Left ventricular diastolic dysfunction in patients with bronchial asthma with long-term oral β2-adrenoceptor agonists

Hirono, Osamu; Minamihaba, Osamu; Fatema, Kaniz; Kato, Shigeaki; Nakamura, Hidenori; Tomoike, Hitonobu

doi:10.1067/mhj.2001.118117

Cited by 29 publications

(17 citation statements)

References 20 publications

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“…They also concluded that; LV diastolic function is impaired in patients with bronchial asthma. Also Hirono et al [28] studied LV diastolic dysfunction in patients with bronchial asthma with long term oral b2-adrenoceptor agonists and found that the regular use of oral b2-adrenoceptor agonists induced left ventricular diastolic dysfunction. Goloskokova et al [29] studied right and left ventricular functions in patients with asthma and found that LV alterations in patients with asthma were minimal and included LV diastolic dysfunction in patients with severe asthma.…”

Section: Discussionmentioning

confidence: 98%

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Echocardiographic evaluation of ventricular function in young adults with bronchial asthma

Abdalla

Azeem

2013

Egyptian Journal of Chest Diseases and Tuberculosis

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Background: Bronchial asthma (BA) is a common chronic inflammatory condition affecting the airways. Bronchial asthma not only affects the lung but also affects other organs including the heart. Right ventricular (RV) hypertrophy and dilation and left ventricular (LV) diastolic dysfunction were observed in severe BA. However, evaluation of ventricular function in this disease by the use of recently proposed Doppler echocardiographic methods has not been extensively studied before.Purpose: The aim of this study was to evaluate ventricular function in young adult patients with BA. Patients and methods: Fifty patients with bronchial asthma and 30 control subjects (mean ages 28.3 ± 7.0 and 26.8 ± 6.2 years, respectively) participated in this study. Systolic function was assessed by subjective evaluation of wall motion for both ventricles and by fractional shortening for the left ventricle (LV). LV diastolic function was evaluated by standard pulsed-wave Doppler echocardiography, myocardial performance index (MPI) and transmitral flow propagation velocity (TFPV). RV function was evaluated by MPI. No subject had signs or symptoms of clinically overt heart failure.Results: Our results revealed that there were statistically significant differences in the peak E velocity, peak E velocity/peak A velocity ratio and isovolumetric relaxation time between the two groups (p < 0.05). Mean LV MPI in the bronchial asthma group (0.40 ± 0.13) was also significantly higher than that of the controls (0.36 ± 0.11, p < 0.05). On the other hand, there were no significant differ-* Corresponding authors. Address: Alhayah National Hospital, Khames Mushyt, Saudi Arabia. Tel.: +966 507378430/+966 545048673; ences in the mean value of peak A velocity, deceleration time and isovolumetric contraction time between bronchial asthma patients and controls. TFPV was significantly reduced in the bronchial asthma group when compared to controls (37.10 ± 2.13 versus 43.40 ± 3.11, respectively, p = 0.001). We observed no significant difference in the echocardiographic indices of RV performance between the two groups. The mean RV MPI in the bronchial asthma group (0.29 ± 0.11) was not significantly different from that of the controls (0.27 ± 0.08).Conclusion: From this study we concluded that LV diastolic function is impaired in patients with bronchial asthma despite no effect on RV diastolic function.

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Section: Discussionmentioning

confidence: 98%

“…This tachycardia may be due to multiple causes including hypoxemia or medications (Mahmoud et al [19]). Hirono et al [28] concluded that Long-term use of oral b2 agonists impaired left ventricular diastolic function in patients with BA, and the cessation of b2 agonists reversed diastolic pump performance to the normal level.…”

Section: Discussionmentioning

confidence: 98%

Echocardiographic evaluation of ventricular function in young adults with bronchial asthma

Abdalla

Azeem

2013

Egyptian Journal of Chest Diseases and Tuberculosis

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“…For these reasons, IPR is used to treat salivation disorders and bronchial asthma, and it is used as a beta-adrenergic receptor agonist. 13,14 In the present study, IPR was administered to mice to release the secretory granules from submandibular gland acinar cells before irradiating them, so that the effect of irradiation on protein synthesis and secretion could be determined histochemically. Savage et al 15 exposed the submandibular glands of rats to a 10-Gy dose of X-ray, and noted marked morphological changes after 3 days, but not after 14 days.…”

Section: Discussionmentioning

confidence: 99%

Radioprotection of the murine submandibular gland by isoproterenol: autoradiography study with 3H-leucine

et al. 2004

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Irradiation of the salivary glands results in the generation of free radicals from metal ions present in the secretory granules of acinar cells, a process that is believed to exacerbate radiation damage to the salivary glands. We therefore conducted a comparative investigation of radiation damage to the acinar cells of murine submaxillary glands in which granule secretion had been induced, and used autoradiography to visualize the pathological changes. Male BALB/c mice, at 8 weeks of age, were divided into four groups: a no-isoproterenol (IPR) and no-irradiation group (group I), a no-IPR, irradiated group (group II), an IPR, no-irradiation group (group III), and an IPR, irradiated group (group IV). Intraperitoneal injections of IPR were used, and 3 h later, the submaxillary region was irradiated with X-rays at a dose of 10 Gy. Three days after the irradiation, 3H-leucine was administered, and submaxillary glands were removed at predetermined times. Thin sections were prepared, and light- and electron-microscope autoradiography was performed. The number of reduced silver particles per unit acinar cell area was determined by light-microscopic autoradiography, and the proportion of reduced silver particles in the rough endoplasmic reticulum, the Golgi apparatus, and secretion granules was determined by electron-microscopic autoradiography. The result indicated that the effects of the radiation on the secretory potential of the submaxillary glands were diminished in acinar cells with a higher secretory granule content.

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“…Она представляет собой универсальную реакцию миокарда на поврежде-ние [4]. ДД является следствием любого состояния, сопровождающегося энергодефицитом, и зависит от множества различных факторов, как физио-логических -возраст [5][6][7], ЧСС [8,9], АД, систо-лическая функция ЛЖ, функция предсердия, активность симпатической и парасимпатической нервной системы, реология крови [10,11], так и па-тологических -интоксикация, нарушение гормо-нального статуса [12]. Применительно к больным кардиохиругического профиля нельзя исключить и влияние самого оперативного вмешательства -нарушение целостности перикарда, частичную денервацию миокарда во время коронарного шун-тирования, ишемическое и реперфузионное ин-траоперационное повреждение миокарда, стан-нирование миокарда в бассейне шунтированных артерий [13].…”

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Left Ventricgle Diastolic Function in Patients After Coronary Bypass Surgery

Титова

Sayganov

2014

Rossiĭskiĭ semeĭnyĭ vrach

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В последние годы предметом исследований клиницистов стали механизмы развития диастолической дисфункции миокарда левого желудочка и ее влияние на течение ишемической болезни сердца. Интерес к данной проблеме в настоящее время обусловлен увеличением объемов и сложности выполняемых опе-раций на открытом сердце. В доступной литературе очень мало данных о синхронности восстановления про цессов расслабления и сокращения миокарда после реваскуляризации. В связи с этим актуальным пред ставляется оценить изменение диастолической функции левого желудочка после коронарного шун-тирования и установить ее возможную взаимосвязь с динамикой систолической функции.Ключевые слова: диастолическая функция, ишемическая болезнь сердца, реваскуляризация. In recent years, clinicians have started to study the mechanisms in development of diastolic dysfunction of the left ventricle and its influence on the course of coronary artery disease. This is a consequence of increasing number and complexity open heart surgery. In the literature, few data about simultaneous recovery processes of relaxation and contractility after revascularization. In this regard, actual to assess diastolic function of the left ventricle after coronary artery bypass graft surgery and to identify a possible connection with changes in systolic function.Keywords: diastolic function, ischemic heart disease, revascularization.Диастолическая функция (ДФ) левого желу-дочка представляет собой совокупность процес-сов расслабления и растяжения, происходящих в диастолу и обеспечивающих диастолическое наполнение левого желудочка (ЛЖ). Диастола длится от момента закрытия аортального клапана до закрытия митрального клапана. Ряд авторов под диастолической функцией понимает способ-ность желудочков к наполнению, которая зависит от двух основных факторов -активного расслаб-ления (релаксации) и пассивных диастолических свойств желудочка, определяющих его способ-ность к растяжению. Последние, в свою очередь, зависят от толщины миокарда, степени его фи-брозирования, инфильтрации и физиологическо-го состояния [1]. Поступление крови в желудочек осуществляется в три фазы -фазу быстрого на-полнения в раннюю диастолу, фазу медленного (пассивного) наполнения и фазу активного напол-нения в конце диастолы во время систолы пред-сердий. Роль предсердий в условиях нормосисто-лии и при отсутствии нарушений диастолического расслабления относительно невелика: вклад си-столы предсердий в сердечный выброс не превы-шает 25%, что позволяет считать ее лишь допол-нительным насосом для наполнения желудочков, однако при прогрессировании хронической сер-дечной недостаточности систола предсердий при-обретает принципиально важную компенсатор-ную роль.Ранняя диастола наступает с периода изоволю-мического расслабления желудочка и приводит к выравниванию давления между предсердием и желудочком, что, в свою очередь, зависит от дав-ления в самом предсердии и скорости расслабле-ния миокарда желудочка. Процесс расслабления определяется скоростью актин-миозиновой дис-социации (активная, энергозависимая часть ре-лаксаци...

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Left ventricular diastolic dysfunction in patients with bronchial asthma with long-term oral β2-adrenoceptor agonists

Cited by 29 publications

References 20 publications

Echocardiographic evaluation of ventricular function in young adults with bronchial asthma

Echocardiographic evaluation of ventricular function in young adults with bronchial asthma

Radioprotection of the murine submandibular gland by isoproterenol: autoradiography study with 3H-leucine

Left Ventricgle Diastolic Function in Patients After Coronary Bypass Surgery

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