Left Ventricular Diastolic Dysfunction as Assessed by Echocardiography in Metabolic Syndrome

Masugata, Hisashi; Senda, Shoichi; Goda, Fuminori; Yoshihara, Yumiko; Yoshikawa, K; Fujita, Norihiro; Daikuhara, Hiroyuki; Nakamura, Hiroyuki; Taoka, Teruhisa; Kohno, Masakazu

doi:10.1291/hypres.29.897

Cited by 62 publications

(61 citation statements)

References 27 publications

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“…All these changes result in the onset of LV There is a dilemma as to whether the levels of glucose and glycated hemoglobin affect the global LV function. Studies have confirmed that this correlation exists 3,5,19 , which was also the result of our study. The separate analysis of the influence MS components in our study also showed that fasting glucose levels, in addition to systolic blood pressure and triglycerides levels, were independently associated with the Tei index.…”

Section: Discussionsupporting

confidence: 92%

“…Triglycerides levels were not independently associated with the Tei index when all clinical and echocardiographic parameters were considered. However, when only MS criteria were considered, triglycerides were independently associated with this index, which is consistent with the findings of other authors 5,19 . Fuentes et al 24 were the first to show that subjects with increased levels of triglycerides had significantly impaired LV diastolic function and increased LV mass, when compared to the control group.…”

Section: Discussionsupporting

confidence: 92%

“…There is no absolute agreement about the impact of age and heart rate on the Tei index 2,3,5,7,16 . Our research showed that the index of global LV function was independent from age, which is very important for the assessment of LV global function in patients of different ages.…”

Section: Discussionmentioning

confidence: 99%

“…Some authors showed that the Tei index correlated with the arterial blood pressure 5,15,19 , while others have disagreed 2,17 . Our investigation revealed that the systolic and diastolic blood pressure correlated with the myocardial performance index, but only systolic blood pressure was independently associated with the Tei index.…”

Section: Discussionmentioning

confidence: 99%

“…The influence of the metabolic syndrome (MS) on global left ventricular function has not been completely determined. There are different opinions on this problem; on the one hand, there are authors who believe that MS is the cluster of risk factors and therefore the alteration of global left ventricular function is an expected and logical sequence 5,6 . On the other hand, some investigators have shown that the Tei index is not significantly altered in patients with a high prevalence of obesity, hypertension and diabetes, which are the important risk factors of metabolic syndrome 7 .…”

Section: Introductionmentioning

confidence: 99%

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Preditores de função ventricular esquerda global na síndrome metabólica

Ivanović

Tadić

Simić

2011

Arq. Bras. Cardiol.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preditores de função ventricular esquerda global na síndrome metabólica

Ivanović

Tadić

Simić

2011

Arq. Bras. Cardiol.

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Association between metabolic syndrome and left ventricular geometric change including diastolic dysfunction

Lee

Kim

et al. 2022

Clinical Cardiology

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Background We investigated the association between individual components of metabolic syndrome (MetS) and left ventricular (LV) geometric changes, including diastolic dysfunction, in a large cohort of healthy individuals. Methods Overall, 148 461 adults who underwent echocardiography during a health‐screening program were enrolled. Geographic characteristics on echocardiography and several markers of LV relaxation function were identified according to individual MetS components. Univariate linear regression analysis and a multivariate regression model adjusted for factors known to influence LV relaxation function were conducted. Results The prevalence of LV diastolic dysfunction (LVDD) was higher in the MetS group than in the non‐MetS group (0.56% vs. 0.27%, p < .001). In univariate and multivariate analyses, E/A ratio, e′ velocity, and left atrial volume index were significantly associated with each component of MetS and covariates (all p ≤ .001). In the age‐ and sex‐adjusted model, MetS was significantly associated with LVDD (odds ratio [95% confidence interval], 1.350 [1.103, 1.652]). However, subjects with more MetS components did not have a significantly higher risk of LVDD. As the analysis was stratified by sex, the multivariate regression model showed that MetS was significantly associated with LVDD only in men (1.3 [1.00, 1.68]) with higher risk in more MetS component ( p for trend < .001). In particular, triglyceride (TG) and waist circumference (WC) among MetS components were significantly associated with LVDD in men. Conclusions MetS was associated with the risk of LVDD, especially in men, with a dose‐dependent association between an increasing number of components of MetS and LVDD. TG and WC were independent risk factors for LVDD in men.

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Myocardial deformation and twist mechanics in adults with metabolic syndrome: Impact of cumulative metabolic burden

Crendal

Walther

Vinet

et al. 2013

Obesity

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Objective: The aim of the study is to characterize left ventricular (LV) myocardial mechanics in adults with metabolic syndrome (MetS), and elucidate the effects of multiple risk-factors on myocardial function using speckle tracking echocardiography (STE); a more sensitive method than conventional echocardiography for detecting subclinical myocardial dysfunction. Design and Methods: Cross-sectional analyses of 92 adults (50-70 years) with MetS, and 50 healthy controls included conventional echocardiography, blood biochemistry, and STE-derived myocardial longitudinal, circumferential, and twist mechanics. Results: Using conventional measures, MetS participants revealed LV hypertrophy and reduced diastolic function compared with controls, while systolic function was preserved. From STE, MetS participants showed attenuated longitudinal strain (216.8% 6 2.8% vs. 220.6% 6 2.7%), and both diastolic (1.1 6 0.2 vs. 1.4 6 0.3 s s 21 ) and systolic (21.0 6 0.1 vs. 21.2 6 0.2 s s 21 ) strain rate (SR). Circumferential strain, SR, and twist mechanics did not differ. Participants with the highest number of MetS factors or diabetes demonstrated the greatest reduction in longitudinal strain and SR. Abdominal obesity, TNF-a, HbA 1c , and systolic dyssynchrony explained 48% of impairment in longitudinal strain. Conclusions: Impaired longitudinal myocardial diastolic and systolic function, but preserved circumferential function and twist mechanics were found in MetS participants, indicative of altered subendocardial function. This dysfunction was best predicted by abdominal obesity, inflammation, glucose-intolerance, and systolic dyssynchrony.

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Left Ventricular Diastolic Dysfunction as Assessed by Echocardiography in Metabolic Syndrome

Abstract: The purpose of the present study was to elucidate the cardiac structure and function in patients who have metabolic syndrome but no history of cardiovascular disease by analyzing echocardiographic findings.

Cited by 62 publications

References 27 publications

Preditores de função ventricular esquerda global na síndrome metabólica

Preditores de função ventricular esquerda global na síndrome metabólica

Association between metabolic syndrome and left ventricular geometric change including diastolic dysfunction

Myocardial deformation and twist mechanics in adults with metabolic syndrome: Impact of cumulative metabolic burden

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