Left main coronary artery thrombosis revealing angio-Behçet syndrome

Ayari, Jihen; Mourali, Mohamed Sami; Farhati, A.; Mechmèche, Rachid

doi:10.4103/1110-7782.139578

Cited by 10 publications

(8 citation statements)

References 13 publications

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“…Vasculitis is the main mechanism of thrombosis. 8 Patients mainly present with silent myocardial ischemia, angina, myocardial infarction, or congestive heart failure .9 Myocardial ischemia caused by thrombus formation in coronary artery may be the main reason of the chest pain in our patient. The prevalence of pulmonary artery involvement is less than 5%, 10,11 and pulmonary artery involvement is strongly associated with deep vein thrombosis and right heart thrombosis.…”

Section: Discussionmentioning

confidence: 65%

Serious Coronary Thrombosis and Pulmonary Artery Thrombosis Revealing Behçet's Disease

2018

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Behçet's disease is a multisystem inflammatory disorder. Cardiovascular involvement is rare but may present with various manifestations, resulting in high mortality. In this article, we report a young male who had chest pain accompanied by systemic involvement, and was diagnosed of Behçet's disease with serious pulmonary artery and coronary thrombosis by systemic check-up. Finally, the patient was successfully treated with a combination of prednisone and immunosuppressive agents instead of surgery. To our knowledge, this is the first report of concurrent coronary thrombosis and pulmonary artery thrombosis in Behçet's disease patients.

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Section: Discussionmentioning

confidence: 65%

Serious Coronary Thrombosis and Pulmonary Artery Thrombosis Revealing Behçet's Disease

2018

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“…Gürkan et al (5) first reported successful results in treating a patient with a thrombus in LMCA with a tissue plasminogen activator infusion. Ayari et al have reported thrombus regression in treating a thrombus in LMCA in a patient with angio-Behçet disease via infusion of tirofiban for 48 hours (6). Sayin et al have also reported regression of a thrombus in LMCA in patients with protein C and protein S deficiency using tirofiban (7).…”

Section: Discussionmentioning

confidence: 99%

A Case of Left Main Coronary Thrombosis Treated Using Tirofiban

Küçükseymen¹,

Erkal²,

Bayar³

et al. 2017

Cyprus J Med Sci

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The presence of a thrombus in the left main coronary artery is a rare but serious situation. Although there are no clear guidelines for such cases, a coronary artery bypass grafting (CABG) surgery is generally performed. Also, in the literature, there are limited reports on cases treated successfully through percutaneous procedures or medical therapy. In this article, we report the case of a patient with a thrombus in his left main coronary artery, a completely obstructed right coronary artery, and chronic renal failure. Because an immediate CABG was highly risky, the patient was given a tirofiban infusion for 48 hours. After the tirofiban infusion, the patient's thrombus had shrunk and his clinical situation had stabilized, paving the way for a successful surgical intervention.

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“…This complication poses several diagnostic and therapeutic challenges and occurs predominantly in male patients ( 8 , 9 ). Cases of coronary involvement in patients with BD were mainly published from Turkey, Mediterranean Basin, Middle East, and Asian countries ( 10 – 16 ). The age range at the time of presentation varied widely.…”

Section: Introductionmentioning

confidence: 99%

“…Impaired microvascular function is believed to be the cause of coronary events among these patients ( 18 ). A fresh floating thrombus in otherwise angiographically normal coronary arteries has also been documented, suggesting an underlying pro-thrombotic etiology ( 10 ). External compression of a coronary artery by an aneurysmal dilation of the left sinus of Valsalva has also been reported ( 19 ).…”

Section: Introductionmentioning

confidence: 99%

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Cardiac findings in patients with Behçet’s disease: Facts and controversies

2016

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Behçet’s disease (BD) is a systemic vasculitis of unknown etiology. It is characterized by recurrent oral and genital ulcers, uveitis, and a number of systemic manifestations. Although the disease is recognized worldwide, its prevalence is highly variable. A detailed review and analysis of the worldwide published reports on BD showed that not only the prevalence of the disease but also its cardiac complications differ according to the geographic distribution of the studied population. With the exception of France, Greece, Spain, and Italy, very few reports and studies regarding BD have been published from the western countries. Cardiovascular complications are an important cause of poor outcome in patients with BD. Over the past few years, many case reports and studies have been published, providing more facts about these complications. For example, peculiar echocardiographic findings in patients with aortic valve regurgitation and intracardiac thrombi secondary to BD were recently described. The role of these findings in the initial diagnosis of the disease, however, remains to be evaluated. On the other hand, some reports present contradictory results, especially concerning the left ventricular diastolic function, pathogenesis of coronary artery disease, and proper management of the cardiac complications in BD. Importantly, management of these complications is based mainly on the discretion of the treating physician due to the absence of large controlled studies and clear guidelines. This approach sometimes creates inconsistent data and allows controversies to persist. The review presented here will discuss some of the facts and controversies related to cardiac complications in BD.

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Left main coronary artery thrombosis revealing angio-Behçet syndrome

Cited by 10 publications

References 13 publications

Serious Coronary Thrombosis and Pulmonary Artery Thrombosis Revealing Behçet's Disease

Serious Coronary Thrombosis and Pulmonary Artery Thrombosis Revealing Behçet's Disease

A Case of Left Main Coronary Thrombosis Treated Using Tirofiban

Cardiac findings in patients with Behçet’s disease: Facts and controversies

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