Left ventricular ejection fraction in severe chronic obstructive airways disease

Steele, Peter; Ellis, James H.; Dyke, D. Van; Sutton, Frank C.; Creagh, Edward; Davies, Hywel

doi:10.1016/0002-9343(75)90317-4

Cited by 84 publications

(19 citation statements)

References 23 publications

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“…A working hypothesis to account for the high prevalence of LV systolic dysfunction in patients with COPD is that low-grade systemic inflammation accelerates progression of coronary atherosclerosis, which ultimately results in ischemic cardiomyopathy. Such a hypothesis fits the clinical observation of a high incidence of LV wall motion abnormalities noted in patients with COPD and LV dysfunction (19). Uncovering CHF during COPD exacerbation.…”

supporting

confidence: 81%

Diagnostic and Therapeutic Challenges in Patients With Coexistent Chronic Obstructive Pulmonary Disease and Chronic Heart Failure

Jemtel

Padeletti

Jelić

2007

Journal of the American College of Cardiology

267

157

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Chronic obstructive pulmonary disease (COPD) and heart failure (CHF) are common conditions. The prevalence of COPD ranges from 20% to 30% in patients with CHF. The diagnosis of CHF can remain unsuspected in patients with COPD, because shortness of breath is attributed to COPD. Measurement of plasma B-type natriuretic peptide (BNP) levels helps to uncover unsuspected CHF in patients with COPD and clinical deterioration. Noninvasive assessment of cardiac function may be preferable to BNP to uncover unsuspected left ventricular (LV) systolic dysfunction in patients with stable COPD. Patients with COPD or CHF develop skeletal muscle alterations that are strikingly similar. Functional intolerance correlates with severity of skeletal muscle alterations but not with severity of pulmonary or cardiac impairment in COPD and CHF, respectively. Improvement of pulmonary or cardiac function does not translate into relief of functional intolerance in patients with COPD or CHF unless skeletal muscle alterations concomitantly regress. The mechanisms responsible for skeletal muscle alterations are incompletely understood in COPD and in CHF. Disuse and low-level systemic inflammation leading to protein synthesis/degradation imbalance are likely to contribute. The presence of COPD impacts on the treatment of CHF, as COPD is still viewed as a contraindication to beta-blockade. Therefore, COPD often deprives patients with CHF due to LV systolic dysfunction of the most beneficial pharmacologic intervention. A large body of data indicates that patients with COPD tolerate well selective beta-blockade that should not be denied to CHF patients with concomitant COPD.

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supporting

confidence: 81%

Diagnostic and Therapeutic Challenges in Patients With Coexistent Chronic Obstructive Pulmonary Disease and Chronic Heart Failure

Jemtel

Padeletti

Jelić

2007

Journal of the American College of Cardiology

267

157

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“…No correlation was found between Pa02 and both systolic and diastolic indices of left ventricular function, in perfect agreement with the results obtained by Steele et al [13]. A moderate hypoxia seems, thus, unable to affect the left ventricular performance signifi cantly and, as a consequence, is of no value to predict it.…”

Section: Discussionsupporting

confidence: 87%

“…Left ventricular function in chronic respi ratory failure (CRFj has been investigated by several authors employing both invasive [1][2][3][4][5][6][7][8][9][10][11][12] and noninvasive [2,[12][13][14][15][16][17][18] methods. Al though definitive conclusions have not yet been drawn, available evidence suggests that left ventricular dysfunction, when present, is due to other heart diseases [19,20] such as coronary artery disease and hypertension [ 13,21].…”

Section: Introductionmentioning

confidence: 99%

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A Simple Method of Predicting Left Ventricular Function in Stabilized Chronic Respiratory Failure

et al. 1985

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A simple method of assessing left ventricular function in stabilized chronic respiratory failure (CRF) is proposed. 21 patients with CRF were ranked according to the prediction of left ventricular function derived from eight elementary clinical criteria including standard chest X-ray and conventional basal electrocardiography. Equilibrium radionuclide angiocardiography was performed at rest (rERNA) for the evaluation of left ventricular systolic function (ejection fraction, LVEF; peak ejection rate) and diastolic function (peak filling rate). Right ventricular ejection fraction (RVEF) was also measured. The clinical evaluation of the left ventricular function showed a high correlation with rERNA data (p < 0.01 by Spearman’s rank test). No correlation was found between rERNA parameters and PaCo₂and between RVEF and LVEF. The clinical criteria proposed can thus predict left ventricular function in stabilized CRF with a high degree of confidence.

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“…Such a hypothesis is based on the fact that patients with COPD have higher elevation of inflammatory markers [56,57] , and it fits the clinical observation of a higher incidence of troponin elevation [56] and left ventricular wall motion abnormalities [58] noted in patients with COPD and left ventricular dysfunction. Patients with HF and concomitant COPD have higher activation of neurohormones, particularly norepinephrine and plasma rennin [56] .…”

Section: Chronic Obstructive Pulmonary Disease and Heart Failurementioning

confidence: 92%

Köpeklerde Geriatrik Kardiyoloji - Bölüm 2: Geriatrik Köpeklerde Kalp Yetmezliği Tedavisinde Zorluklar: İlaç Reaksiyonları ve Komorbitler

Turgut¹,

Suleymanoglu²,

Ertan³

et al. 2017

Kafkas Univ Vet Fak Derg

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How to Cite This Article AbstractIn geriatric dogs, aging-specific changes in cardiovascular physiology, drug metabolism, drug pharmacokinetics and drug tolerance contribute to adverse drug reactions (ADRs). Comorbidities can also cause polypharmacy and thus drug-drug interactions. Adverse drug reactions for ACE inhibitors, β-blockers, furosemide, aldosterone antagonists and digoxin are common. Geriatric cardiology epitomizes the principle that cardiovascular disease is only 1 component of a larger, multidimensional disease state with concomitant geriatric syndromes. Comorbidities (cardiorenal syndrome, hypertension, diabetes mellitus, atherosclerotic disease, metabolic syndrome, obesity, chronic obstructive pulmonary disease and frailty and cognitive dysfunction) are common, aggravate HF, complicate therapy and increase the total heart failure burden.

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Left ventricular ejection fraction in severe chronic obstructive airways disease

Cited by 84 publications

References 23 publications

Diagnostic and Therapeutic Challenges in Patients With Coexistent Chronic Obstructive Pulmonary Disease and Chronic Heart Failure

Diagnostic and Therapeutic Challenges in Patients With Coexistent Chronic Obstructive Pulmonary Disease and Chronic Heart Failure

A Simple Method of Predicting Left Ventricular Function in Stabilized Chronic Respiratory Failure

Köpeklerde Geriatrik Kardiyoloji - Bölüm 2: Geriatrik Köpeklerde Kalp Yetmezliği Tedavisinde Zorluklar: İlaç Reaksiyonları ve Komorbitler

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