the low fracture rate (14%) in these survivors, who have poor physical performance, 27 is their reduced exercise capacity and thereby less predisposition to fractures than in active, healthy controls. There are no previous studies on fracture risk separately in HR-NBL survivors, but a large Childhood Cancer Survivor Study also found no difference in the fracture rate between long-term cancer survivors and their healthy siblings.…”

Clinical and biological markers of premature aging after autologous SCT in childhood cancer

“…7 Accordingly, we have recently reported signs of premature arterial aging, asymptomatic cardiac dysfunction, increased blood pressure and poor physical performance among long-term survivors of high-risk neuroblastoma (HR NBL) treated with myeloablative regimens. 8,9 The objective of this study was to investigate if long-term survivors of HR NBL are more likely than controls to display frail health and physical health limitations. Since short telomeres are known to be indicators of cellular senescence and to associate with increased oxidative stress and inflammation biomarkers, such as high sensitivity C-reactive protein (hsCRP) and TNF-alpha, we further explored if telomere length, markers of inflammation and variables of cardiovascular function can serve as markers of premature aging in young adult survivors of HR NBL treated in early childhood with intensive induction chemotherapy regimens followed by high dose therapy (HDTx) with hematopoietic stem cell support.…”

Lower quality of life in young men after pediatric kidney transplantation when compared to healthy controls and survivors of childhood leukemia-a cross-sectional study

“…The survival of pediatric patients with end‐stage kidney disease has improved dramatically thanks to successful kidney transplant programs. Despite better life expectancy, it is well recognized that chronic diseases in childhood have a negative impact on QOL in adulthood . There are an increasing number of studies reporting on QOL after pediatric transplantation ; however, in many of these reports, the results are only compared with healthy controls.…”

“…Despite better life expectancy, it is well recognized that chronic diseases in childhood have a negative impact on quality of life (QOL) in adulthood. There is evidence showing that patients with a history of chronic disease and exposure to cytotoxic medication are prone to secondary complications, mainly affecting hormonal function, the cardiovascular system, and neuropsychology . The prevention of secondary complications and avoidance of the adverse effects of immunosuppressive medication have therefore become increasingly important.…”