Left Ventricular Hypertrophy in Hypertensive Adolescents

McNiece, Karen L.; Gupta-Malhotra, Monesha; Samuels, Joshua; Bell, Cynthia; Garcia, Kathleen; Poffenbarger, Timothy; Sorof, Jonathan M.; Portman, Ronald J.

doi:10.1161/hypertensionaha.107.092197

Cited by 204 publications

(62 citation statements)

References 18 publications

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“…28 However, there have been only a limited number of studies of LVMI in children with WCH and the results have been inconsistent. [16][17][18] The current study extends previous experience by comparing LVMI of children with WCH to that of children with normotension and sustained hypertension. Critical to the design is that subjects were closely matched for BMI, which is increased in both WCH and sustained hypertension and is itself an independent determinant of LVMI.…”

Section: Discussionsupporting

confidence: 64%

“…These criteria resulted in a WCH study population with a significantly lower proportion of obesity compared with previous studies. [16][17][18] The disparity in prevalence of LVH between the matched WCH group and the unmatched, more overweight, WCH group emphasizes the importance of obesity as an independent determinant of LVMI and underscores the importance of controlling for BMI in studies of WCH and LVMI. 19,30 The mechanism of increased LVMI in children with WCH cannot be determined from the current study.…”

Section: Discussionmentioning

confidence: 99%

“…15 Few studies have evaluated LVMI in children with WCH. [16][17][18] Furthermore, no previous study of LVMI in children with WCH has matched subjects for body mass index (BMI), a characteristic that is increased in children with WCH and is itself an independent determinant of LVMI. 16,19 The objective of the current study was to determine if children with WCH have evidence of hypertensive target-organ effects by comparing LVMI in children with WCH, normotension, and sustained hypertension, closely matching subjects for BMI, sex, and age.…”

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confidence: 99%

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Left Ventricular Mass Index in Children with White Coat Hypertension

Lande

Meagher

Fisher

et al. 2008

The Journal of Pediatrics

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Objective-To determine if children with white coat hypertension (WCH) have evidence of targetorgan damage by comparing left ventricular mass index (LVMI) of subjects with WCH to that of matched normotensive and hypertensive controls.Study design-Each WCH subject was matched by body mass index (± 10%), age (± 1 year), and sex to a normotensive control and to a hypertensive control. Echocardiograms were reviewed to determine LVMI for each subject. These triple matches were analyzed using repeated measures analysis of variance to detect differences in LVMI between the three groups.Results-Twenty-seven matched triplets were established. The groups were comparable for sex, age, and body mass index (BMI). Mean LVMI was 29.2, 32.3, and 35.1 g/m 2.7 , for normotensives, WCH, and sustained hypertensives, respectively (normotensive vs. WCH, p = 0.028; WCH vs. sustained hypertensive, p = 0.07). Left ventricular hypertrophy was not present in any subject in the normotensive or WCH groups, but was present in 26% of the sustained hypertensive subjects (p < 0.001).Conclusions-After controlling closely for BMI, children with WCH had a LVMI which was intermediate between that of normotensives and sustained hypertensives, suggesting that WCH may be associated with hypertensive end-organ effects.White coat hypertension (WCH) occurs when blood pressure is elevated in the medical office but is normal outside the office setting. In adults, there is concern that WCH may be an independent risk factor for cardiovascular disease or that it may represent a prehypertensive state, with increased risk of progression to sustained hypertension. 1 Numerous adult studies have evaluated left ventricular mass index (LVMI) in subjects with WCH. Many, but not all, Corresponding Author: Marc B. Lande, MD, 601 Elmwood Ave, Box 777, Rochester, NY 14642, Phone: 585-275-9784, Fax: 585-756-8054, Email: marc_lande@urmc.rochester.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. The objective of the current study was to determine if children with WCH have evidence of hypertensive target-organ effects by comparing LVMI in children with WCH, normotension, and sustained hypertension, closely matching subjects for BMI, sex, and age. NIH Public Access MethodsThe study was performed at the University of Rochester Medical Center in Rochester, NY. At this center, ABPM has been used in the evaluation of pediatric primary hypertension since October 2002. The clinical purpose of ABPM has been primarily to differentiate between sustained hypertension and white coat hypertension. It has been our practice to obtain ech...

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Left Ventricular Mass Index in Children with White Coat Hypertension

Lande

Meagher

Fisher

et al. 2008

The Journal of Pediatrics

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“…1 -4 High blood pressure (BP) in childhood is associated with target organ damage, notably left ventricular hypertrophy, which is an independent risk factor for cardiovascular disease among adults. 5,6 Children and adolescents with high BP may be at risk for hypertensive disease in adulthood, 7,8 contributing to adverse cardiovascular outcomes. Appropriate changes in lifestyle patterns would be able to decrease the later incidence and severity of cardiovascular diseases.…”

Section: Introductionmentioning

confidence: 99%

Association Between Sleep Duration and Hypertension Among Chinese Children and Adolescents

Guo

Zheng

Yang

et al. 2011

Clinical Cardiology

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Background: Short sleep duration was reported to be associated with an increased risk of hypertension among adults. The present study aimed to investigate this association in children and adolescents. Hypothesis: Short sleep duration is related to higher risk of hypertension among children and adolescents. Methods: We conducted a cross-sectional study of 4902 children and adolescents age 5 to 18 years. Blood pressure (BP) was measured at the research center and classified using the population-based percentiles. Sleep duration and related information were determined through questionnaires. Results: The prevalence of hypertension and prehypertension were 20.3% and 15%, respectively. The median sleep duration was 8.77 ± 1.07 hours (mean ± standard deviation). A short sleep duration (<9 hours) was associated with a higher risk of hypertension when compared with the group sleeping longer (9

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“…Daniels i sur. su u 8-41 % djece s AH našli LVMI viši od 95. percentile, a 10-15,5 % od njih je imalo LVMI > 51 g/m 2,7 . U studiji Stabouli i sur.…”

Section: Hipertrofija Lijeve Klijetke I Arterijska Hipertenzijaunclassified

Left ventricular hypertrophy in children and adolescents with arterial hypertension

Herceg-Čavrak

2017

Cardiologia Croatica

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Hipertrofija lijeve klijetke u djece i adolescenata s arterijskom hipertenzijomLeft ventricular hypertrophy in children and adolescents with arterial hypertension SAŽETAK: Arterijska hipertenzija u djece i adolescenata postala je sve važniji javnozdravstveni problem jer je njezina prevalencija u porastu. Longitudinalne su studije pokazale da će djeca, a osobito adolescenti s arterijskom hipertenzijom vjerojatno postati hipertenzivni odrasli s rizicima od kardiovaskularnih bolesti. Iako su kardiovaskularne bolesti vrlo rijetke u djetinjstvu, povišen arterijski tlak može već u dječjoj i adolescentnoj dobi uzrokovati promjene na ciljnim organima. Hipertrofija lijeve klijetke najčešće je traženo oštećenje ciljnih organa uz pedijatrijsku hipertenziju. U više različitih studija nađena je pozitivna korelacija između visine arterijskoga tlaka i indeksa mase lijeve klijetke, a prevalencija hipertrofije lijeve klijetke u djece s hipertenzijom je 8-41 %. Uočena je povezanost arterijske hipertenzije u djece i adolescenata i krutosti arterija, debljine intime-medije, kao i drugih kardiovaskularnih rizika. SUMMARY:The growing prevalence of arterial hypertension in children and adolescents is becoming an ever-greater public health problem. Longitudinal studies show that children and in particular adolescents with arterial hypertension are highly likely to become hypertensive adults, including the risk of cardiovascular disease. Although cardiovascular diseases are very rare in childhood, elevated arterial pressure can cause lesions of target organs already in childhood and adolescence. Left ventricular hypertrophy is a target organ lesion that is most frequently searched for in pediatric hypertension. Several studies have reported positive correlation between arterial pressure and left ventricular mass index, while the prevalence of left ventricular hypertrophy in children with hypertension was 8-41%. An association was found of arterial hypertension in children and adolescents with arterial stiffness, intima-media thickness, and other cardiovascular risks.KLJUČNE RIJEČI: arterijska hipertenzija, djeca, adolescenti, hipertrofija lijeve klijetke. UvodArterijska hipertenzija (AH) u djece i adolescenata postala je sve važniji javnozdravstveni problem jer je njezina prevalencija u porastu i u djece od 8 do 18 godina iznosi 2-3,6 %, a u adolescenata od 18 godina oko 10 % 1 . Primarna AH danas je jedna od najčešćih kroničnih bolesti u adolescenciji. Epidemija pretilosti koja se pojavila zadnjih godina znatno je pridonijela porastu prevalencije AH koja u prekomjerno teške i pretile djece iznosi čak 27-47 % 2 . Longitudinalne su studije pokazale da će djeca, a osobito adolescenti, s AH vjerojatno postati hipertenzivni odrasli s rizicima od kardiovaskularnih bolesti (KVB) 3 .

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Left Ventricular Hypertrophy in Hypertensive Adolescents

Cited by 204 publications

References 18 publications

Left Ventricular Mass Index in Children with White Coat Hypertension

Left Ventricular Mass Index in Children with White Coat Hypertension

Association Between Sleep Duration and Hypertension Among Chinese Children and Adolescents

Left ventricular hypertrophy in children and adolescents with arterial hypertension

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