Left heart myxomas

Morgan, David L.; Palazola, Joseph; Reed, William; Bell, Hubert; Kindred, Lynn H.; Beauchamp, Gary D.

doi:10.1016/0002-9149(77)90078-9

Cited by 39 publications

(8 citation statements)

References 24 publications

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“…Each sample was given a two-digit number that reflected the order of its collection (for example, CAR107.03 represents the third specimen collected from the CAR.107 family). Clinical information for most of these families has been reported before (5,10,16,(47)(48)(49)(50)(51)(52)(53)(54).…”

Section: Methodsmentioning

confidence: 99%

“…1]), because conclusive information could not be obtained about Figure 1. Pedigrees of the 11 families included in the study (clinical information in 9 of the 11 kindreds was reported previously: CAR01 [47], CAR02 [48], CAR101 [5,49], CAR102 [36,50], CAR103 [51], CAR104 [52], CAR105 [53,54], CAR107 [10], and CAR108 [16]). Open squares and circles represent unaffected male and female patients, respectively.…”

Section: Methodsmentioning

confidence: 99%

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Carney complex, a familial multiple neoplasia and lentiginosis syndrome. Analysis of 11 kindreds and linkage to the short arm of chromosome 2.

Stratakis

Carney²,

Lin³

et al. 1996

J. Clin. Invest.

429

217

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Carney complex is an autosomal dominant syndrome characterized by multiple neoplasias, including myxomas at various sites and endocrine tumors, and lentiginosis. The genetic defect(s) responsible for the complex remain(s) unknown. We studied 101 subjects, including 51 affected members, from 11 North American kindreds with Carney complex. Blood samples were collected from patients and their family members. Hospital records, photographs, and tissue specimens of deceased individuals were reviewed. DNA was extracted from blood samples, patient-derived cell lines, and/ or paraffin-embedded tissues. Linkage analysis was performed with highly polymorphic microsatellite markers, distributed over areas of the human genome harboring the most likely candidate genes. The most prevalent clinical manifestation in patients with Carney complex was spotty skin pigmentation, similar to that observed in Peutz-Jeghers and other lentiginosis syndromes. Skin and cardiac myxomas, Cushing syndrome, and acromegaly were present in 62, 30, 31, and 8 percent of the patients, respectively. Linkage was obtained for three markers on the short arm of chromosome 2 (2p16), with a maximum two-point lod score of 5.97 at ϭ 0.03 for the marker CA-2 (odds in favor of linkage 10 6 :1). The flanking markers CA7 and D2S378 defined a region of ‫ف‬ 6.4 cM that is likely to contain the gene(s) associated with Carney complex. Candidate genes in the proximity, including the propiomelanocortin and the DNA-mismatch repair hMSH2 genes, were excluded. We conclude that the genetic defect(s) responsible for Carney complex map(s) to the short arm of chromosome 2 (2p16). This region has exhibited cytogenetic aberrations in atrial myxomas associated with the complex, and has been characterized by microsatellite instability in human neoplasias.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Carney complex, a familial multiple neoplasia and lentiginosis syndrome. Analysis of 11 kindreds and linkage to the short arm of chromosome 2.

Stratakis

Carney²,

Lin³

et al. 1996

J. Clin. Invest.

429

217

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“…There is no definite correlation to the different types of tumors, but without exception teratomas are found intrapericardially (2, 29), myxomas intracavitarily. Myxomas, however, are found in all cavities of the heart (3, 2 1 ,2 3 , 27), with a predilection site for the left atrium (75%) (12,20,23). On the other hand, fibromas have been detected intramurally (our case 3) (10.…”

Section: Locationmentioning

confidence: 62%

Primary Heart Tumors in Infancy and Childhood Report of Four Cases and Review of Literature

Schmaltz¹,

Apitz²

1981

Cardiology

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Primary heart tumors are rare. The findings in 4 children with heart tumors are reported: a rhabdomyosarcoma, a rhabdomyoma, a fibroma and a myxoma. The symptoms depend upon the location (intrapericardial, intramural or intracavitary). ECG and X-ray provide no essential diagnostic information; echocardiography can give a decisive diagnostic indication in parietal and intracavitary tumors. Surgery provides a specimen for histology, but the tumor cannot always be removed. The prognosis, therefore, depends upon the result of surgery, but malignant tumors, mostly being diagnosed too late, have a very bad prognosis.

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“…Cardiac myx omas can be sporadic, familial or complex. All of our patients had the sporadic variety, which is the most common [ 15], Although myxomas can rarely be asymp tomatic [1,19,22], most present with one or more symptoms of a classic triad of obstruc tive, embolic or constitutional manifestations [19,20,[23][24][25], The symptoms and signs arc mainly dependent on the size and location of the tumor, and the functional derangement caused by it. Constitutional symptoms are due to the presence of the tumor itself [4,[25][26][27], In all of our patients, 2-DE revealed the Med Principles Pracl 1996:5:198-207 characteristic 'to-and-fro' motion across MV of large pedunculated myxomas which filled the left atrium.…”

Section: Discussionmentioning

confidence: 99%

Cardiac Myxoma – Manifestations and Management: Kuwait Experience and Review of the Literature

Uthaman

Salama²,

Hayat

et al. 1996

Med Principles Pract

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Over the past 14 years, 12 patients were diagnosed as having cardiac myxoma. All cases were sporadic, single, large, left atrial myxomas. These patients presented with nonspecific cardiac and noncardiac manifestations. The majority were misdiagnosed as valvar heart disease at initial evaluation, although echocardiography confirmed the diagnosis of myxoma in all. Prompt surgical excision of the tumor was carried out in 11 patients. Additionally, one of them underwent mitral valve repair. This patient died postoperatively due to a coronary embolism, and reoperation. One patient refused surgery. Of the 10 surviving patients who had operations, 9 remain asymptomatic and in sinus rhythm, while 1 has progressive mitral regurgitation and cardiac failure. Our experience indicates that prompt tumor excision under transesophageal echo guidance, shortly after diagnosis, yields excellent results with low morbidity and mortality.

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Left heart myxomas

Cited by 39 publications

References 24 publications

Carney complex, a familial multiple neoplasia and lentiginosis syndrome. Analysis of 11 kindreds and linkage to the short arm of chromosome 2.

Carney complex, a familial multiple neoplasia and lentiginosis syndrome. Analysis of 11 kindreds and linkage to the short arm of chromosome 2.

Primary Heart Tumors in Infancy and Childhood Report of Four Cases and Review of Literature

Cardiac Myxoma – Manifestations and Management: Kuwait Experience and Review of the Literature

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Left heart myxomas

Cited by 39 publications

References 24 publications

Carney complex, a familial multiple neoplasia and lentiginosis syndrome. Analysis of 11 kindreds and linkage to the short arm of chromosome 2.

Carney complex, a familial multiple neoplasia and lentiginosis syndrome. Analysis of 11 kindreds and linkage to the short arm of chromosome 2.

Primary Heart Tumors in Infancy and Childhood Report of Four Cases and Review of Literature

Cardiac Myxoma &ndash; Manifestations and Management: Kuwait Experience and Review of the Literature

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Product

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Cardiac Myxoma – Manifestations and Management: Kuwait Experience and Review of the Literature