Left but not right hemisphere semantic processing abnormalities in language comprehension in subjects with schizotypy traits

Kostova, Milena; Loye, Claire de; Blanchet, Alain

doi:10.1016/j.psychres.2010.05.006

Cited by 6 publications

(9 citation statements)

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“…Regarding the specific objectives of this study, the lack of group differences in N400 amplitude for Re‐LH‐processed expected words and the presence of a semantic memory effect of comparable magnitude in both groups indicate that the generation of expectations is preserved in subjects with high schizotypal traits, as expected. Interestingly, the present findings only partially corroborate those of a previous behavioral study in subjects with low or high schizotypal traits (Kostova et al., ). Indeed, using the same material and almost the same procedure, these authors reported a comparable semantic memory effect for Re‐LH‐processed stimuli in both groups but increased response times for expected words received by the left hemisphere in subjects with high schizotypal traits.…”

Section: Discussionsupporting

confidence: 88%

“…The increase in response time for expected words received by the Re‐LH observed in Kostova et al. () may thus reflect differences in semantic decision strategies between subjects with high and low scores of schizotypy, rather than difficulties in maintaining initial activation, as proposed by the authors. Our results highlight the usefulness of brain activity measures to better target specific processes.…”

Section: Discussionmentioning

confidence: 72%

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An event‐related potential study of predictive and integrative semantic context processing in subjects with schizotypal traits

et al. 2013

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Context processing abnormalities may explain thought disorder in schizophrenia/schizotypy. This study aimed to assess predictive and integrative context processing in subjects with high or low scores on the Schizotypal Personality Questionnaire (SPQ). The N400 amplitude was recorded during semantic judgment of sentence pairs ending with a lateralized expected or unexpected word from the same or a different category (related and unrelated violation). In both groups, the N400 amplitude was less negative for expected words versus unrelated violations, regardless of which hemisphere received the stimulus, and for related versus unrelated violations, but only for left-hemisphere stimuli. The N400 amplitude for unrelated violations was less negative in subjects with high SPQ scores for both hemispheres. These results indicate that subjects with schizotypal traits use context to predict or integrate congruent words, but fail to inhibit incongruent words.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 72%

An event‐related potential study of predictive and integrative semantic context processing in subjects with schizotypal traits

et al. 2013

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“…Normatively, the left hemisphere is important for accessing dominant meanings of words and the right hemisphere facilitates access to remote meanings (Abdullaev & Posner, 1997). Individuals with schizophrenia-spectrum characteristics rely more on right-hemisphere and less on left-hemisphere language functions than is typical (e.g., Grimshaw, Bryson, Atchley & Humphrey, 2010; Kostova, de Loye, & Blanchet, 2011; Pizzagalli et al, 2001; Taylor et al, 2002), which may lead to increased access to remote meanings and/or using semantic information in an inappropriate or unusual context (Fisher et al, 2004). Right-hemisphere activity in schizotypy has also been associated with enhanced creativity domains, such as divergent (Folley & Park, 2005) and convergent thinking (Weinstein & Graves, 2002), suggesting that schizotypy is associated with hemispheric differences in the use of semantic information.…”

Section: Introductionmentioning

confidence: 99%

Neuropsychological differentiation of adaptive creativity and schizotypal cognition

Fisher¹,

Heller²,

Miller³

2013

Personality and Individual Differences

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Both creativity and schizophrenia-spectrum disorders have been associated with activation of remote semantic concepts, but this activation results in innovative output in one case and communication disturbances in the other. The present study examined the relationship between monitoring semantic information (which relies on executive brain function), creativity, and characteristics of schizotypy in an undergraduate population. Results indicate that executive function differentiates the use of semantic information in creativity and schizotypy. Specification of the balance between executive monitoring and activation of semantic information is important for determining how communication disturbances manifest, and for the measurement of creativity and schizotypy in the general population.

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“…SP paradigm was used in nine of the selected studies, [15][16][17][18][19]21,23,24,28 and five of them used the N400 potential. [15][16][17]24,28 14,19 and one 23 studied negative SP, which might be considered a measure of semantic inhibition.…”

mentioning

confidence: 99%

“…[21][22][23]29,31 Two of them used infrared spectroscopy to evaluate the association To study the association between schizotypy and the activation of semantic networks using the SP paradigm and N400 potential.…”

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confidence: 99%

How semantic deficits in schizotypy help understand language and thought disorders in schizophrenia: a systematic and integrative review

Tonelli

2014

Trends Psychiatry Psychother.

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Introduction: Disorders of thought are psychopathological phenomena commonly present in schizophrenia and seem to result from deficits of semantic processing. Schizotypal personality traits consist of tendencies to think and behave that are qualitatively similar to schizophrenia, with greater vulnerability to such disorder. This study reviewed the literature about semantic processing deficits in samples of individuals with schizotypal traits and discussed the impact of current knowledge upon the comprehension of schizophrenic thought disorders. Studies about the cognitive performance of healthy individuals with schizotypal traits help understand the semantic deficits underlying psychotic thought disorders with the advantage of avoiding confounding factors usually found in samples of individuals with schizophrenia, such as the use of antipsychotics and hospitalizations. Methods: A search for articles published in Portuguese or English within the last 10 years on the databases MEDLINE, Web of Science, PsycInfo, LILACS and Biological Abstracts was conducted, using the keywords semantic processing, schizotypy and schizotypal personality disorder. Results: The search retrieved 44 manuscripts, out of which 11 were firstly chosen. Seven manuscripts were additionally included after reading these papers. Conclusion:The great majority of the included studies showed that schizotypal subjects might exhibit semantic processing deficits. They help clarify about the interfaces between cognitive, neurophysiological and neurochemical mechanisms underlying not only thought disorders, but also healthy human mind's creativity.

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Left but not right hemisphere semantic processing abnormalities in language comprehension in subjects with schizotypy traits

Cited by 6 publications

References 76 publications

An event‐related potential study of predictive and integrative semantic context processing in subjects with schizotypal traits

An event‐related potential study of predictive and integrative semantic context processing in subjects with schizotypal traits

Neuropsychological differentiation of adaptive creativity and schizotypal cognition

How semantic deficits in schizotypy help understand language and thought disorders in schizophrenia: a systematic and integrative review

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