Left ventricular hypertrophy and blood pressure as predictors of cognitive decline in old age

Kähönen-Väre, Mervi H; Brunni-Hakala, Suvi; Lindroos, Magnus; Pitkälä, Kaisu; Strandberg, Timo; Tilvis, Reijo S.

doi:10.1007/bf03324544

Cited by 63 publications

(52 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although this observation is consistent with some prior work,9, 10 the remaining null cognitive results contrast with literature reporting cognitive associations with LVH8 or increased LV mass index3, 28 in aging cohorts that include dementia cases. Although increased LV mass index is an early marker of pathologic LV remodeling, it may not strongly correspond with subtle cognitive changes in cognitively normal individuals or elders with only mild prodromal symptoms of dementia, such as those participants studied here.…”

Section: Discussionsupporting

confidence: 89%

“…Although increased LV mass index is an early marker of pathologic LV remodeling, it may not strongly correspond with subtle cognitive changes in cognitively normal individuals or elders with only mild prodromal symptoms of dementia, such as those participants studied here. Furthermore, prior work has shown that the association between increased LV mass index and cognition is attenuated when other cardiovascular risk factors are adjusted for,3, 8, 9, 10 as was done here with the inclusion of a vascular risk score.…”

Section: Discussionmentioning

confidence: 94%

“…Left ventricular (LV) hypertrophy (LVH), a pathologic increase in LV mass, is associated with cerebrovascular disease,1 white matter hyperintensities,2 and cognitive decline3 in aging individuals, particularly elders with hypertension 4, 5. Increased LV mass index (LV mass/body surface area) is an imaging marker that precedes LVH6 and reflects subclinical pathologic remodeling of the ventricular wall.…”

Section: Introductionmentioning

confidence: 99%

“…Given prior research linking overt LVH to cognitive impairment3 and white matter lesions,2 we hypothesized that higher LV mass index would correlate with compromised white matter microstructure on DTI and worse neuropsychological performance (especially memory) 10. Secondarily, we tested whether associations differed by cognitive diagnosis.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Increased Left Ventricular Mass Index Is Associated With Compromised White Matter Microstructure Among Older Adults

Moore

Liu

Pechman

et al. 2018

JAHA

View full text Add to dashboard Cite

BackgroundLeft ventricular (LV) hypertrophy is associated with cerebrovascular disease and cognitive decline. Increased LV mass index is a subclinical imaging marker that precedes overt LV hypertrophy. This study relates LV mass index to white matter microstructure and cognition among older adults with normal cognition and mild cognitive impairment.Methods and ResultsVanderbilt Memory & Aging Project participants free of clinical stroke, dementia, and heart failure (n=318, 73±7 years, 58% male, 39% mild cognitive impairment) underwent brain magnetic resonance imaging, cardiac magnetic resonance, and neuropsychological assessment. Voxelwise analyses related LV mass index (g/m2) to diffusion tensor imaging metrics. Models adjusted for age, sex, education, race/ethnicity, Framingham Stroke Risk Profile, cognitive diagnosis, and apolipoprotein E–ε4 status. Secondary analyses included a LV mass index×diagnosis interaction term with follow‐up models stratified by diagnosis. With identical covariates, linear regression models related LV mass index to neuropsychological performances. Increased LV mass index related to altered white matter microstructure (P<0.05). In models stratified by diagnosis, associations between LV mass index and diffusion tensor imaging were present among mild cognitive impairment participants only (P<0.05). LV mass index was related only to worse visuospatial memory performance (β=−0.003, P=0.036), an observation that would not withstand correction for multiple testing.ConclusionsIn the absence of prevalent heart failure and clinical stroke, increased LV mass index corresponds to altered white matter microstructure, particularly among older adults with clinical symptoms of prodromal dementia. Findings highlight the potential link between subclinical LV remodeling and cerebral white matter microstructure vulnerability.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Increased Left Ventricular Mass Index Is Associated With Compromised White Matter Microstructure Among Older Adults

Moore

Liu

Pechman

et al. 2018

JAHA

View full text Add to dashboard Cite

show abstract

“…These imaging markers of cSVD are strongly associated with cognitive function 3, 4, 5, 6. Other types of hypertensive organ damage, such as cardiac and renal damages, have also been linked to lower cognitive function or increased risk of cognitive impairment 7, 8, 9, 10, 11…”

Section: Introductionmentioning

confidence: 99%

Hypertensive organ damage predicts future cognitive performance: A 9‐year follow‐up study in patients with hypertension

Uiterwijk

Staals

Huijts

et al. 2018

J of Clinical Hypertension

View full text Add to dashboard Cite

Hypertension is associated with cognitive deficits, probably caused by cerebral small vessel disease. The authors examined whether additional presence of cardiac and renal organ damages, and their combined presence, are associated with future cognitive performance. In 78 patients with essential hypertension (mean age 51.2 ± 12.0 years), brain damage was determined by MRI features, cardiac damage by left ventricular mass index (LVMI), and renal damage by estimated glomerular filtration rate (eGFR) and albuminuria. At 9‐year follow‐up, neuropsychological assessment was performed. LVMI was associated with future lower cognition (P = 0.032), independent of age, sex, premorbid cognition, and brain damage, but eGFR and albuminuria were not. The presence of 2 or 3 types of organ damage compared to none was associated with future lower cognition. Increasing number of hypertensive organ damages, and cardiac damage independently of brain damage, might indicate a more severe hypertensive disease burden and could help to identify patients at risk of cognitive problems.

show abstract

Current awareness in geriatric psychiatry

2004

Int J Geriat Psychiatry

View full text Add to dashboard Cite

In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of geriatric psychiatry. Each bibliography is divided into 9 sections: 1 Books, Reviews & Symposia; 2 General; 3 Assessment; 4 Epidemiology; 5 Therapy; 6 Care; 7 Dementia; 8 Depression; 9 Psychology. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted

show abstract

Left ventricular hypertrophy and blood pressure as predictors of cognitive decline in old age

Abstract: Results indicate that, the closer cognitive decline, the lower the BP, and suggest that, although LVH is a risk factor of cognitive decline, it loses its predictive value in old age.

Cited by 63 publications

References 34 publications

Increased Left Ventricular Mass Index Is Associated With Compromised White Matter Microstructure Among Older Adults

Increased Left Ventricular Mass Index Is Associated With Compromised White Matter Microstructure Among Older Adults

Hypertensive organ damage predicts future cognitive performance: A 9‐year follow‐up study in patients with hypertension

Current awareness in geriatric psychiatry

Contact Info

Product

Resources

About