Case:We report a 25-year-old insulin-dependent woman with extensive soft tissue infection in the left hand. The tissue cultures grew methicillin-resistant Staphylococcus aureus, and histology identified mucor species. The patient received a course of intravenous liposomal amphotericin B and vancomycin. Wound debridement, intravenous antimicrobial, and timely groin flap coverage to wound salvaged the hand and allowed her to return to daily work.Conclusions:Mucormycosis of the hand is rare and is associated with high morbidity and amputation. Little is known about reconstructing the mucor-infected wounds in hand. The pedicled groin flap is safe and reliable and can reconstruct complex defects on the hand, especially mucor-resultant wounds.