Left renal Ewing's sarcoma: A case study and a review of imaging literature

Babapour, Sara; Mohseni, Iman; Piri, Reza; Basi, Ali

doi:10.1016/j.radcr.2020.01.010

Cited by 3 publications

(6 citation statements)

References 26 publications

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“…[10,11] The clinical manifestations of rEWs are similar to other renal malignant tumors, including lumbago or abdominal pain, hematuria and fever, and nonspecific manifestations such as abdominal mass and weight loss as the disease progresses, in addition, several cases of rEWs were reported in the literature with acute hypertension as the first symptom, which may be related to the secretion of endocrine active substances by tumor. [12][13][14][15] Imaging examination plays an important role in the detection of renal space-occupying lesions, especially CT, which can clearly show the origin, tumor morphology, size and invasion scope of lesions. From the CT data of our present study and literature published, it can be known that the CT signs of rEWs has a certain relative specificity: it is usually presented as a single, large, fuzzy boundary and irregular soft tissue mass in the kidney.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Experience of CT diagnosis and management of primary renal Ewing’s sarcoma: A retrospective analysis of 6 cases and a literature review

Cai

2022

Medicine

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To present the clinical experience of primary renal Ewing's sarcoma/primitive neuroectodermal tumors (rEWs/PNET) admitted to our hospital and systematically review the published literature. A retrospective analysis was performed on patients with pathologically confirmed renal EWs/PNET (rEWs) in our hospital, and the literature on rEWs published in PubMed and Embase databases before March 1, 2022 was searched for analysis. A total of 337 rEWs were included in the statistical analysis, including 6 cases of our patients and 331 cases published in the literature. The common clinical symptoms of rEWs are abdominal pain, hematuria, abdominal mass and so on. computed tomography (CT) plays an important role in the diagnosis of rEWs, and the typical manifestation is a large heterogeneous soft tissue density mass, with a specific "septum-like" enhancement in contrast-enhanced scan. The 2-year overall survival rate of rEWs was 48%, with a median survival time of 18 months. "Septum-like" enhancement on CT can be used as a relatively specific sign for the differential diagnosis of rEWs from Wilms tumor and neuroblastoma. The maximum diameter of the rEWs was usually greater than 10 cm, the clinical symptoms of weight loss, metastasis at diagnosis, tumor thrombogenesis of renal vein or/and inferior vena cava tumor, and the failure to undergo radical nephrectomy were the factors of poor prognosis. The incidence of primary rEWs is low and the prognosis is poor. Early diagnosis and radical nephrectomy combined with chemotherapy is the key to improve the prognosis of patients, and CT plays an important role in early diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Experience of CT diagnosis and management of primary renal Ewing’s sarcoma: A retrospective analysis of 6 cases and a literature review

Cai

2022

Medicine

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“…Ewing's sarcoma is typically a bone or soft tissue, round cell sarcoma of primitive neuroectodermal origin. It rarely occurs as a primary renal neoplasm [1] and exhibits highly aggressive biological behaviour [2]. Fewer than 150 cases are reported till date [3] and most patients are young adults in the age group of 20 to 40 years with rare paediatric case reports.…”

Section: Introductionmentioning

confidence: 99%

Ewing’s sarcoma of the right kidney with multiple metastasis on PET/CT

Singh

Verma

Kakkar

et al. 2023

Egypt J Radiol Nucl Med

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Background Ewing’s sarcoma is categorized as small round cell aggressive tumor which commonly occurs in bone and soft tissue. Primary renal Ewing’s sarcoma is an extremely rare entity and accounts for less than 1% of renal masses. It is characterized by a very aggressive course, with very few reported cases in the literature. Primary renal Ewing’s sarcoma is indistinguishable from renal cell carcinoma on anatomical imaging and therefore need histopathological correlation for confirmation. The positron emission tomography (PET) fused with computed tomography (CT) helps in the evaluation of disease, for staging and metastatic workup. Case presentation We present a case of 48-year-old lady who presented to urology department with difficulty in passing urine for 5 months associated with pain in the right flank region. She had an episode of haematuria 5 months back. Contrast enhanced CT showed a large lobulated heterogeneously enhancing right retroperitoneal mass in renal fossa. Histopathological examination and immunohistochemistry were suggestive of Ewing’s sarcoma. The PET/CT revealed FDG avid right renal mass with lymph nodal and skeletal metastasis. Conclusions Ewing’s sarcoma being aggressive tumour usually present with bone, liver and lung metastasis along with lymph nodal metastasis at time of diagnosis. The 18 F FDG PET/CT helps in diagnosis, staging, appropriate treatment planning, restaging, response evaluation and prognostication of Ewing’s sarcoma.

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“…Ewing's family of tumours (ESFTs), the rarest of oncologic disorders [1], are highly malignant tumours of soft tissue origin. ESFTs are common in adolescents and young adults and occur primarily in the bones or soft tissues of the limbs and rarely in the internal organs [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

“…ESFTs are common in adolescents and young adults and occur primarily in the bones or soft tissues of the limbs and rarely in the internal organs [2][3][4]. ESFTs include Ewing's sarcoma (ES), extraosseous sarcoma, and primitive neuroectodermal tumours (PNETs) [1]. The origin of these tumours is unclear, but they appear to be derived from cells migrating from the neural tube, with different ectodermal or neuronal differentiation abilities [5].…”

Section: Introductionmentioning

confidence: 99%

Extraosseous Ewing's sarcoma/peripheral primitive neuroectodermal tumour of the kidney: a case report and literature review

Nie

2022

BMC Urol

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Background Extraosseous Ewing's sarcoma/peripheral primitive neuroectodermal tumours(EWS/pPNETs) of the kidney are rare. Signs and symptoms are atypical in EWS patients. Presenting symptoms include haematuria, abdominal pain, or a palpable mass. A comprehensive review of the literature shows that it is difficult to make an accurate diagnosis based on physical examination alone. The imaging findings of EWS/pPNETs are nonspecific. We used contrast-enhanced ultrasound (CEUS) to diagnose an EWS/pPNET in our patient, which had never been reported previously to our knowledge. Case presentation This article reports the case of a 20-year-old female with an abdominal mass and gross haematuria for 1 month. The ultrasound revealed a hypoechoic mass with a clear margin at the lower pole in the left kidney. CEUS demonstrated signs of annular enhancement and heterogeneous enhancement of the tumour, and simultaneous wash-in was predominant. Computed tomography images showed an elliptical low-density tumour. The patient underwent a left kidney resection, and the pathological diagnosis was an EWS/pPNET. Twenty-one days after the kidney operation, the patient underwent 8 cycles of a CAV (vinorelbine, ifosfamide, epirubicin) + IE (isocyclophosphamide, etoposide) chemotherapy regimen. Subsequently, radiotherapy (dose: 45 Gy, radiation field:the tumour bed following surgical resection) was administered for nearly 30 days. The patient had no signs of local recurrence or metastasis within a follow-up of 4 years. Conclusions As a radiation-free, inexpensive, convenient, and repeatable examination method, ultrasound was the primary choice for kidney examination. Early CEUS was helpful to make an accurate diagnosis. Surgery and adjuvant radiation or chemotherapy administered in a timely manner can prevent further deterioration.

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Left renal Ewing's sarcoma: A case study and a review of imaging literature

Cited by 3 publications

References 26 publications

Experience of CT diagnosis and management of primary renal Ewing’s sarcoma: A retrospective analysis of 6 cases and a literature review

Experience of CT diagnosis and management of primary renal Ewing’s sarcoma: A retrospective analysis of 6 cases and a literature review

Ewing’s sarcoma of the right kidney with multiple metastasis on PET/CT

Extraosseous Ewing's sarcoma/peripheral primitive neuroectodermal tumour of the kidney: a case report and literature review

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