Left Ventricular Energy Loss Assessed by Vector Flow Mapping in Patients with Prediabetes and Type 2 Diabetes Mellitus

Wang, Yi; Ma, Rongchuan; Ding, Geqi; Hou, Dailun; Li, Zhaohuan; Yin, Long; Zhang, Mei

doi:10.1016/j.ultrasmedbio.2016.03.008

Cited by 26 publications

(46 citation statements)

References 30 publications

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“…reported that EL could be used to evaluate the ventricular workload of uremic hearts of the patients with end‐stage renal disease. In the research of prediabetes and type 2 diabetes mellitus (DM), it is demonstrated that EL may become a more sensitive parameter than conventional echocardiographic index to detect the cardiac dysfunction in pre‐DM patients. In the study of aortic regurgitation, it considered that EL may be useful to determine the severity of disease from the aspect of cardiac load.…”

Section: Discussionmentioning

confidence: 99%

Characterization of left ventricle energy loss in healthy adults using vector flow mapping: Preliminary results

Sun

Zhu

et al. 2017

Echocardiography

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Energy loss in LV changes regularly during the cardiac cycle. The average systolic EL has a high positive correlation with AOVTI, whereas the average diastolic EL has with E-wave peak velocity. Women have higher average EL than men in both systole and diastole. By recognizing the EL characterization of healthy adults, the variation in EL may reflect cardiac dysfunction. These were preliminary results, and thus, the clinical implications of EL warrant further investigation.

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Section: Discussionmentioning

confidence: 99%

Characterization of left ventricle energy loss in healthy adults using vector flow mapping: Preliminary results

Sun

Zhu

et al. 2017

Echocardiography

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“…Recently, energy loss (EL) and vortex circulation are two novel desirable parameters for the quantification of VFM. EL, a new blood flow dynamic parameter for assessing cardiac function, is caused by viscosity‐driven friction among the vortex ring, the lateral LV wall, and blood flow, and can reflect the efficiency of the intra‐ventricular flow . Vortex circulation, which is representative of the strength of a vortex, is equivalent to the integral of normal component of “vorticity” on arbitrary plane enclosed by closed curve.…”

Section: Introductionmentioning

confidence: 85%

“…The quantitative assessment of intra‐ventricular blood flow dynamics has been considered as a potential novel indicator for left ventricular (LV) pump efficiency . At present, there are several reliable methods of visualizing intracardiac flows.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of left ventricular diastolic function based on flow energetic parameters in chronic kidney disease with diastolic dysfunction

Wang

Chen

et al. 2019

Echocardiography

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Background Intra‐ventricular blood flow dynamics is considered as an important component of left ventricular (LV) function assessment. The purpose of this study was to evaluate the LV diastolic function in chronic kidney disease (CKD) with different degrees of LV diastolic dysfunction (LVDD) by using flow energetic parameters. Methods In this study, a total of 96 cases were recruited, including 58 CKD patients and 38 healthy controls. CKD patients were divided into 2 groups according to LVDD severity, named as DD1 and DD2. Vector flow‐mapping (VFM) analysis was executed to calculate left ventricle average energy loss (EL) during early filling phase (E‐EL_ave), atrial filling phase (A‐EL_ave), diastole phase (D‐EL_ave), and ejection phase (S‐EL_ave). Moreover, the average vortex circulation during early filling phase (E‐cir_ave) and atrial filling phase (A‐cir_ave) was also assessed in the apical three‐chamber view. The rate of average EL during early filling and atrial filling was expressed as E/A‐EL. Result Compared to the control group, A‐EL_ave, S‐EL_ave, and A‐cir_ave in the DD1 group were higher (P < 0.05), and all parameters were obviously higher in the DD2 group (P < 0.05). In the control group and the DD2 subgroup, the E‐EL_ave value was significantly higher than A‐EL_ave value, which was opposite to the DD1 group. As diastolic dysfunction worsened, E‐EL_ave and D‐EL_ave risen gradually (P < 0.05), and A‐EL_ave and S‐EL_ave were slightly elevated with no significance. There were significant correlations between LV diastolic function and flow energetic parameters. Stepwise multiple regression analysis revealed that various LV function parameters could be regarded as independent predictors of average diastolic EL (all P < 0.01). Conclusions For CKD patient with LVDD and LVEF > 50%, effective LV filling and systolic ejection with optimized energy consumption have been impaired. As a new flow‐derived index, EL can quantitatively evaluate LV diastolic function in terms of blood fluid dynamics in CKD with various LVDD.

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“…[2] Intraventricular vortex formed by the morphology and function of the cardiovascular system can reveal the global diastolic function of LV and the exceptional adaptability of cardiovascular system for maintaining the blood circulation relatively constant under a wide range of workload. [3] …”

Section: Introductionmentioning

confidence: 99%

Relationship between the abnormal diastolic vortex structure and impaired left ventricle filling in patients with hyperthyroidism

et al. 2017

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Intraventricular hydrodynamics plays an important role in evaluating cardiac function. Relationship between diastolic vortex and left ventricular (LV) filling is still rarely elucidated. The aim of this study was to evaluate the evolution of vortex during diastole in hyperthyroidism (HT) and explore the alteration of hydromechanics characteristics with sensitive indexes.Forty-three patients diagnosed with HT were classified into 2 groups according to whether myocardial damage existed: simple hyperthyroid group (HT1, n = 21) and thyrotoxic cardiomyopathy (HT2, n = 22). Twenty-seven age- and gender-matched healthy volunteers were enrolled as the control group. Offline vector flow mapping (VFM model) was used to analyze the LV diastolic blood flow patterns and fluid dynamics. Hemodynamic parameters, vortex area (A), circulation (C), and intraventricular pressure gradient (ΔP), in different diastolic phases (early, mid, and late) were calculated and analyzed.HT2, with a lower E/A ratio and left ventricular ejection fraction (LVEF), had a larger left atrium diameter (LAD) compared with those of the control group and HT1 (P < .05). Compared with the control group, the vortex size and strength, intraventricular pressure gradient during early and mid-diastole were higher in HT1 and lower in HT2 (P < .05). And in late diastole, the vortex size and strength, intraventricular pressure gradient of HT2 became higher than those of the control group (P < .05). Good correlation could be found between CE and E/A (P < .05), CM and ΔPM (P < .01), CL and FT3 (P < .05).VFM is proven practical for detecting the relationship between the changes of left ventricular diastolic vortex and the abnormal left ventricular filling.

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Left Ventricular Energy Loss Assessed by Vector Flow Mapping in Patients with Prediabetes and Type 2 Diabetes Mellitus

Cited by 26 publications

References 30 publications

Characterization of left ventricle energy loss in healthy adults using vector flow mapping: Preliminary results

Characterization of left ventricle energy loss in healthy adults using vector flow mapping: Preliminary results

Evaluation of left ventricular diastolic function based on flow energetic parameters in chronic kidney disease with diastolic dysfunction

Relationship between the abnormal diastolic vortex structure and impaired left ventricle filling in patients with hyperthyroidism

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