Left ventricular hypertrophy detected by echocardiography in HIV-infected patients

Pombo, Marta; Olalla, Julián; Arco, Alfonso del; Torre, Javier de la; Urdiales, D.; Aguilar, Ana; Prada, José Luis; García‐Alegría, Javier; Ruiz-Mateas, Francisco

doi:10.1016/j.ejim.2013.04.007

Cited by 10 publications

(12 citation statements)

References 33 publications

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“…The results of a Price study, 2017 at the Cipto Mangukusumo Hospital in Jakarta, Indonesia, concluded that HIV patients taking antiretroviral therapy were at risk of experiencing heart structure damage after a year of use. Similar to the study conducted by Pombo et al (2013) which found that after a year of ART use, HIV patients experienced left ventricular hypertrophy (LVH) (16). Research conducted in Germany also concluded the same results where HIV patients who take antiretroviral therapy are at high risk for changes in the left ventricular wall (18).…”

Section: Discussionsupporting

confidence: 57%

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Risk of cardiovascular disorders in HIV patients in Indonesia: Literature Review

Fahmi¹

2019

IJNHS

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Abstract HIV is a major health problem in the world. HIV infection has the effect of reducing immunity status and increasing the risk of cardiovascular disease. Antiretroviral (ART) use as a therapy for HIV also increases the risk of heart disease. Objective: This literature review aims to identify the risk of cardiovascular disorders in HIV patients in Indonesia. Method: literature review of articles published January 2009 to September 2018 using search keywords namely 'Anti-retroviral therapy', 'Cardiovascular disease', 'Corronary artery disease', and 'HIV'. Results: There were 21 journal articles that were relevant to the design and purpose of paper and 3 articles that discussed the risk of heart disease in HIV patients in Indonesia. The results of the literature review showed that HIV patients in Indonesia are at risk of developing cardiovascular disorders which are exacerbated by the use of ART and smoking behavior. The risk of cardiovascular disease includes structural abnormalities and coronary heart disease. Conclusion: HIV patients have a high risk of developing cardiovascular disease. This is a challenge for health workers, the government and researchers, to develop appropriate strategies and methods in reducing the risk of cardiovascular disorders especially in low-middle income country countries such as Indonesia. Keyword: Anti-retroviral therapy, cardiovascular disease, HIV, AIDS, HIV in Indonesia

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Section: Discussionsupporting

confidence: 57%

“…Left ventricular hypertrophy (LVH) is a predictor of all deaths in the general population 16 . Also, LVH is a predictor of the incidence of cardiovascular disease, where this risk is increased in people infected with HIV (17).…”

Section: Discussionmentioning

confidence: 99%

Risk of cardiovascular disorders in HIV patients in Indonesia: Literature Review

Fahmi¹

2019

IJNHS

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“…Left ventricular hypertrophy (LVH) has been previously reported to be associated with diastolic LV dysfunction in HIV patients . Age, presence of hypertension, global cardiovascular disease risk, and the use of nevirapine have all been associated with LVH in HIV patients.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Human Immunodeficiency Virus Infection‐Related Left Ventricular Systolic Dysfunction by Tissue Doppler Strain Echocardiography

et al. 2014

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“…HIV-related factors were categorized as follows: CD4 + cell count (>200 cells/μl and ≤200 cells/μl), HIV viral load (≤400 copies/ml and >400 copies/ml), age at ART initiation (0–5, 6–10 and 11–16 years), duration on ART (≤2 years and >2 years) and age was categorized as 6–10 years and 11–16 years. Antiretroviral drugs, cardiac signs and symptoms, hypertension and chronic lung disease were dichotomized into ‘yes’ and ‘no.’ Zidovudine and nevirapine were selected because of the evidence that zidovudine is associated with development of cardiomyopathy in children and nevirapine is associated with LVH in adults [ 28 , 29 ]. Clinical factors evaluated include cardiac signs and symptoms, hypertension and chronic lung disease.…”

Section: Methodsmentioning

confidence: 99%

High prevalence of echocardiographic abnormalities in older HIV-infected children taking antiretroviral therapy

Majonga

Rehman

Simms

et al. 2018

Aids

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Background:Antiretroviral therapy (ART) has decreased mortality so that increasing numbers of children with HIV are reaching adolescence. However, longstanding HIV infection and/or its treatment in children is associated with noninfectious complications including cardiac disease. We investigated the prevalence, spectrum and risk factors for echocardiographic abnormalities among children established on ART.Methods:HIV-infected children aged 6–16 years, on ART at least 6 months were enrolled into a cross-sectional study from a public-sector paediatric HIV clinic in Harare, Zimbabwe. A standardized examination including transthoracic echocardiography was performed. Local echocardiographic reference ranges were used to define cardiac abnormalities. Logistic regression was used to examine the association between cardiac abnormalities and risk factors.Results:Of the 201participants recruited, 92 (46%) were girls and median age was 11 (IQR 9–12) years; CD4+ cell count was 727 cells/μl (IQR 473–935) and 154 (78%) had viral load less than 400 copies/ml. Echocardiographic abnormalities were found in 83 (42%); left ventricular (LV) diastolic dysfunction was the most common abnormality 45 (23%) and LV hypertrophy in 22 (11%). LV and left atrial dilatation were found in 9 (5%) and 16 (8%), respectively. Right ventricular dilatation and systolic dysfunction were found in 13 (7%) and 4 (2%), respectively, of whom 60% had concurrent left heart abnormalities. Current use of nevirapine was associated with LVH [aOR 3.14 (1.13–8.72; P = 0.03)] and hypertension was associated with LV diastolic dysfunction [aOR 3.12 (1.48–6.57; P < 0.01)].Conclusion:HIV-infected children established on ART have a high burden of echocardiographic abnormalities. Right heart disease was predominantly associated with left heart abnormalities and may be part of a global cardiomyopathic process. Further studies are needed to investigate the natural history, aetiology, and pathogenesis of these abnormalities, so that appropriate monitoring and treatment strategies can be developed.

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Left ventricular hypertrophy detected by echocardiography in HIV-infected patients

Cited by 10 publications

References 33 publications

Risk of cardiovascular disorders in HIV patients in Indonesia: Literature Review

Risk of cardiovascular disorders in HIV patients in Indonesia: Literature Review

Evaluation of Human Immunodeficiency Virus Infection‐Related Left Ventricular Systolic Dysfunction by Tissue Doppler Strain Echocardiography

High prevalence of echocardiographic abnormalities in older HIV-infected children taking antiretroviral therapy

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