Left ventricular diastolic function evaluated with tissue Doppler imaging in children with familial Mediterranean fever

Baysal, Tamer; Peru, Harun; Oran, Bülent; Şahin, Tahir Kemal; Köksal, Yavuz; Karaaslan, Sevim

doi:10.1007/s10067-008-0976-z

Cited by 17 publications

(20 citation statements)

References 23 publications

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“…Noninvasive diagnostics of the left ventricular diastolic dysfunction in pediatric patients is still based on conventional echocardiographic Doppler parameters. The literature provides few reports on usage of TDI parameters in the assessment of left ventricular diastolic function in children with various pathologies that may lead to diastolic heart failure [10–16]. …”

Section: Introductionmentioning

confidence: 99%

Assessment of left ventricular diastolic function in children after successful repair of aortic coarctation

Floriańczyk

Werner

2010

Clin Res Cardiol

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The purpose of the study was an assessment of left ventricular diastolic function in children after the successful repair of aortic coarctation (CoA). The prospective study concerned 32 pediatric patients after the CoA surgery. Tissue Doppler imaging parameters including strain and strain rate and the conventional echocardiographic indexes were analyzed in patients and healthy controls. Analysis of mitral annulus velocities, E–E′ ratio, strain, and strain rate of left ventricular mid-cavity segments and conventional indexes of mitral inflow showed the worsening of left ventricular diastolic mechanics in the study group compared to healthy controls. The E/E′ ratio was significantly higher in the study group compared to the control group (8.30 ± 3.24 vs. 6.95 ± 1.36; p < 0.05). The early diastolic strain rate to late diastolic strain rate ratio as well as early to late diastolic strain ratio of the left ventricular mid-cavity segments were significantly lower in the study group compared to healthy controls (1.81 ± 0.63 vs. 3.74 ± 1.53; p < 0.001 and 1.20 ± 0.49 vs. 3.41 ± 1.26; p < 0.001). No differences of the pulmonary venous flow parameters between those two groups were observed. The left ventricular diastolic mechanics in hypertensive patients after CoA repair did not differ from normotensive subjects. Hypertensive and normotensive children after surgical repair of CoA are found to have worsening of the left ventricular diastolic mechanics suggesting the impairment of the active myocardial relaxation.

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Section: Introductionmentioning

confidence: 99%

Assessment of left ventricular diastolic function in children after successful repair of aortic coarctation

Floriańczyk

Werner

2010

Clin Res Cardiol

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“…On the other hand, cardiac function has been investigated in children with FMF by using conventional & tissue Doppler imaging [3]. Systolic function was found to be normal, while diastolic dysfunction was reported.…”

Section: Discussionmentioning

confidence: 99%

“…It is a genetic disorder inherited as an autosomal recessive disease [2] and is characterized by recurrent febrile inflammatory attacks of serosal and synovial membranes. FMF predominantly affects the populations arising from the Mediterranean basin and seen in nearly every country [3]. Its phenotype includes recurrent attacks of peritonitis, pleuritis, pericarditis, synovitis, arthritis, and fever [4].…”

Section: Introductionmentioning

confidence: 99%

“…Impairment of diastolic function parameters [3], pericarditis and pericardial effusion [7], atrial mechanical delay, increased P wave dispersion [8], and impaired coronary microvascular function [2], have all been reported in various studies. The present work aimed at defining the frequency and spectrum of cardiac manifestations in Egyptian children with FMF.…”

Section: Introductionmentioning

confidence: 99%

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MEFV gene mutations and cardiac phenotype in children with familial Mediterranean fever: a cohort study

et al. 2014

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BackgroundFamilial Mediterranean fever (FMF) is the most common autoinflammatory disorder in the world. It is characterized by recurrent febrile inflammatory attacks of serosal and synovial membranes. MEFV gene mutations are responsible for the disease and its protein product, pyrin or marenostrin, plays an essential role in the regulation of the inflammatory reactions. Although the disease may carry a potential for cardiovascular disorders because of sustained inflammation during its course, the spectrum of cardiac involvement in children with FMF has not been well studied. We aimed at defining the frequency and spectrum of cardiac affection in children with FMF. The correlation between these affections and MEFV gene mutations was searched for to establish the relationship between cardiac phenotype and the patient's genotype in FMF.MethodsThe present work is a cohort study including 55 patients with the clinical diagnosis of FMF based on the Tel-Hashomere criteria, confirmed by genetic analysis showing homozygous or compound heterozygous mutation of MEFV genes. Fifty age- and sex-matched normal children were included as controls. The entire study group underwent detailed cardiac examination, 12-lead ECG and echocardiography. All data was statistically analysed using SPSS version-15.ResultsPatients had an average age of 8.5+/−4.2 years; with an average disease duration of 2.1+/−2.2 years; 28 were males. All controls showed no MEVF gene mutations. The most frequent gene mutation of the studied cases was E148Q mutation seen in 34% of cases and the most frequent compound mutation was E148Q/V726A seen in 16.6% of cases. Echocardiographic examination revealed pericardial effusion in nine patients. Twelve had aortic regurgitation; nine had mitral regurgitation and six had pulmonary regurgitation. The most common mutation associated with pericardial effusion was E148Q/V726A in 5/9 of cases. Valvular involvement were significantly more common in FMF patients with gene mutations. Also cardiac involvement was more common in patients with positive consanguinity. However, these cardiac manifestations showed no correlation to age, family history of FMF, or response to therapy or laboratory data.ConclusionsIn our cohort of children with FMF, cardiac involvement appears to be common. Pericardial effusions are significantly related to presence of mutation types E48Q, P 369S, V726A. These associations may warrant genetic screening of children with FMF to detect cardiac risk.

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“…8 There are some studies that claim FMF is in association with diastolic dysfunction. 9,10 However, myocardial function has been investigated in FMF patients and diverse results were obtained from different studies. In a study, FMF was found to be in relation with reduced left ventricular (LV) strain in children, 11 but there is lack of research that shows the relationship between FMF and systolic function in adults.…”

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confidence: 99%

Effects of Familial Mediterranean Fever on Cardiac Functions in Adults: A Cross-Sectional Study Based on Speckle Tracking Echocardiography

et al. 2019

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Objectives: This study aims to evaluate the right ventricular (RV) and left ventricular (LV) systolic and diastolic functions with speckle tracking echocardiography in addition to routine echocardiographic measurements in adult familial Mediterranean fever (FMF) patients in order to detect cardiac functions. Patients and methods: Sixty FMF patients (23 males, 37 females; median age 35 years; interquartile range, 26 to 38 years) and 20 healthy subjects (10 males, 10 females; median age 31 years; interquartile range, 25 to 35 years) were included in the study. The diagnosis was established according to the Tel-Hashomer criteria. All patients were using regular colchicine and they were in the attack-free period. Laboratory examinations included complete blood count, creatinine, and inflammatory markers. In addition to routine echocardiographic examination, RV and LV global longitudinal strains were measured and compared. Results: Erythrocyte sedimentation rate and C-reactive protein values were higher in FMF group. LV global longitudinal strain was similar among the groups. FMF patients had slightly lower early diastolic trans-mitral flow (E) values than controls. As similar as the mitral E flow, tricuspid E flow was slightly lower in FMF groups than controls. RV ejection fraction was similar and in normal ranges among the groups. RV global longitudinal strain was lower in FMF group than controls. RV Myocardial Performance Index (or Tei index) was higher in FMF group. Conclusion: The present study indicates low values of mean RV global longitudinal strain and higher Tei index in FMF patients. These results suggest that FMF may cause subclinical RV deterioration.

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Left ventricular diastolic function evaluated with tissue Doppler imaging in children with familial Mediterranean fever

Cited by 17 publications

References 23 publications

Assessment of left ventricular diastolic function in children after successful repair of aortic coarctation

Assessment of left ventricular diastolic function in children after successful repair of aortic coarctation

MEFV gene mutations and cardiac phenotype in children with familial Mediterranean fever: a cohort study

Effects of Familial Mediterranean Fever on Cardiac Functions in Adults: A Cross-Sectional Study Based on Speckle Tracking Echocardiography

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