Left-handedness: A marker for decreased survival fitness.

Coren, Stanley; Halpern, Diane F.

doi:10.1037/0033-2909.109.1.90

Cited by 305 publications

(235 citation statements)

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“…Handedness arises from a not fully understood interaction between genetic and environmental factors (see e.g. Annett, 1973;Coren and Halpern, 1991;Annett, 2002;McManus, 2002;McManus and Hartigan, 2007). It has been suggested that the fact that left-handers live in a world primarily inhabited by right-handers leads to the motor cortex differences observed.…”

Section: Discussionmentioning

confidence: 99%

Hand preference influences neural correlates of action observation

Willems

Hagoort

2009

Brain Research

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It has been argued that we map observed actions onto our own motor system. Here we added to this issue by investigating whether hand preference influences the neural correlates of action observation of simple, essentially meaningless hand actions. Such an influence would argue for an intricate neural coupling between action production and action observation, which goes beyond effects of motor repertoire or explicit motor training, as has been suggested before. Indeed, parts of the human motor system exhibited a close coupling between action production and action observation. Ventral premotor and inferior and superior parietal cortices showed differential activation for left-and right-handers that was similar during action production as well as during action observation. This suggests that mapping observed actions onto the observer's own motor system is a core feature of action observation -at least for actions that do not have a clear goal or meaning. Basic differences in the way we act upon the world are not only reflected in neural correlates of action production, but can also influence the brain basis of action observation. IntroductionMost individuals have a strong preference to use either the left or the right hand as dominant hand when performing common activities. This distinguishing feature among individuals is at least partially genetically determined, settles early in development and is observed across cultures (see e.g. Annett, 2002;McManus, 2002). Hand preference has been found to differentially influence the cortical motor production system of left-and right-handers (e.g. Kim et al., 1993;Kloppel et al., 2007). Here we investigated whether analogously, hand preference influences neural correlates of action observation.Research shows that action production and action observation are closely linked at the neural level, most notably in the form of mirror neurons in monkey area F5 in ventral premotor cortex and area PF in inferior parietal cortex (see Rizzolatti et al., 2001; Rizzolatti and Craighero, 2004 for review). Also in humans it was shown that the ventral part of the premotor cortex and the inferior part of the parietal cortex become active during action observation (for review see Rizzolatti et al., 2001;Rizzolatti and Craighero, 2004;Binkofski and Buccino, 2006;Iacoboni and Dapretto, 2006).Compelling evidence for a close link between action production and action observation would be if differences between individuals in terms of motor production lead to different neural correlates during action observation. That is, neural correlates of action observation may be modulated by the motor production 'specifics' of the observer. There is some recent evidence from comparing motor experts to B R A I N R E S E A R C H 1 2 6 9 ( 2 0 0 9 ) 9 0 -1 0 4 ⁎ Corresponding author.

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Section: Discussionmentioning

confidence: 99%

Hand preference influences neural correlates of action observation

Willems

Hagoort

2009

Brain Research

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“…1 Both reduced survival fitness and the presence of social pressures against left-handedness in the beginning of the 20th century have been invoked to explain the declining incidence. 2 Lefthandedness is highly correlated with cerebral asymmetry. Right cerebral dominance occurs in 4% of right-handed individuals compared to 27% of left-handed individuals.…”

Section: Introductionmentioning

confidence: 99%

Parametric and nonparametric genome scan analyses for human handedness

et al. 2003

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We have performed a genome scan using 25 nuclear families consisting of right-handed parents with at least two left-handed children. Handedness was assessed as a qualitative trait using a laterality quotient. Laterality quotients indicate the direction of handedness, which is hand preference for performing unimanual tasks. Both parametric and nonparametric linkage analyses were applied. The parametric analysis using the single-locus genetic model of Klar resulted in four different regions with LOD scores higher than 1. The region on chromosome 10q26 gave a suggestive LOD score of 2.02 at a recombination fraction of 0.05. Nonparametric analysis gave an NPL score for this region of 2.16. However, further fine mapping of the region on chromosome 10q26 failed to obtain a higher LOD score. These results suggest that handedness is a human quantitative trait locus and that the proposed non-Mendelian monogenic models are incorrect.

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“…Cerebral lateralization is the anatomical and functional differentiation between the right and left hemispheres of the brain. The right and left hemispheres have separate functions, and the dominant hemisphere performs these functions better than the other (6)(7)(8)(9). There is a direct relationship between hand preference and right-or left-hemisphere dominance.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Complications Following Impacted Mandibular Third Molar Extraction in Patients with Different Hand Preference

Akyol¹,

Keçecioğlu²

2018

meandros

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Objective: Individual preference of using right or left hand for doing various hand workings, is the most easily observable form of the cerebral lateralization. It was stated that, among the right or left hand dominant individuals, there is an immunological asymetry, and a difference in motor control, visuospatial skills, and in the incidence of a number of disease. The aim of the study was to investigate pain, edema, trismus following the mandibular third molar extraction in patients with different hand preference. Amaç: Bireyin çesitli el işlerini yapmak için sağ veya sol elini tercih etmesi serebral lateralizasyonun en kolay gözlenebilen şeklidir. Sağ veya sol eli dominant olan kişiler arasında motor kontrol, vizyospasyal görevleri yerine getirmede, çeşitli hastalıkların görülme insidansında farklılıklar ve immün asimetri olduğu söylenmiştir. Bu çalışmada, mandibular 3. molar çekimini takiben görülen ağrı, ödem, trismusun el tercihi farklı olan hastalarda değerlendirilmesi amaçlanmıştır. Gereç ve Yöntemler: Çalışmaya, sağ ve sol mandibular gömülü üçüncü molar dişlerin çekiminin gerekli olduğu 43 hasta dahil edildi. Aynı hastadan sağ ve sol mandibular gömülü diş çekimi 30 gün arayla yapıldı. 4 hasta grubu oluşturuldu; 1) El tercihi sol-sağ (sağ mandibular 3.molar dişi çekilen) 2) El tercihi sol-sol 3) El tercihi sağ-sağ 4) El tercihi sağ-sol. Ağrı, ödem ve trismusun operasyondan önce ve sonra karşılaştırılması için ölçümler yapıldı.

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Left-handedness: A marker for decreased survival fitness.

Cited by 305 publications

References 123 publications

Hand preference influences neural correlates of action observation

Hand preference influences neural correlates of action observation

Parametric and nonparametric genome scan analyses for human handedness

Evaluation of Complications Following Impacted Mandibular Third Molar Extraction in Patients with Different Hand Preference

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