Left Ventricular Diastolic Function Assessment of a Heterogeneous Cohort of Pulmonary Arterial Hypertension Patients

Hernández-Suárez, Dagmar F.; Menendez, Francisco R. Lopez; Palm, Denada; López‐Candales, Angel

doi:10.14740/jocmr2925w

Cited by 5 publications

(5 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Em 2016, um estudo analisou as tendências relacionadas à HAP em adultos, nos Estados Unidos, e demonstrou que a hipertensão arterial (5,1-17,1%), a diabetes (4,6-7,8%) e a doença coronariana (15,6-22,3%) são comorbidades frequentemente associadas. A insuficiência cardíaca congestiva (40,7-56,1%) e a doença renal aguda (5,(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20),1%) e crônica (1,1-16,4%) também aparecem como fatores importantes 22 .…”

Section: Discussionunclassified

“…Uma PSAP > 35 mmHg, medida por cateterismo cardíaco direito, corresponde à pressão média da artéria pulmonar > 25 mmHg. Portanto, valores de PSAP ≥ 35 mmHg, medidos pelo ecocardiograma, sugerem HAP, assim como aumento de câmaras direitas, insuficiência tricúspide, movimento paradoxal do septo interventricular e diminuição da complacência do ventrículo esquerdo 3,5 . O ecocardiograma deve ser sempre realizado em caso de suspeita de HAP e pode ser usado para inferir o diagnóstico em doentes nos quais diferentes medidas ecocardiográficas estejam consistentes com o diagnóstico 6 .…”

Section: Introductionunclassified

See 1 more Smart Citation

Hipertensão pulmonar em pacientes com doença renal crônica terminal internados em um hospital de referência em nefrologia do estado do Pará, Brasil

Sousa

Oliveira

Moreira

et al. 2018

Revista Pan-Amazônica de Saúde

View full text Add to dashboard Cite

Hipertensão pulmonar em pacientes com doença renal crônica terminal internados em um hospital de referência em nefrologia do estado do Pará, Brasil Pulmonary hypertension in hospitalized patients with chronic end-stage kidney disease at a referral hospital in nephrology in Pará State, Brazil RESUMO OBJETIVOS: Verificar a existência de hipertensão arterial pulmonar (HAP) entre os pacientes portadores de doença renal crônica (DRC) em hemodiálise e identificar seus perfis clínicos. MATERIAIS E MÉTODOS: Estudo retrospectivo, realizado por meio da análise de prontuários de pacientes internados em um hospital de referência em nefrologia do estado do Pará, Brasil, de janeiro a dezembro de 2014. Pela aplicação de um questionário, foram analisados idade, gênero, comorbidades, motivo da internação, tipo de acesso vascular e informações do ecocardiograma Doppler transtorácico, como a medida da pressão sistólica da artéria pulmonar (PSAP), considerando-se valores ≥ 35 mmHg sugestivos de HAP. RESULTADOS: Dos 101 pacientes investigados, 21,8% apresentavam sinais sugestivos de HAP. Desses, 63,6% pertenciam ao gênero masculino, com média de idade de 60,36 ± 12,35 anos. Constatou-se média de PSAP de 51,13 ± 11,40 mmHg e a maioria das internações foram motivadas por uremia (45,5%) e síndrome coronariana aguda (13,6%). Entre as comorbidades, destacaram-se a hipertensão arterial sistêmica (95,5%) e a diabetes mellitus (50,0%). A maioria dos pacientes usava um acesso vascular de curta permanência do tipo Shilley (95,5%) para hemodiálise, e o desfecho mais reportado foi o óbito (36,4%). CONCLUSÃO: O rastreamento de HAP por ecocardiograma pode ser útil para a avaliação cardiopulmonar entre os pacientes urêmicos, havendo necessidade de estudos prospectivos para melhor esclarecer a relação entre HAP e a terapia de hemodiálise em portadores de DRC.Palavras-chave: Doença Renal Crônica; Hemodiálise; Hipertensão Pulmonar.ABSTRACT OBJECTIVES: To verify the existence of pulmonary arterial hypertension (PAH) among patients with chronic kidney disease (CKD) undergoing hemodialysis, and to identify their clinical profiles. MATERIALS AND METHODS: A retrospective study was carried out by analyzing the medical records of patients admitted to a referral hospital in nephrology in Pará State, Brazil, from January to December 2014. Variables as age, gender, comorbidities, reason for hospitalization, type of vascular access were obtained by a questionnaire and analyzed. In addition, transthoracic Doppler echocardiography information, such as pulmonary artery systolic pressure (PASP), with values ≥ 35 mmHg suggesting PAH, was considered. RESULTS: From the total of 101 patients investigated, 21.8% presented signs suggestive of PAH, and 63.6% of those were male with mean age of 60.36 ± 12.35 years. Mean PASP was 51.13 ± 11.40 mmHg and the majority of hospitalizations were due to uremia (45.5%) and acute coronary syndrome (13.6%). Among the main comorbidities identified, systemic arterial hypertension (95.5%) and diabetes mellitus (50.0%) stand out. Most of ...

show abstract

Section: Discussionunclassified

Section: Introductionunclassified

Hipertensão pulmonar em pacientes com doença renal crônica terminal internados em um hospital de referência em nefrologia do estado do Pará, Brasil

Sousa

Oliveira

Moreira

et al. 2018

Revista Pan-Amazônica de Saúde

View full text Add to dashboard Cite

show abstract

“…Probably, chronic myocardial ischemia caused by arterial constriction was responsible for the cardiac function change, being related with the coronary artery lesion severity. Studies found that for patients with angina pectoris and coronary heart disease, myocardial ischemia degree and cardiac function condition predominantly determined the prognosis 14,15. Relevant vascular revascularization may be conducive to improving the prognosis 16…”

Section: Discussionmentioning

confidence: 99%

Influence of elderly patients’ coronary artery lesion severity on cardiac remodeling and left ventricular function

et al. 2018

View full text Add to dashboard Cite

Objective:To analyze the correlation between coronary artery lesion and cardiac function change among elderly patients with coronary heart disease (CHD).Methods:A total of 171 elderly patients with CHD hospitalized from 2009 to 2016 were selected. Their ultrasonic cardiographic and coronary angiographic data were collected, and the correlation between coronary artery lesion and left ventricular remodeling, systolic and diastolic function was analyzed.Results:Coronary artery lesion among elderly patients with CHD was closely related with left ventricular remodeling and systolic function change, but not significantly correlated with diastolic function change.Conclusion:Coronary artery lesion severity of elderly patients with CHD was an important reason for left ventricular remodeling and cardiac systolic function change. Early intervention of coronary artery disease is of great significance to protect the heart function.

show abstract

“…LV diastolic function was classified as normal (LVDD 0), impaired relaxation (LVDD 1), and pseudonormal pattern (LVDD 2). All echocardiographic parameters including LV volumes, LVEF, left atrial volume index, LV mass, MAPSE, and all Doppler variables used to determine LV diastolic function were measured as previously reported by our group [10, 11].…”

Section: Methodsmentioning

confidence: 99%

Assessment of Mitral Annular Plane Systolic Excursion in Patients With Left Ventricular Diastolic Dysfunction

et al. 2019

Self Cite

View full text Add to dashboard Cite

Background Mitral annular plane systolic excursion (MAPSE) is a well-known surrogate measurement of left ventricular ejection fraction (LVEF) and prognostic factor for many cardiac conditions. However, little is known about its role in assessing LV diastolic function; we therefore sought to identify potential determinants of MAPSE in patients with LV diastolic dysfunction (LVDD). Methods Our echocardiographic database was queried for studies of patients with normal sinus. Patients were allocated into three groups: LVDD 0, LVDD 1 and LVDD 2 in accordance with LVDD stages recommended by the American Society of Echocardiography guidelines. Results A total of 107 echocardiographic studies were included in the study. The mean MAPSE was 1.22 ± 0.32 cm. Groups LVDD 0 (n = 23), LVDD 1 (n = 43), and LVDD 2 (n = 41) were significantly different in most of the studied variables. Particularly, MAPSE differed between the three groups (P < 0.01). A multiple regression analysis showed that age, LVEF and LV mass index were predictors of MAPSE instead of LVDD and left atrial measurements. Finally, a regression model was constructed to predict MAPSE in the studied group showing that age and LVEF explained a 46% of the MAPSE variation. A two-way contour plot was illustrated to ease the model interpretation. Conclusions Age and measures of LV systolic function correlated well with MAPSE. A simplified model to predict MAPSE based on age and LVEF is proposed. Additional studies are needed to examine the potential role of MAPSE in identifying symptoms and overall prognosis in LVDD patients.

show abstract

Left Ventricular Diastolic Function Assessment of a Heterogeneous Cohort of Pulmonary Arterial Hypertension Patients

Cited by 5 publications

References 48 publications

Hipertensão pulmonar em pacientes com doença renal crônica terminal internados em um hospital de referência em nefrologia do estado do Pará, Brasil

Hipertensão pulmonar em pacientes com doença renal crônica terminal internados em um hospital de referência em nefrologia do estado do Pará, Brasil

Influence of elderly patients’ coronary artery lesion severity on cardiac remodeling and left ventricular function

Assessment of Mitral Annular Plane Systolic Excursion in Patients With Left Ventricular Diastolic Dysfunction

Contact Info

Product

Resources

About