Left ventricular cineangiography in Chagas' disease: Detection of early myocardial damage

Carrasco, Hugo; Barboza, Juan S.; Inglessis, G; Fuenmayor, Abdel J.; Molina, César

doi:10.1016/0002-8703(82)90232-0

Cited by 82 publications

(29 citation statements)

References 14 publications

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“…Survival at 10 years is Ϸ75% to 85%. 21 mortality (50%) at 2 years. In all groups, coronary angiography, when performed, is normal or shows nonsignificant lesions.…”

Section: Chronic Chagas Diseasementioning

confidence: 99%

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Echocardiography in Chagas Heart Disease

2007

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Background-Chagas heart disease is a frequent cause of morbidity and mortality in Latin America. Echocardiography provides useful diagnostic and prognostic information and is an important tool in the management of patients with Chagas disease. Methods and Results-A search for relevant publications was obtained from MEDLINE, LILACS, and SCIELO sources.Acute Chagas myocarditis is a rare disorder in which pericardial effusion is frequent. Echocardiography may exclude pericardial tamponade in case of heart failure. Chronic Chagas cardiomyopathy evolves for several decades after the infection. Epidemiological history, positive serology, and suggestive clinical and ECG abnormalities establish the diagnosis. About three quarters of chronic Chagas cardiomyopathy subjects remain asymptomatic with normal (indeterminate form) or abnormal ECGs. Early Doppler abnormalities includes prolongation of isovolumic contraction and relaxation times. Systolic function frequently is normal, but dysfunction may be elicited by stress tests. Half or more of symptomatic patients have a left ventricular apical aneurysm and other segmental contractile abnormalities similar to those seen in coronary heart disease. The dilated nonsegmental form is indistinguishable from dilated cardiomyopathy. Results from univariate and multivariate Cox survival analyses indicate that impaired systolic function and increased ventricular dimensions have significant value in predicting cardiac morbidity and mortality. Cardiac ultrasound commonly is used in the follow-up of patients and in the assessment of various therapeutic modalities. Conclusions-Echocardiographic and Doppler techniques provide useful structural and functional information in the detection of early myocardial damage, risk assessment of prognosis, disease progression, and management of patients with Chagas disease.

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“…Survival at 10 years is Ϸ75% to 85%. 21 mortality (50%) at 2 years. In all groups, coronary angiography, when performed, is normal or shows nonsignificant lesions.…”

Section: Chronic Chagas Diseasementioning

confidence: 99%

“…About half of these patients may have LV apical and other segmental wall abnormalities. 21,[25][26][27][28][29] Mitral and tricuspid valve regurgitation may be present. Survival at 10 years is Ϸ75% to 85%.…”

Section: Chronic Chagas Diseasementioning

confidence: 99%

Echocardiography in Chagas Heart Disease

2007

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“…As already known, in Chagas' disease, which is characterized by a diffuse myocardial inflammatory process 23 , the apical aneurysm is a very suggestive morphological finding 24 . When the aneurysm is absent, alterations in contractility, which frequently involve the left ventricular posteroinferior wall, may be detected.…”

Section: Discussionmentioning

confidence: 87%

Avaliação quantitativa da movimentação parietal regional do ventrículo esquerdo na endomiocardiofibrose

Mady

Salemi

Ianni

et al. 2005

Arq. Bras. Cardiol.

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ObjectiveTo analyze left ventricular (LV) regional wall motion in patients with endomyocardial fibrosis (EMF). MethodsThe study comprised 88 patients, 59 of the female sex, with a mean age of 39±13 years (range, 9 to 65) and with echocardiographic and angiographic evidence of left ventricular EMF. The intensity of fibrous tissue buildup on contrast cineventriculography was classified as mild, moderate, or severe. The overall left ventricular ejection fraction (LVEF) was determined by using the area-length method on ventriculography. The motion was measured in 100 equidistant chords perpendicular to the centerline drawn in the middle of the final diastolic and systolic contours and normalized to cardiac size. Five left ventricular segments were analyzed: A -apical; AL -anterolateral; AB -anterobasal; IA -inferoapical; IB -inferobasal. Abnormality was expressed in units of standard deviation of the mean motion in a normal population of reference, comprised of 103 patients with normal LV according to clinical and electrocardiographic data, and angiographic standards.

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“…Current work on this matter is underway in our institution, since we have been unable so far to replace the cineventriculogram by any other noninvasive technique for that purpose. 3 The determination of an isocitrate dehydrogenase systemic gradient, which involves sampling of the pulmonary artery and a systemic artery, is not a practical means of recognizing Group I A patients Table Ill).…”

Section: Discussionmentioning

confidence: 99%

Biochemical characterization of myocardial damage in chronic chagas' disease

Carrasco

Olmos

Dipaolo

et al. 1997

Clinical Cardiology

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SummaryBackground: In the early asymptomatic stages of cardioniyopathy in chronic Chagas' disease, septa1 endomyocardial biopsies disclose multiple evidence of evolving myocardial damage. Detection of signs of an active myocardiopathic process may allow a better understanding of the evolution of this and other related dilated cardiomyopathies and provide a means for evaluation of the result of future therapeutic schemes.Hypothesis: This study was designed to explore whether cellular damage caused by Chagas' disease is reflected by changes of certain serum electrolytes, enzymes, and glycoproteins associated with myocardial metabolism, especially in the coronary sinus into which the blood just metabolized by the heart is drained.Merhods: The study included 47 patients (35 men and 12 women, average age 40 years) with positive complement fixation reaction and hemagglutination test for Chagas' disease. The study protocol included medical records, electrocardiographic (ECG) recordings, routine laboratory analysis, chest x-rays, noninvasive cardiac examinations, and cardiac catheterization.Results: In this study, we determined the concentration or activity of 9 electrolytes, 5 glycoprotein fractions, and 12 enzymes related to cardiac metabolism in blood from the coronary sinus, the superior vena cava, the pulmonary and femoral

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Left ventricular cineangiography in Chagas' disease: Detection of early myocardial damage

Cited by 82 publications

References 14 publications

Echocardiography in Chagas Heart Disease

Echocardiography in Chagas Heart Disease

Avaliação quantitativa da movimentação parietal regional do ventrículo esquerdo na endomiocardiofibrose

Biochemical characterization of myocardial damage in chronic chagas' disease

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