Left/right asymmetry of atrophy in semantic dementia

Thompson, Sian; Patterson, Karalyn; Hodges, John R.

doi:10.1212/01.wnl.0000091868.28557.b8

Cited by 339 publications

(312 citation statements)

References 62 publications

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“…More recently, Williams et al [79] have revealed in a group of frontotemporal dementia patients (including both temporal and frontal variants) that semantic breakdown, measured by non-verbal associative knowledge and naming, was mainly correlated with extensive loss of GM volume throughout the left anterior temporal lobe. Our findings also fit with those of Thompson et al [73] who showed different patterns of cognitive disturbances (predominant in the domain of word-finding and person-specific knowledge, respectively) according to the predominantly altered temporal lobe. Other authors have suggested the right temporal lobe to be critical to person-specific knowledge (e.g., [20]).…”

Section: Discussionsupporting

confidence: 92%

Anatomical and functional alterations in semantic dementia: A voxel-based MRI and PET study

Desgranges

Matuszewski

Piolino

et al. 2007

Neurobiology of Aging

138

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Rare studies have used MRI and voxel based morphometry (VBM) to assess atrophy, and only two PET studies used SPM to examine functional changes in semantic dementia (SD). Our aim was to highlight both morphological and functional abnormalities in a same group of 10 SD patients, in the entire brain, using a "state of the art" methodology (optimized VBM procedure, PET data corrected for partial volume effects and voxel based analyses). We also used an extensive neuropsychological battery. We showed that main alterations concerned the left temporal lobe, in accordance with the striking impairment of semantic memory in SD patients, as well as the hippocampal region, which may partly explain their moderate episodic memory deficits. Hypometabolism was more extensive than grey matter loss in both temporal lobes, and specifically concerned the orbitofrontal areas, consistent with the moderate impairment of executive functions and behavioural changes. While PET is more sensitive than MRI, there is striking concordance between morphological and functional abnormalities, which contrast with the discordance observed in Alzheimer"s disease and might be a typical feature of SD.3

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Section: Discussionsupporting

confidence: 92%

Anatomical and functional alterations in semantic dementia: A voxel-based MRI and PET study

Desgranges

Matuszewski

Piolino

et al. 2007

Neurobiology of Aging

138

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“…Thus, 13 SD patients were classified as LTLV (mean age 62.0 ± 6.3 years, nine males, four females) and six as RTLV (mean age 62.5 ± 5.7 years, three males, three females) (see Table 1). This is consistent with previous studies showing that LTLV is roughly three times more prevalent than RTLV (Seeley et al, 2005;Thompson et al, 2003). There was no significant difference between LTLV and RTLV for age, education, sex, and interval between MRI scans (Table 1).…”

Section: 32supporting

confidence: 92%

Atrophy progression in semantic dementia with asymmetric temporal involvement: A tensor-based morphometry study

Brambati

Rankin

Narvid

et al. 2009

Neurobiology of Aging

204

179

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We performed a longitudinal anatomical study to map the progression of gray matter atrophy in anatomically defined predominantly left (LTLV) and right (RTLV) temporal lobe variants of semantic dementia (SD). T1-weighted MRI scans were obtained at presentation and one-year followup from 13 LTLV, 6 RTLV, and 25 control subjects. Tensor-based morphometry (TBM) in SPM2 was applied to derive a voxel-wise estimation of regional tissue loss over time from the deformation field required to warp the follow-up scan to the presentation scan in each subject. When compared to controls, both LTLV and RTLV showed significant progression of gray matter atrophy not only within the temporal lobe most affected at presentation, but also in the controlateral temporal regions (p < 0.05 FWE corrected). In LTLV, significant progression of volume loss also involved the ventromedial frontal and the left anterior insular regions. These results identified the anatomic substrates of the previously reported clinical evolution of LTLV and RTLV into a unique 'merged' clinical syndrome characterized by semantic and behavioral deficits and bilateral temporal atrophy.

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“…Only six patients were found to have greater right temporal atrophy (RTLV), consistent with prior studies suggesting that LTLV is roughly three times more prevalent. 8 The patients with RTLV varied with respect to temporal atrophy severity and asymmetry. Accordingly, from the remaining 19 patients with LTLV, six were chosen to mirror the RTLV group as closely as possible (figure 1).…”

Section: Acquisition Of Mri and Cerebral Volumesmentioning

confidence: 99%

The natural history of temporal variant frontotemporal dementia

Seeley¹,

Bauer²,

Miller³

et al. 2005

Neurology

297

271

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Left/right asymmetry of atrophy in semantic dementia

Abstract: Patients with left and right predominant SD present with distinct behavioral-cognitive profiles. Characterization of these features may assist in the early and accurate diagnosis of SD.

Cited by 339 publications

References 62 publications

Anatomical and functional alterations in semantic dementia: A voxel-based MRI and PET study

Anatomical and functional alterations in semantic dementia: A voxel-based MRI and PET study

Atrophy progression in semantic dementia with asymmetric temporal involvement: A tensor-based morphometry study

The natural history of temporal variant frontotemporal dementia

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