Left Internal Mammary Artery Improves 5-Year Survival in Patients Under 40 Subjected to Surgical Revascularization

Malinowski, Marcin; Mrozek, Roman; Twardowski, Romuald; Biernat, Jolanta; Deja, Marek; Widenka, Kazimierz; Dalecka, Anna-Maria; Kobielusz-Gembala, Iwona; Janusiewicz, Piotr; Woś, Stanisław; Gołba, Krzysztof S.

doi:10.1532/hsf98.20041182

Cited by 9 publications

(4 citation statements)

References 14 publications

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“…The use of other arterial grafts such as the radial artery was proven to be superior to venous grafts for long-term patency, especially on the left coronary system 8. We observed some remarkably good early results in our series.…”

Section: Discussionsupporting

confidence: 56%

The role of genetics in coronary artery bypass surgery patients under 30 years of age

Sarikaya¹,

Aydın²,

Özen³

et al. 2017

CVJA

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SummaryAim:We undertook genetic assessment of coronary artery disease (CAD) in 20 patients aged 30 years or less undergoing coronary artery bypass grafting (CABG) surgery, to investigate the prognostic value of pre-defined genes.Methods:Twenty patients, who underwent CABG surgery between December 2001 and May 2013, were retrospectively analysed to find out the role their genetic make-up played in their disease. We used three genetic diagnostic tests, the plasminogen activator inhibitor (PAI)-1 gene, the A1/A2 polymorphism of glycoprotein IIIa (GpIIIa) gene, and common polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene.Results:The mean age of patients was 26.35 ± 3.51 (19–30) years, and 90% were male (n = 18). One patient had diabetes, three had hypertension, 11 (55%) had dyslipidaemia and 16 (80%) were smokers. Eight of the patients (40%) had left ventricular ejection fraction (LVEF) < 50%, and functional capacity was poor in only two (10%) patients (NYHA III– IV). Follow up was completed in all patients (100%). We found five homozygous and 11 heterozygous mutations in the MTHFR gene, which predisposes individuals to coronary artery disease or deep-vein thrombosis. Eight patients were found to have a GpIIIa gene polymorphism, which is associated with increased risk of myocardial infarction (MI). Fifteen patients had a polymorphism in the promoter region of the PAI-1 gene, which is a major inhibitor of the fibrinolytic system.Conclusion:MTHFR C677T polymorphism, and GpIIIa and PAI-1 genes are risk factors for CAD. In young patients, genetic studies promise to revolutionise early diagnosis, treatment and prevention of CAD and MI.

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Section: Discussionsupporting

confidence: 56%

The role of genetics in coronary artery bypass surgery patients under 30 years of age

Sarikaya¹,

Aydın²,

Özen³

et al. 2017

CVJA

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“…[20] Moreover, IMA is known to be the best arterial graft in CABG procedure with excellent lifepatency rate. [21] However, the comprehensive mechanism explaining its exceptional properties is not well explained. On the other hand, epicardial adipose tissue quality and quantity (thickness) is related with CAD and may help in risk stratification.…”

Section: Discussionmentioning

confidence: 99%

Perivascular adipose tissue from the internal mammary artery in patients with severe coronary artery atherosclerosis

Kowalówka¹,

Machnik²,

Deja³

et al. 2020

Kardiol Pol

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“…5,6,8 The use of other arterial grafts such as radial artery was proven to be superior to vein grafts for long term patency especially on the left coronary system. 9,10 When signifi cant risk factors for the sternal wound complication are present such as IDDM and chronic heavy smoking as the case above, we prefer not to use bilateral IMAs. Furthermore, we feared that the right IMA may be stretched when the distal anastomosis has to be grafted far down onto the PDA branch.…”

Section: Discussionmentioning

confidence: 99%

Coronary Artery Bypass Graft in a Young Adult, An Emerging Phenomenon: A Case Report

Arm¹,

Osm²,

Ar³

et al. 2010

imjm

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A 29-year-old, smoker, diabetic, hypertensive and hypercholesterolemic man was diagnosed of having severe coronary artery disease with a critical left main stem stenosis. On-pump coronary artery bypass graft surgery (CABG) was performed using conduits from the left internal mammary artery as well as the left radial artery and right saphenous vein which were both harvested endoscopically. He was discharged after a week of uneventful recovery. This case emphasizes on the best possible management of conduits selection, intraoperative myocardial protection and the risk factors modification in achieving a long term graft patency and avoiding premature cardiac related death.

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Left Internal Mammary Artery Improves 5-Year Survival in Patients Under 40 Subjected to Surgical Revascularization

Cited by 9 publications

References 14 publications

The role of genetics in coronary artery bypass surgery patients under 30 years of age

The role of genetics in coronary artery bypass surgery patients under 30 years of age

Perivascular adipose tissue from the internal mammary artery in patients with severe coronary artery atherosclerosis

Coronary Artery Bypass Graft in a Young Adult, An Emerging Phenomenon: A Case Report

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