Left prefrontal neuronavigated electrode localization in tDCS: 10–20 EEG system versus MRI-guided neuronavigation

Witte, Sara De; Klooster, Debby; Dedoncker, Josefien; Duprat, Romain; Remue, Jonathan; Baeken, Chris

doi:10.1016/j.pscychresns.2018.02.001

Cited by 46 publications

(34 citation statements)

References 21 publications

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“…Although these results are preliminary, the relationship between efield intensity and tDCS effects on metabolite concentrations may be relevant and should be further investigated and may be an avenue for establishing dose-response relationships for tDCS. The inter-individual variation of efields beyond the MRS ROI converges with previous evidence of a marked inter-individual variability in terms of efield intensities and their distribution [74,75], and raises the question at which brain regions bifrontal 1 3 montages actually exert their effects. In contrast to our study, Antonenko et al [37] investigated normal components of efield strength (i.e., calculation of the efield including information about the efield entering or leaving the surface which is only available in SimNIBS 2.1) to address polarity effects of the stimulation, showing peaks of efield intensities at the stimulation site which may provide a superior approach for analyzing target specificity.…”

Section: Discussionsupporting

confidence: 77%

Effects of bifrontal transcranial direct current stimulation on brain glutamate levels and resting state connectivity: multimodal MRI data for the cathodal stimulation site

Mezger

Rauchmann

Brunoni

et al. 2020

Eur Arch Psychiatry Clin Neurosci

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Transcranial direct current stimulation (tDCS) over prefrontal cortex (PFC) regions is currently proposed as therapeutic intervention for major depression and other psychiatric disorders. The in-depth mechanistic understanding of this bipolar and non-focal stimulation technique is still incomplete. In a pilot study, we investigated the effects of bifrontal stimulation on brain metabolite levels and resting state connectivity under the cathode using multiparametric MRI techniques and computational tDCS modeling. Within a double-blind cross-over design, 20 subjects (12 women, 23.7 ± 2 years) were randomized to active tDCS with standard bifrontal montage with the anode over the left dorsolateral prefrontal cortex (DLPFC) and the cathode over the right DLPFC. Magnetic resonance spectroscopy (MRS) was acquired before, during, and after prefrontal tDCS to quantify glutamate (Glu), Glu + glutamine (Glx) and gamma aminobutyric acid (GABA) concentration in these areas. Resting-state functional connectivity MRI (rsfcMRI) was acquired before and after the stimulation. The individual distribution of tDCS induced electric fields (efields) within the MRS voxel was computationally modelled using SimNIBS 2.0. There were no significant changes of Glu, Glx and GABA levels across conditions but marked differences in the course of Glu levels between female and male participants were observed. Further investigation yielded a significantly stronger Glu reduction after active compared to sham stimulation in female participants, but not in male participants. For rsfcMRI neither significant changes nor correlations with MRS data were observed. Exploratory analyses of the effect of efield intensity distribution on Glu changes showed distinct effects in different efield groups. Our findings are limited by the small sample size, but correspond to previously published results of cathodal tDCS. Future studies should address gender and efield intensity as moderators of tDCS induced effects.

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Section: Discussionsupporting

confidence: 77%

Effects of bifrontal transcranial direct current stimulation on brain glutamate levels and resting state connectivity: multimodal MRI data for the cathodal stimulation site

Mezger

Rauchmann

Brunoni

et al. 2020

Eur Arch Psychiatry Clin Neurosci

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“…Second, our head models also enable comparison of the neural effects on NIBS protocols in healthy vs. depressed brains. Given the different protocols used for left dorsolateral prefrontal cortex (lDLPFC) targeting with NIBS [21,22], computational modelling using these head models will enable the development of protocols for more selective lDLPFC stimulation in this disorder. Third, EEG source localization also relies on head models to calculate the spatial location of possible current sources in the brain.…”

Section: Introductionmentioning

confidence: 99%

Head models of healthy and depressed adults for simulating the electric fields of non-invasive electric brain stimulation

Boayue¹,

Csifcsák²,

Puonti³

et al. 2018

Preprint

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During the past decade, it became clear that the electric field elicited by non-invasive brain stimulation (NIBS) techniques such as transcranial direct current stimulation (tDCS) and transcranial magnetic stimulation (TMS) are substantially influenced by variations in individual head and brain anatomy. In addition to structural variations in the healthy, several psychiatric disorders are characterized by anatomical alterations that are likely to further constrain the intracerebral effects of NIBS. Here, we present high-resolution realistic head models derived from structural magnetic resonance imaging data of 19 healthy adults and 19 patients diagnosed with major depressive disorder (MDD). By using a freely available software package for modelling the electric fields induced by different NIBS protocols, we show that our head models are well-suited for assessing inter-individual and between-group variability in the magnitude and focality of tDCS-induced electric fields for two protocols targeting the left dorsolateral prefrontal cortex.

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“…In contrast, during the chocolate no-go condition there was no effect of tDCS on inhibitory control, suggesting that consistent pairing of the cue with the response (i.e., always inhibit) may have increased the salience of the cue. Novel techniques such as MRI-guided neuronavigation may enhance the ability to localize tDCS montages and determine the effects of modulating nearby brain regions (De Witte, et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Got chocolate? Bilateral prefrontal cortex stimulation augments chocolate consumption

Falcone

Loughead

et al. 2018

Appetite

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Left prefrontal neuronavigated electrode localization in tDCS: 10–20 EEG system versus MRI-guided neuronavigation

Cited by 46 publications

References 21 publications

Effects of bifrontal transcranial direct current stimulation on brain glutamate levels and resting state connectivity: multimodal MRI data for the cathodal stimulation site

Effects of bifrontal transcranial direct current stimulation on brain glutamate levels and resting state connectivity: multimodal MRI data for the cathodal stimulation site

Head models of healthy and depressed adults for simulating the electric fields of non-invasive electric brain stimulation

Got chocolate? Bilateral prefrontal cortex stimulation augments chocolate consumption

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