Left atrium phasic impairments in paroxysmal atrial fibrillation patients assessed by cardiovascular magnetic resonance feature tracking

Mojica-Pisciotti, Mary Luz; Panovský, Roman; Masárová, Lucia; Pešl, Martin; Stárek, Zdeněk; Holeček, Tomáš; Feitová, Věra; Opatřil, Lukáš; Doležalová, Katarína; Kincl, Vladimír

doi:10.1038/s41598-022-11233-5

Cited by 6 publications

(4 citation statements)

References 41 publications

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“…

h (t)

was constructed by applying the Reynolds transport theorem 58 to Equation (1) and solving for

h (t)

, to give:

h (t) = {([], \int_{∂Ω} bold-italicF \cdot bold-italicn normald S)}^{- 1} \frac{d V_{LA} (t)}{d t} .

Here,

\partial Ω

denotes the domain boundary,

n

is the surface normal vector, and

d V_{LA} / d t

is the rate of change in LA volume. We considered two scenarios; one where the temporal volume change was based on a generic LA volume curve obtained from the existing literature, 59 and one where this specific rate of change was obtained from the time‐resolved CT images.…”

Section: Methodsmentioning

confidence: 99%

“…Here, ∂Ω denotes the domain boundary, n is the surface normal vector, and dV LA =dt is the rate of change in LA volume. We considered two scenarios; one where the temporal volume change was based on a generic LA volume curve obtained from the existing literature, 59 and one where this specific rate of change was obtained from the time-resolved CT images.…”

Section: Wall Boundary Conditionsmentioning

confidence: 99%

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Impact of left atrial wall motion assumptions in fluid simulations on proposed predictors of thrombus formation

Kjeldsberg,

Albors,

Mill

et al. 2024

Numer Methods Biomed Eng

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Atrial fibrillation (AF) poses a significant risk of stroke due to thrombus formation, which primarily occurs in the left atrial appendage (LAA). Medical image‐based computational fluid dynamics (CFD) simulations can provide valuable insight into patient‐specific hemodynamics and could potentially enhance personalized assessment of thrombus risk. However, the importance of accurately representing the left atrial (LA) wall dynamics has not been fully resolved. In this study, we compared four modeling scenarios; rigid walls, a generic wall motion based on a reference motion, a semi‐generic wall motion based on patient‐specific motion, and patient‐specific wall motion based on medical images. We considered a LA geometry acquired from 4D computed tomography during AF, systematically performed convergence tests to assess the numerical accuracy of our solution strategy, and quantified the differences between the four approaches. The results revealed that wall motion had no discernible impact on LA cavity hemodynamics, nor on the markers that indicate thrombus formation. However, the flow patterns within the LAA deviated significantly in the rigid model, indicating that the assumption of rigid walls may lead to errors in the estimated risk factors. In contrast, the generic, semi‐generic, and patient‐specific cases were qualitatively similar. The results highlight the crucial role of wall motion on hemodynamics and predictors of thrombus formation, and also demonstrate the potential of using a generic motion model as a surrogate for the more complex patient‐specific motion. While the present study considered a single case, the employed CFD framework is entirely open‐source and designed for adaptability, allowing for integration of additional models and generic motions.

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“…

h (t)

was constructed by applying the Reynolds transport theorem 58 to Equation (1) and solving for

h (t)

, to give:

h (t) = {([], \int_{∂Ω} bold-italicF \cdot bold-italicn normald S)}^{- 1} \frac{d V_{LA} (t)}{d t} .

Here,

\partial Ω

denotes the domain boundary,

n

is the surface normal vector, and

d V_{LA} / d t

Section: Methodsmentioning

confidence: 99%

Section: Wall Boundary Conditionsmentioning

confidence: 99%

Impact of left atrial wall motion assumptions in fluid simulations on proposed predictors of thrombus formation

Kjeldsberg,

Albors,

Mill

et al. 2024

Numer Methods Biomed Eng

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show abstract

“…Moreover, in a study conducted on patients with different degrees of diastolic dysfunction, it was shown that LA volumes, and impaired LATF, LAS-r, and LAS-a were significantly associated with the severity of diastolic dysfunction [ 80 ]. Similarly, another study proved that LA phasic function determined by CMR might provide important subclinical information regarding LA remodeling in patients who develop paroxysmal atrial fibrillation [ 81 ].…”

Section: Assessment Of La Function By Cardiac Functional Imagingmentioning

confidence: 99%

Cardiac Resynchronization Therapy and Left Atrial Remodeling: A Novel Insight?

et al. 2023

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Cardiac resynchronization therapy (CRT) restores ventricular dyssynchrony, improving left ventricle (LV) systolic function, symptoms, and outcome in patients with heart failure, systolic dysfunction, and prolonged QRS interval. The left atrium (LA) plays tremendous roles in maintaining cardiac function, being often inflicted in various cardiovascular diseases. LA remodeling implies structural—dilation, functional—altered phasic functions, and strain and electrical—atrial fibrillation remodeling. Until now, several important studies have approached the relationship between LA and CRT. LA volumes can predict responsiveness to CRT, being also associated with improved outcome in these patients. LA function and strain parameters have been shown to improve after CRT, especially in those who were positive responders to it. Further studies still need to be conducted to comprehensively characterize the impact of CRT on LA phasic function and strain, and, also, in conjunction with its impact on functional mitral regurgitation and LV diastolic dysfunction. The aim of this review was to provide an overview of current available data regarding the relation between CRT and LA remodeling.

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“…Two software programs were used for image processing: Image Arena (2D CPA MR, TomTec Imaging Systems GmbH, v4.6.4.40) and cvi42 (v5.13.9, Circle Cardiovascular Imaging). The left atrium (LA) was analyzed in Image Arena as described previously [20]. The parameters included the minimum LA volume index (LAVImin), maximum LA volume index (LAVImax), and LA volume index before LA contraction (LAVIpac).…”

Section: Cmr Data Analysismentioning

confidence: 99%

Parkinson´s disease cardiovascular symptoms: A new complex functional and structural insight

Kincl,

Panovský,

Bočková

et al. 2023

Euro J of Neurology

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BackgroundThe known impairments of the cardiovascular system in Parkinson´s disease (PD) are caused by autonomic dysfunction and manifested mainly in postural hypotension, chronotropic insufficiency, and reduced heart rate variability. Other dysfunctions, mainly stress response, arrhythmia occurrence, and heart morphology changes, are still the subject of research.ObjectivesTo assess the heart rate and blood pressure reaction during exercise, advanced measurements of heart volumes and mass using cardiac magnetic resonance (CMR), and occurrence of arrhythmias in PD patients.MethodsThirty PD patients (19 men, mean age 57.5 years) without known cardiac comorbidities underwent bicycle ergometry, electrocardiogram Holter monitoring and CMR. Exercise and CMR parameters were compared with controls (24 subjects for ergometry, 20 for CMR).ResultsPD patients had lower baseline systolic blood pressure (SBP) (117.8 vs. 128.3 mmHg, p < 0.01), peak SBP (155.8 vs. 170.8 mmHg, p < 0.05), and lower heart rate increase (49.7 vs. 64.3 beats per minute, p < 0.01). PD patients had higher indexed left and right ventricular end‐diastolic volumes (68.5 vs. 57.3, p = 0.003 and 73.5 vs. 61.0 mL/m2, respectively) and also indexed left and right ventricular end‐systolic volumes (44.1 vs. 39.0, p = 0.013 and 29.0 vs. 22.0 mL/m2, p = 0.013, respectively). A high prevalence of atrial fibrillation (8 subjects, 26.7%) was found.ConclusionsThis novel study combining functional and structural approaches showed that PD is linked with weaker blood pressure and heart rate reaction during exercise, increased myocardial mass and heart volumes compared to controls, and a high prevalence of atrial fibrillation.

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Left atrium phasic impairments in paroxysmal atrial fibrillation patients assessed by cardiovascular magnetic resonance feature tracking

Cited by 6 publications

References 41 publications

Impact of left atrial wall motion assumptions in fluid simulations on proposed predictors of thrombus formation

Impact of left atrial wall motion assumptions in fluid simulations on proposed predictors of thrombus formation

Cardiac Resynchronization Therapy and Left Atrial Remodeling: A Novel Insight?

Parkinson´s disease cardiovascular symptoms: A new complex functional and structural insight

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