Left-right functional difference of the rat dorsal hippocampus for short-term memory and long-term memory

Sakaguchi, Yukitoshi; Sakurai, Yoshio

doi:10.1016/j.bbr.2020.112478

Cited by 25 publications

(31 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, exposure to stress during adolescence may further accelerate the AISLM and enhance the hippocampal expression of the Arc and Syt1 genes. Notably, functional differences exist between the left and right hippocampi of rodents, depending on the demand for short-term or long-term memory ( Shipton et al, 2014 ; Sakaguchi and Sakurai, 2020 ). Due to experimental limitations, we did not consider the left–right anatomical and functional differences of the rodent hippocampus.…”

Section: Discussionmentioning

confidence: 99%

Effects of Prenatal Exposure to Inflammation Coupled With Stress Exposure During Adolescence on Cognition and Synaptic Protein Levels in Aged CD-1 Mice

Zhang

Zhuang

Sun

et al. 2020

Front. Aging Neurosci.

View full text Add to dashboard Cite

Age-associated impairment of spatial learning and memory (AISLM) presents substantial challenges to our health and society. Increasing evidence has indicated that embryonic exposure to inflammation accelerates the AISLM, and this can be attributable, at least partly, to changed synaptic plasticity associated with the activities of various proteins. However, it is still uncertain whether social psychological factors affect this AISLM and/or the expression of synaptic protein-associated genes. Synaptotagmin-1 (Syt1) and activity-regulated cytoskeleton-associated protein (Arc) are two synaptic proteins closely related to cognitive functions. In this study, pregnant CD-1 mice received daily intraperitoneal injections of lipopolysaccharide (LPS) (50 μg/kg) or normal saline at days 15–17 of gestation, and half of the offspring of each group were then subjected to stress for 28 days in adolescence. The Morris water maze (MWM) test was used to separately evaluate spatial learning and memory at 3 and 15 months of age, while western blotting and RNAscope assays were used to measure the protein and mRNA levels of Arc and Syt1 in the hippocampus. The results showed that, at 15 months of age, control mice had worse cognitive ability and higher protein and mRNA levels of Arc and Syt1 than their younger counterparts. Embryonic exposure to inflammation or exposure to stress in adolescence aggravated the AISLM, as well as the age-related increase in Arc and Syt1 expression. Moreover, the hippocampal protein and mRNA levels of Arc and Syt1 were significantly correlated with the performance in the learning and memory periods of the MWM test, especially in the mice that had suffered adverse insults in early life. Our findings indicated that prenatal exposure to inflammation or stress exposure in adolescence exacerbated the AISLM and age-related upregulation of Arc and Syt1 expression, and these effects were linked to cognitive impairments in CD-1 mice exposed to adverse factors in early life.

show abstract

Section: Discussionmentioning

confidence: 99%

Effects of Prenatal Exposure to Inflammation Coupled With Stress Exposure During Adolescence on Cognition and Synaptic Protein Levels in Aged CD-1 Mice

Zhang

Zhuang

Sun

et al. 2020

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

“…Our study also had several limitations. Firstly, it has recently been revealed that left-right anatomical and functional differences exist in the rodent hippocampus (Sakaguchi and Sakurai, 2020). In our study, a considerable amount of brain tissue was needed for the experiment, and because the unilateral hippocampal tissue available to us may not have been enough to meet the needs of the experiment, we did not account for these differences.…”

Section: The Association Between Altered Staufen Expression and Cognimentioning

confidence: 94%

Effects of Embryonic Inflammation and Adolescent Psychosocial Environment on Cognition and Hippocampal Staufen in Middle-Aged Mice

Zhang

et al. 2020

Front. Aging Neurosci.

View full text Add to dashboard Cite

Accumulating evidence has indicated that embryonic inflammation could accelerate age-associated cognitive impairment, which can be attributed to dysregulation of synaptic plasticity-associated proteins, such as RNA-binding proteins (RBPs). Staufen is a double-stranded RBP that plays a critical role in the modulation of synaptic plasticity and memory. However, relatively few studies have investigated how embryonic inflammation affects cognition and neurobiology during aging, or how the adolescent psychosocial environment affects inflammation-induced remote cognitive impairment. Consequently, the aim of this study was to investigate whether these adverse factors can induce changes in Staufen expression, and whether these changes are correlated with cognitive impairment. In our study, CD-1 mice were administered lipopolysaccharides (LPS, 50 µg/kg) or an equal amount of saline (control) intraperitoneally during days 15-17 of gestation. At 2 months of age, male offspring were randomly exposed to stress (S), an enriched environment (E), or not treated (CON) and then assigned to five groups: LPS, LPS+S, LPS+E, CON, and CON+S. Mice were evaluated at 3-month-old (young) and 15-month-old (middle-aged). Cognitive function was assessed using the Morris water maze test, while Staufen expression was examined at both the protein and mRNA level using immunohistochemistry/western blotting and RNAscope technology, respectively. The results showed that the middle-aged mice had worse cognitive performance and higher Staufen expression than young mice. Embryonic inflammation induced cognitive impairment and increased Staufen expression in the middle-aged mice, whereas adolescent stress/an enriched environment would accelerated/mitigated these effects. Meanwhile, Staufen expression was closely correlated with cognitive performance. Our findings suggested embryonic inflammation can accelerate age-associated learning and memory impairments, and these effects may be related to the Staufen expression.

show abstract

“…To the best of our knowledge, the present results are the first to show that HF impairs SA and IA. Both memory tasks are dependent on the integrity of DH (Quevedo et al, 1997;Izquierdo et al, 2000;Dickson et al, 2007;Sakaguchi & Sakurai, 2020) and PFC (Delatour & Gisquet-Verrier, 1996;Giovannini et al, 2005;Torkaman-Boutorabi et al, 2015;Woloszynowska-Fraser et al, 2017), which are interconnected brain regions critical for memory. IA is also dependent on an intact VH, CeA, and BLA (Parent et al, 1992;Roozendaal & McGaugh, 1997;Giovannini et al, 2005;Nobre, 2013), which may account for the finding that HF-induced memory loss appeared more pronounced in the IA task than in SA.…”

Section: Discussionmentioning

confidence: 99%

“…This is supported by the finding that removing extra-maze cues or increasing the interval between arm choices decreases alternation scores (Richman, 1986;Lalonde, 2002). SA is a task that depends on the integrity of the DH (Dillon et al, 2008;Sakaguchi & Sakurai, 2020) and PFC (Delatour & Gisquet-Verrier, 1996;Woloszynowska-Fraser et al, 2017). To assess SA, eat rat was placed in a Y-maze composed of three equally spaced arms (60°; 60 cm x 17.5 cm).…”

Section: Behavioral Measures Of Mood and Memorymentioning

confidence: 93%

A Multi-Gene Synaptic Plasticity Array Identifies Candidate Molecular Underpinnings of Cognitive and Mood Deficits in Rats with Heart Failure

et al. 2020

Preprint

View full text Add to dashboard Cite

Chronic heart failure (HF) is a serious disorder that afflicts more than 26 million patients worldwide. HF is comorbid with depression, anxiety and memory deficits that have serious implications for quality of life and self-care in patients who have HF. Despite evidence that cognitive performance is worse in HF patients with reduced ejection fraction than in HF patients with preserved cardiac function, there are few studies that have assessed the effects of severely reduced ejection fraction (≤40%) on cognition in non-human animal models. Moreover, very limited information is available regarding the effects of HF on genetic markers of synaptic plasticity in brain areas critical for memory and mood regulation. We induced HF in male rats and tested mood and anxiety (sucrose preference and elevated plus maze) and memory (spontaneous alternation and inhibitory avoidance) and measured the simultaneous expression of 84 synaptic plasticity-associated genes in dorsal (DH) and ventral hippocampus (VH), basolateral (BLA) and central amygdala (CeA,) and prefrontal cortex (PFC). We also included the hypothalamic paraventricular nucleus (PVN), which has been implicated in neurohumoral activation in HF. Our results show that rats with severely reduced ejection fraction displayed signs of polydipsia, anhedonia, increased anxiety, and impaired memory in both tasks. HF also produced a drastic downregulation of synaptic-plasticity genes in PFC and PVN, moderate decreases in DH and CeA and minimal effects in BLA and VH. Collectively, these findings identify candidate brain areas and molecular mechanisms underlying HF-induced disturbances in mood and memory.

show abstract

Left-right functional difference of the rat dorsal hippocampus for short-term memory and long-term memory

Cited by 25 publications

References 17 publications

Effects of Prenatal Exposure to Inflammation Coupled With Stress Exposure During Adolescence on Cognition and Synaptic Protein Levels in Aged CD-1 Mice

Effects of Prenatal Exposure to Inflammation Coupled With Stress Exposure During Adolescence on Cognition and Synaptic Protein Levels in Aged CD-1 Mice

Effects of Embryonic Inflammation and Adolescent Psychosocial Environment on Cognition and Hippocampal Staufen in Middle-Aged Mice

A Multi-Gene Synaptic Plasticity Array Identifies Candidate Molecular Underpinnings of Cognitive and Mood Deficits in Rats with Heart Failure

Contact Info

Product

Resources

About