Left–right functional asymmetry of ventral hippocampus depends on aversiveness of situations

Sakaguchi, Yukitoshi; Sakurai, Yoshio

doi:10.1016/j.bbr.2017.02.028

Cited by 24 publications

(18 citation statements)

References 49 publications

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“…There are a variety of mechanisms that could account for the lateralization and functional isolation of these olfactory circuits, including differential effects of neuromodulators and/or synaptic/cellular plasticity. For example, recent work has demonstrated lateralization in hippocampal contributions to memory in rodents 39 , 40 , mediated by asymmetrical synaptic plasticity 40 . There may also be evidence of asymmetry in plasticity in the olfactory system.…”

Section: Discussionmentioning

confidence: 99%

Task-Correlated Cortical Asymmetry and Intra- and Inter-Hemispheric Separation

Cohen

Wilson

2017

Sci Rep

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Cerebral lateralization is expressed at both the structural and functional levels, and can exist as either a stable characteristic or as a dynamic feature during behavior and development. The anatomically relatively simple olfactory system demonstrates lateralization in both human and non-human animals. Here, we explored functional lateralization in both primary olfactory cortex – a region critical for odor memory and perception- and orbitofrontal cortex (OFC) – a region involved in reversal learning- in rats performing an odor learning and reversal task. We find significant asymmetry in both olfactory and orbitofrontal cortical odor-evoked activity, which is expressed in a performance- and task-dependent manner. The emergence of learning-dependent asymmetry during reversal learning was associated with decreased functional connectivity both between the bilateral OFC and between the OFC-olfactory cortex. The results suggest an inter-hemispheric asymmetry and olfactory cortical functional separation that may allow multiple, specialized processing circuits to emerge during a reversal task requiring behavioral flexibility.

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Section: Discussionmentioning

confidence: 99%

Task-Correlated Cortical Asymmetry and Intra- and Inter-Hemispheric Separation

Cohen

Wilson

2017

Sci Rep

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“…Right-left asymmetry of the hippocampus in anxiety has been described on an anatomical, functional and neurochemical level (Spasojevic et al, 2012;Zhang, Chen, Liu, & Feng, 2020). Findings point towards the right hemisphere-dominant behaviour associated with fear and anxiety (Sakaguchi & Sakurai, 2017).…”

Section: Psychological Medicinementioning

confidence: 98%

Socioeconomic deprivation in early life and symptoms of depression and anxiety in young adulthood: mediating role of hippocampal connectivity

Čermáková

Andrýsková²,

Brázdil

et al. 2020

Psychol. Med.

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Background Experience of early-life socioeconomic deprivation (ELSD) may increase the risk of mental disorders in young adulthood. This association may be mediated by structural and functional alterations of the hippocampus. Methods We conducted a prospective cohort study on 122 participants of the European Longitudinal Study of Pregnancy and Childhood. Information about ELSD was collected via questionnaire from mothers during the first 18 months of participants’ lives. At age 23–24, participants underwent examination by structural magnetic resonance imaging, resting-state functional connectivity and assessment of depressive symptoms (Mood and Feelings Questionnaire) and anxiety (Spielberger State-Trait Anxiety Inventory). The association of ELSD with brain outcomes in young adulthood was assessed with correlations, linear regression (adjusting for sex, socioeconomic position and mother's mental health) and moderated mediation analysis. Results Higher ELSD was associated with greater depressive symptoms (B = 0.22; p = 0.001), trait anxiety (B = 0.07; p = 0.02) and lower global connectivity of the right hippocampus (B = −0.01; p = 0.02). These associations persisted when adjusted for covariates. In women, lower global connectivity of the right hippocampus was associated with stronger trait anxiety (B = −4.14; p = 0.01). Global connectivity of the right hippocampus as well as connectivity between the right hippocampus and the left middle temporal gyrus mediated the association between ELSD and trait anxiety in women. Higher ELSD correlated with a lower volume of the right hippocampus in men, but the volume of the right hippocampus was not related to mental health. Conclusions Early preventive strategies targeted at children from socioeconomically deprived families may yield long-lasting benefits for the mental health of the population.

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“…Using some symmetrical structures in the hemispheres might be an idea to apply the two methods simultaneously, e.g., recording multineuronal activity from the right hippocampus and observing live-cell imaging in the contralateral hippocampus. As anatomical symmetry does not necessarily mean any functional symmetry and the functional “asymmetry” of the hippocampus has been reported in several studies (e.g., Sakaguchi and Sakurai, 2017 ), functional symmetry and exact synchronization of activity of the right and left hippocampi should be confirmed before the experiments.…”

Section: What and How Cell Assemblies Encodementioning

confidence: 87%

Multiple Approaches to the Investigation of Cell Assembly in Memory Research—Present and Future

Sakurai

Osako

Tanisumi

et al. 2018

Front. Syst. Neurosci.

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In this review article we focus on research methodologies for detecting the actual activity of cell assemblies, which are populations of functionally connected neurons that encode information in the brain. We introduce and discuss traditional and novel experimental methods and those currently in development and briefly discuss their advantages and disadvantages for the detection of cell-assembly activity. First, we introduce the electrophysiological method, i.e., multineuronal recording, and review former and recent examples of studies showing models of dynamic coding by cell assemblies in behaving rodents and monkeys. We also discuss how the firing correlation of two neurons reflects the firing synchrony among the numerous surrounding neurons that constitute cell assemblies. Second, we review the recent outstanding studies that used the novel method of optogenetics to show causal relationships between cell-assembly activity and behavioral change. Third, we review the most recently developed method of live-cell imaging, which facilitates the simultaneous observation of firings of a large number of neurons in behaving rodents. Currently, all these available methods have both advantages and disadvantages, and no single measurement method can directly and precisely detect the actual activity of cell assemblies. The best strategy is to combine the available methods and utilize each of their advantages with the technique of operant conditioning of multiple-task behaviors in animals and, if necessary, with brain–machine interface technology to verify the accuracy of neural information detected as cell-assembly activity.

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Left–right functional asymmetry of ventral hippocampus depends on aversiveness of situations

Cited by 24 publications

References 49 publications

Task-Correlated Cortical Asymmetry and Intra- and Inter-Hemispheric Separation

Task-Correlated Cortical Asymmetry and Intra- and Inter-Hemispheric Separation

Socioeconomic deprivation in early life and symptoms of depression and anxiety in young adulthood: mediating role of hippocampal connectivity

Multiple Approaches to the Investigation of Cell Assembly in Memory Research—Present and Future

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