Left ventricular hypertrophy in pediatric patients on maintenance dialysis: a report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS)

Prospective Study of Modifiable Risk Factors of Arterial Hypertension and Left Ventricular Hypertrophy in Pediatric Patients on Hemodialysis

“… 27 , 28 , 29 A recent NAPRTCS analysis of 518 children followed-up from 2013 to 2020 demonstrated LVH prevalence of 67% at dialysis initiation and 40% to 50% during follow-up. 30 LVH decreases coronary reserve and contributes to a markedly increased risk of cardiovascular mortality, whereas progression of LVH is the strongest predictor of sudden death in young adults on HD. 31 The rate of cardiovascular arrest is 100-fold increased in patients on dialysis as compared to the general population.…”

Rethinking Blood Pressure Management in Children Receiving Maintenance Hemodialysis

“…Similarly, the prevalence of left ventricular hypertrophy (LVH), the most common cardiac abnormality in children on maintenance dialysis, has not changed much from the initial reports in early 2000s, and most recent data demonstrate a frequency of approximately 50%. 1 Controlling hypertension and LVH is recognized as one of the most important strategies to prevent development of cardiovascular disease, most common cause of death in children and young adults with end-stage kidney disease. Although many previous studies have tried to address the causes of poor blood pressure (BP) and LVH control, most of them, including large international registries such as the North American Pediatric Renal Trials and Collaborative Studies or European Renal Association European Dialysis and Transplant Association, provided limited information due to lack of detailed data collection.…”