Left main coronary artery stenosis as a late complication of percutaneous transluminal coronary angioplasty

Hamad, Nidal; Pichard, Augusto D.; Oboler, Allen; Lindsay, Joseph

doi:10.1016/0002-9149(87)90419-x

Cited by 10 publications

(6 citation statements)

References 4 publications

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“…3,4 This can generate fibrocellular lesions at sites previously angiographically free of disease. 3,5,6 The role of endothelium in the response to mechanical injury has not received great attention to date; most investigations have focused mainly on smooth muscle cells within the media.…”

mentioning

confidence: 99%

Early Growth Response Factor-1 Induction by Injury Is Triggered by Release and Paracrine Activation by Fibroblast Growth Factor-2

Santiago¹,

Lowe²,

Day³

et al. 1999

The American Journal of Pathology

107

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Cell migration and proliferation that follows injury to the artery wall is preceded by signaling and transcriptional events that converge at the promoters of multiple genes whose products can influence formation of the neointima. Transcription factors, such as early growth response factor-1 (Egr-1), with nucleotide recognition elements in the promoters of many pathophysiologically relevant genes, are expressed at the endothelial wound edge within minutes of injury. The mechanisms underlying the inducible expression of Egr-1 in this setting are not clear. Understanding this process would provide important mechanistic insights into the earliest events in the response to injury. In this report, we demonstrate that fibroblast growth factor-2 (FGF-2) is released by injury and that antibodies to FGF-2 almost completely abrogate the activation and nuclear accumulation of Egr-1. FGF-2-inducible egr-1-promoter-dependent expression is blocked by PD98059, a specific inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK)-1/2 (MEK-1/2), as well as by dominant negative mutants of ERK-1/2. Inducible ERK phosphorylation after injury is dependent on release and stimulation by endogenous FGF-2. Antisense oligonucleotides directed at egr-1 mRNA suggest that Egr-1 plays a necessary role in endothelial repair after denudation of the monolayer. These findings demonstrate that inducible Egr-1 expression after injury is contingent on the release and paracrine action of FGF-2.

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mentioning

confidence: 99%

Early Growth Response Factor-1 Induction by Injury Is Triggered by Release and Paracrine Activation by Fibroblast Growth Factor-2

Santiago¹,

Lowe²,

Day³

et al. 1999

The American Journal of Pathology

107

View full text Add to dashboard Cite

show abstract

“…Clinical data on LMD progression or de novo formation are scant and predate the widespread use of PCI techniques for coronary revascularization. The introduction of balloon valvuloplasty in the 1980s led to early reports of LMD progression by several authors with a total of 26 documented cases up to the year 2002 . Data from Kells et al on angiographic follow‐up of patients that had balloon angioplasty showed four of 293 (1.3%) developed clinically significant LMD (two after PTCA of left anterior descending and two after PTCA of the circumflex artery) at six months angiographic follow‐up while the diagnostic catheterization group did not show progression.…”

Section: Discussionmentioning

confidence: 99%

“…The introduction of balloon valvuloplasty in the 1980s led to early reports of LMD progression by several authors with a total of 26 documented cases up to the year 2002. 1,4,[6][7][8][9][10][11][12] Data from Kells et al 1 on angiographic follow-up of patients that had balloon angioplasty showed four of 293 (1.3%) developed clinically significant LMD (two after PTCA of left anterior descending and two after PTCA of the circumflex artery) at six months angiographic follow-up while the diagnostic catheterization group did not show progression. Subsequent to these original reports, only two publications on progression of LMD were found in a PubMed search.…”

Section: Discussionmentioning

confidence: 99%

Left Main Disease Progression Following Left Branch Vessel Percutaneous Intervention in Patients Who Are Referred for Coronary Artery Bypass Grafting

et al. 2014

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“…Catheter-induced lesion formation is not a new condition [1]. Though rare, it is nonetheless a clinically significant event [1,2].…”

mentioning

confidence: 99%

“…Though rare, it is nonetheless a clinically significant event [1,2]. Recent work from this and other groups has provided insights into the pathologic mechanisms underlying these lesions.…”

mentioning

confidence: 99%

Left main coronary artery stenosis after percutaneous transluminal coronary angioplasty: Importance of remaining ?minimally invasive?

Lowe

Chesterman

Khachigian

1999

Cathet. Cardiovasc. Intervent.

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Left main coronary artery stenosis as a late complication of percutaneous transluminal coronary angioplasty

Cited by 10 publications

References 4 publications

Early Growth Response Factor-1 Induction by Injury Is Triggered by Release and Paracrine Activation by Fibroblast Growth Factor-2

Early Growth Response Factor-1 Induction by Injury Is Triggered by Release and Paracrine Activation by Fibroblast Growth Factor-2

Left Main Disease Progression Following Left Branch Vessel Percutaneous Intervention in Patients Who Are Referred for Coronary Artery Bypass Grafting

Left main coronary artery stenosis after percutaneous transluminal coronary angioplasty: Importance of remaining ?minimally invasive?

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