Left ventricular ejection performance, wall stress, and contractile state in aortic regurgitation before and after aortic valve replacement.

Taniguchi, Koichi; Nakano, Susumu; Kawashima, Yasunaru; Sakai, Kanae; Kawamoto, Tomoaki; Sakaki, S; Kobayashi, Junjiro; Morimoto, S; Matsuda, Hikaru

doi:10.1161/01.cir.82.3.798

Cited by 77 publications

(29 citation statements)

References 43 publications

(6 reference statements)

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“…2,[12][13][14] But as shown in Fig. 4 in the present study, there were a number of cases with pre-operative LVESD > 55 mm that decreased in LV size after the operation.…”

Section: Discussionsupporting

confidence: 38%

Study of Left Ventricular Diastolic Diameter–peak Stress Relationship Before and After Valve Replacement Operation for Patients With Chronic Aortic Regurgitation

Wang

2008

Biomed. Eng. Appl. Basis Commun.

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Background: Patients with chronic aortic regurgitation (AR) usually have dilated left ventricle due to volume overload. Some of them will reduce in size after elimination of regurgitation, but others not. The present study evaluated the hypothesis that left ventricle end-diastolic diameter (LVEDD), left ventricle end-systolic diameter (LVESD) are related to left ventricle's peak stress (σ) both before and after operation.Methods: Sixty-eight patients with chronic aortic regurgitation receiving valve replacement were included in the study. LVEDD, LVESD, and σ were determined by echocardiography and cuff sphygmomanometer measurement before and beyond 6 months after operation.Results: The results showed that LVEDD, LVESD, and σ were decreased after the operation. In addition, σ and LVEDD had good linear correlation (for pre-operative data, σ = −3.02 + 0.286 * LVEDD, R = 0.556, P < 0.001; for post-operative data, σ = −11.4 + 0.474 * LVEDD, R = 0.736, P < 0.001).Conclusion: LVEDD and σ had a linear relationship before and after valve replacement operation for AR patients. The higher slope in linear regression equation for post-operative σ-LVEDD relationship than that for pre-operative data may indicate improved myocardial contractile efficiency after the operation.

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“…2,[12][13][14] But as shown in Fig. 4 in the present study, there were a number of cases with pre-operative LVESD > 55 mm that decreased in LV size after the operation.…”

Section: Discussionsupporting

confidence: 38%

Study of Left Ventricular Diastolic Diameter–peak Stress Relationship Before and After Valve Replacement Operation for Patients With Chronic Aortic Regurgitation

Wang

2008

Biomed. Eng. Appl. Basis Commun.

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“…Both end-diastolic and end-systolic sphericity indices significantly decreased after the operation. The ratio of global ESS to LVESVI (ESS/ ESVI), which was a relatively load-independent index for estimating myocardial contractility, 14,15 significantly improved from 1.5Ϯ0.5 to 1.7Ϯ0.5 (Pϭ0.008), with a mean increase of 17% ( Figure 2). …”

Section: Changes In LV Ejection Performance and Wall Stress Before Anmentioning

confidence: 99%

Mechanism of Beneficial Effects of Restrictive Mitral Annuloplasty in Patients With Dilated Cardiomyopathy and Functional Mitral Regurgitation

et al. 2010

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Background-Restrictive mitral annuloplasty (RMA) often leads to reverse left ventricular (LV) remodeling in patients with advanced cardiomyopathy and functional mitral regurgitation. However, the mechanism responsible for its favorable effects on LV ejection performance has been poorly understood. We evaluated systolic wall stress using cineangiographic multidetector computed tomography (MDCT) and our developed software system to assess stress-shortening relations before and after RMA. Methods and Results-Twenty-four patients with dilated cardiomyopathy underwent 64-row MDCT before and 2 months after RMA. All patients underwent stringent downsizing annuloplasty with a semirigid complete ring. Reconstructed images were used to calculate LV end-diastolic index (EDVI) and end-systolic volume index (ESVI), LV ejection fraction, and regional and global end-systolic wall stress (ESS). After RMA, LVEDVI and LVESVI decreased from 151Ϯ52 to 131Ϯ53 mL/m 2 (Pϭ0.0001) and from 114Ϯ48 to 92Ϯ50 mL/m 2 (Pϭ0.0001), respectively. Global ESS decreased from 157Ϯ43 to 139Ϯ50 kdyne/cm 2 (Pϭ0.01), and LV ejection fraction improved from 27Ϯ8.0 to 33Ϯ13% (Pϭ0.0007). There were significant correlations between change in LVEDVI and LVESVI (rϭ0.88, PϽ0.0001) and change in LVESVI and global ESS (rϭ0.68, Pϭ0.0002). Moreover, the magnitude of increase in LV ejection fraction significantly correlated with the degree of reduction in global ESS (rϭϪ0.61, Pϭ0.002). Patients without significant reverse LV remodeling had significantly higher preoperative and postoperative global ESS than those with it. Conclusions-Our study suggests that decrease in afterload after reduction in volume overload was responsible for postoperative reverse LV remodeling process after RMA.

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“…Our pre-and postoperative cardiac catheterization and quantitative cineventriculography techniques have been described [5], and were performed using the same equipment and catheter manometer systems reported previously. Postoperatively, the left ventricle was catheterized using a transseptal technique in all the patients.…”

Section: Cardiac Catheterization and Measurementsmentioning

confidence: 99%

Left ventricular mass: impact on left ventricular contractile function and its reversibility in patients undergoing aortic valve replacement

Taniguchi

Takahashi

Toda

et al. 2007

European Journal of Cardio-Thoracic Surgery

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Left ventricular ejection performance, wall stress, and contractile state in aortic regurgitation before and after aortic valve replacement.

Cited by 77 publications

References 43 publications

Study of Left Ventricular Diastolic Diameter–peak Stress Relationship Before and After Valve Replacement Operation for Patients With Chronic Aortic Regurgitation

Study of Left Ventricular Diastolic Diameter–peak Stress Relationship Before and After Valve Replacement Operation for Patients With Chronic Aortic Regurgitation

Mechanism of Beneficial Effects of Restrictive Mitral Annuloplasty in Patients With Dilated Cardiomyopathy and Functional Mitral Regurgitation

Left ventricular mass: impact on left ventricular contractile function and its reversibility in patients undergoing aortic valve replacement

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