Left prefrontal high-frequency rTMS may improve movement disorder in schizophrenia patients with predominant negative symptoms – A secondary analysis of a sham-controlled, randomized multicenter trial

Kamp, Daniel; Engelke, Christina; Wobrock, Thomas; Wölwer, Wolfgang; Winterer, Georg; Schmidt-Kraepelin, Christian; Gäebel, Wolfgang; Langguth, Berthold; Landgrebe, Michael; Eichhammer, Peter; Frank, Elmar; Hajak, Göran; Ohmann, Christian; Verde, Pablo Emilio; Rietschel, Marcella; Ahmed, Rayaz; Honer, William G.; Malchow, Berend; Schneider‐Axmann, Thomas; Falkai, Peter; Hasan, Alkomiet; Cordes, Joachim

doi:10.1016/j.schres.2018.09.017

Cited by 10 publications

(6 citation statements)

References 10 publications

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“…Increased FAA in the active group relative to sham condition suggests that hf-tRNS may normalize hypofunction in these brain regions and thereby alleviate disorganized symptoms. Moreover, research has reported the potential of activation of the left prefrontal cortex by non-invasive brain stimulation to improve extrapyramidal symptoms in schizophrenia patients [ 38 ], possibly through its remote effect on subcortical regions of the dopaminergic system, e.g., increased neural activity in the neostriata system and release of endogenous dopamine in the striatum and putamen [ 39 , 40 , 41 ]. However, little is known about possible effects at subcortical levels of lateral prefrontal cortex stimulation with unidirectional hf-tRNS.…”

Section: Discussionmentioning

confidence: 99%

High-Frequency Transcranial Random Noise Stimulation over the Left Prefrontal Cortex Increases Resting-State EEG Frontal Alpha Asymmetry in Patients with Schizophrenia

Yeh

Huang

Chung

et al. 2022

JPM

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Reduced left-lateralized electroencephalographic (EEG) frontal alpha asymmetry (FAA), a biomarker for the imbalance of interhemispheric frontal activity and motivational disturbances, represents a neuropathological attribute of negative symptoms of schizophrenia. Unidirectional high-frequency transcranial random noise stimulation (hf-tRNS) can increase the excitability of the cortex beneath the stimulating electrode. Yet, it is unclear if hf-tRNS can modulate electroencephalographic FAA in patients with schizophrenia. We performed a randomized, double-blind, sham-controlled clinical trial to contrast hf-tRNS and sham stimulation for treating negative symptoms in 35 schizophrenia patients. We used electroencephalography to investigate if 10 sessions of hf-tRNS delivered twice-a-day for five consecutive weekdays would modulate electroencephalographic FAA in schizophrenia. EEG data were collected and FAA was expressed as the differences between common-log-transformed absolute power values of frontal right and left hemisphere electrodes in the alpha frequency range (8–12.5 Hz). We found that hf-tRNS significantly increased FAA during the first session of stimulation (p = 0.009) and at the 1-week follow-up (p = 0.004) relative to sham stimulation. However, FAA failed to predict and surrogate the improvement in the severity of negative symptoms with hf-tRNS intervention. Together, our findings suggest that modulating electroencephalographic frontal alpha asymmetry by using unidirectional hf-tRNS may play a key role in reducing negative symptoms in patients with schizophrenia.

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Section: Discussionmentioning

confidence: 99%

High-Frequency Transcranial Random Noise Stimulation over the Left Prefrontal Cortex Increases Resting-State EEG Frontal Alpha Asymmetry in Patients with Schizophrenia

Yeh

Huang

Chung

et al. 2022

JPM

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“…In addition, single sessions of rTMS over the right inferior parietal lobe improved fine motor function in SZ ( Walther et al, 2020b ). Finally, a large study using 15 sessions of rTMS over the left dorsolateral prefrontal cortex, to treat negative symptoms in SZ, detected beneficial effects on Parkinsonism in a secondary analysis ( Kamp et al, 2019 ). Currently, several groups are conducting studies targeting catatonia or psychomotor slowing in psychosis with rTMS.…”

Section: Stimulation Techniques Of the Human Sensorimotor Systemmentioning

confidence: 99%

Movement disorder and sensorimotor abnormalities in schizophrenia and other psychoses - European consensus on assessment and perspectives

Walther

Harten

Waddington

et al. 2020

European Neuropsychopharmacology

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“…A systematic review suggested that a high left PFC activation is associated with a positive psychological response to exercise (Silveira et al, 2019). Some studies have shown that high-frequency repetitive transcranial magnetic stimulation (rTMS) increases the cortical excitability in the left DLPFC region to improve the negative symptoms of schizophrenia (Kamp et al, 2019) as well as a major depressive disorder (Corlier et al, 2019). Williams et al (2014) have shown that direct stimulation of the left DLPFC might regulate the parietal attention network and affect the emotional expression of the limbic system.…”

Section: Why Were Multi-sessions Of Tdcs Used?mentioning

confidence: 99%

Transcranial Direct Current Stimulation Over Prefrontal Areas Improves Psychomotor Inhibition State in Patients With Traumatic Brain Injury: A Pilot Study

Zhang

Liu

et al. 2020

Front. Neurosci.

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Objectives: Many post-traumatic patients with minimally conscious state are complicated by psychomotor inhibition state (PIS), which impedes further rehabilitation. The treatment of PIS is not satisfactory. This pilot study aimed to investigate effects of anodal transcranial direct current stimulation (A-tDCS) on PIS in post-traumatic patients and examine the altered cortical activation after tDCS using non-linear electroencephalogram (EEG). Methods:The study included 10 patients with post-traumatic PIS. An A-B design was used. The patients received 4 weeks of sham tDCS during Phase A, and they received A-tDCS over the prefrontal area and left dorsolateral prefrontal cortex (DLPFC) for 4 weeks (40 sessions) during Phase B. Conventional treatments were administered throughout both phases. JFK Coma Recovery Scale-Revised (CRS-R), apathy evaluation scale (AES), and the EEG non-linear indices of approximate entropy (ApEn) and cross approximate entropy (C-ApEn) were measured before Phase A, before Phase B, and after Phase B.Results: After A-tDCS treatment, CRS-R and AES were improved significantly. ApEn and C-ApEn results showed that the local cortical connection of bilateral sensorimotor areas with their peripheral areas could be activated by affected painful stimuli, while bilateral cerebral hemispheres could be activated by the unaffected painfulstimuli condition. Linear regression analysis revealed that the affected sensorimotor cortex excitability and unaffected local and distant cortical networks connecting the sensorimotor area to the prefrontal area play a major role in AES improvement. Conclusion:A-tDCS over the prefrontal area and left DLPFC improves PIS. The recovery might be related to increased excitability in local and distant cortical networks connecting the sensorimotor area to the prefrontal area. Thus, tDCS may be an alternative treatment for post-traumatic PIS.

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Left prefrontal high-frequency rTMS may improve movement disorder in schizophrenia patients with predominant negative symptoms – A secondary analysis of a sham-controlled, randomized multicenter trial

Cited by 10 publications

References 10 publications

High-Frequency Transcranial Random Noise Stimulation over the Left Prefrontal Cortex Increases Resting-State EEG Frontal Alpha Asymmetry in Patients with Schizophrenia

High-Frequency Transcranial Random Noise Stimulation over the Left Prefrontal Cortex Increases Resting-State EEG Frontal Alpha Asymmetry in Patients with Schizophrenia

Movement disorder and sensorimotor abnormalities in schizophrenia and other psychoses - European consensus on assessment and perspectives

Transcranial Direct Current Stimulation Over Prefrontal Areas Improves Psychomotor Inhibition State in Patients With Traumatic Brain Injury: A Pilot Study

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