Left ventricular geometry and function in early repolarization: results from the population-based Gutenberg Health Study

Trenkwalder, Teresa; Rübsamen, Nicole; Schmitt, Volker H.; Arnold, Natalie; Kaess, Bernhard M.; Sinning, Christoph; Zeller, Tanja; Beutel, Manfred E.; Schmidtmann, Irene; Nickels, Stefan; Pfeiffer, Norbert; Leuschner, Anja; Münzel, Thomas; Lackner, Karl J.; Hengstenberg, Christian; Blankenberg, Stefan; Wild, Philipp S.; Reinhard, Wibke; Schnabel, Renate B.

doi:10.1007/s00392-019-01445-7

Cited by 12 publications

(26 citation statements)

References 36 publications

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“… 1,4,5 The pathophysiological mechanism of arrhythmic events in ERP was primarily explained by electrophysiological alterations 6–8 . Besides, recent studies have demonstrated a significant association between ERP and myocardial structural changes including increased left ventricular (LV) mass and change in LV geometry as well as functional LV alterations such as impaired LV filling 9,10 . Although the relationship between ERP and myocardial structural changes has been clearly demonstrated, it is not exact whether ERP itself leads to myocardial dysfunction.…”

Section: Introductionmentioning

confidence: 99%

The diagnostic value of 2D‐speckle tracking echocardiography for identifying subclinical ventricular dysfunction in subjects with early repolarization pattern

2021

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Introduction Early repolarization pattern (ERP) can exist a silent substrate for arrhytmic events in accordance with the previous studies which have shown there has been evidence of morphological changes in left ventricle (LV) in ERP subjects. Despite structural changes in ERP subjects, it has not exactly known whether a change in LV functional parameters occur in ERP. The aim of our study was to investigate LV functional parameters in ERP athletes evaluated by 2D‐ speckle tracking echocardiography (2D‐STE). Method In this study, athletes with ERP (n = 50) and athletes without ERP (n = 50) were recruited between April 2018 and September 2018. For each case, 2D‐ TTE and 2D‐ STE evaluation were performed by the same cardiologist. Results Left ventricle mean global longitudinal strain (GLS) (P < .001) and GLS at all apical chamber views (P < .001), longitudinal peak systolic strain rate (SRS) at A3C (P: .011), early diastolic strain rate (SRE) at A3C (P < .001) and late diastolic strain rate (SRA) at A3C (P: .034) in the ERP athletes were significantly lower than those in the athletes without ERP. LV basal segment circumferential SRS (P: .002) and SRE (P: .006) were significantly lower in ERP athletes compared to athletes without ERP. LV mechanical dispersion was significantly higher in ERP athletes compared to athletes without ERP (P < .001). Conclusion Our study suggests ERP can be more associated with impaired LV longitudinal function than circumferential function. In addition, both LV inferolateral region and basal segment can be more affected functionally in ERP athletes.

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Section: Introductionmentioning

confidence: 99%

The diagnostic value of 2D‐speckle tracking echocardiography for identifying subclinical ventricular dysfunction in subjects with early repolarization pattern

2021

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“…The early repolarization pattern (ERP) is a common ECG finding characterized by an elevation at the QRS-ST junction (J point) of at least 0.1 mV in 2 adjacent ECG leads. The prevalence of ERP in the general population ranges from 2% to 13% and is more common in young athletic men (1)(2)(3)(4)(5). The classical notion of ERP being a benign ECG phenotype was challenged in 2008 by a landmark study by Haïssaguerre and colleagues showing an association of ERP with increased risk of ventricular fibrillation and sudden cardiac death (6): the early repolarization syndrome (ERS) (7).…”

Section: Introductionmentioning

confidence: 99%

KCND3 potassium channel gene variant confers susceptibility to electrocardiographic early repolarization pattern

Teumer¹,

Trenkwalder²,

Kessler³

et al. 2019

JCI Insight

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“…Unfortunately, these arrhythmic events can be seen in the young people without cardiac disease such as ischemic heart diseases, cardiomyopathies 18 . However, Trenkwalder et al and McNamara et al showed that the morphological changes of LV began to be seen in ERP subjects 9,10 . In these subjects, ventricular dysfunction can not be determined with the use of conventional echocardiographic modalities 18,19 .…”

Section: Discussionmentioning

confidence: 99%

“…The pathophysiological mechanism of arrhythmic events in ERP was primarily explained by electrophysiological alterations [6][7][8] . Besides, recent studies have demonstrated a significant association between ERP and myocardial structural changes including increased left ventricular (LV) mass and change in LV geometry as well as functional LV alterations such as impaired LV filling 9,10 . Although the relationship between ERP and myocardial structural changes clearly has been shown, it is not exact whether ERP own leads to myocardial dysfunction.…”

Section: Introductionmentioning

confidence: 99%

The Diagnostic Value of 2D- Speckle Tracking Echocardiography for Identifying Subclinical Ventricular Dysfunction in Subjects with Early Repolarization Pattern

Colluoglu

Özer

Cakan

2021

Preprint

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Introduction: Early repolarization pattern (ERP) has been known a benign electrocardiographic variant for decades. However, it can exist a silent substrate for arrhytmic events in accordance with the previous studies which have shown that there has been evidence of morphological changes in left ventricle (LV) in subjects with ERP. Despite structural changes in ERP subjects, it has not exactly known that whether a change in functional parameters of LV occur in these population. The aim of our study was to investigate LV functional parameters in subjects with ERP by the use of 2D- speckle tracking echocardiography (2D-STE). Method: In this study, subjects with ERP (n= 50) and subjects without ERP (n= 50) were recruited between 01.04.2018 and 01.09.2018. For each case, 2D- STE evaluation was performed by the same cardiologist. Results: Mean LV global longitudinal strain (GLS) and GLS in all apical chamber views, longitudinal peak systolic strain rate (SRS) at A3C, early diastolic strain rate (SRE) at A3C and late diastolic strain rate (SRA) at A3C in the ERP subjects were significantly lower than those in the subjects without ERP. Furthermore, LV basal segment circumferential SRS and SRE were significantly lower in ERP subjects compared to subjects without ERP. Conclusion: Our study suggests that ERP can be more associated with impaired LV longitudinal function than LV circumferential function. In addition, both LV inferolateral region and LV basal segment can be more affected functionally in ERP subjects.

show abstract

Left ventricular geometry and function in early repolarization: results from the population-based Gutenberg Health Study

Cited by 12 publications

References 36 publications

The diagnostic value of 2D‐speckle tracking echocardiography for identifying subclinical ventricular dysfunction in subjects with early repolarization pattern

The diagnostic value of 2D‐speckle tracking echocardiography for identifying subclinical ventricular dysfunction in subjects with early repolarization pattern

KCND3 potassium channel gene variant confers susceptibility to electrocardiographic early repolarization pattern

The Diagnostic Value of 2D- Speckle Tracking Echocardiography for Identifying Subclinical Ventricular Dysfunction in Subjects with Early Repolarization Pattern

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