Left atrial volume index in patients with heart failure and severely impaired left ventricular systolic function: the role of established echocardiographic parameters, circulating cystatin C and galectin-3

Zivlas, Christos; Triposkiadis, Filippos; Psarras, Stelios; Giamouzis, Grigorios; Skoularigis, Ioannis; Chryssanthopoulos, Stavros; Kapelouzou, Alkistis; Ramcharitar, Steve; Barnes, Edward L.; Papasteriadis, E.; Cokkinos, Dennis V.

doi:10.1177/1753944717727498

Cited by 21 publications

(20 citation statements)

References 44 publications

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“…Furthermore, the overexpressed osteopontin (Mavroidis and Capetanaki 2002), an integrin-binding multifunctional cytokine and matricellular protein, seems to promote fibrosis and cardiac dysfunction in this model (Psarras et al 2012). Importantly, it also promotes the cardiac expression of additional remodeling modulators such as MMP12 and Galectin-3 (Psarras et al 2012), the latter being recently emerged as a HF biomarker with remarkable performance in predicting cardiovascular events and deaths (Imran et al 2017;Zivlas et al 2017). This carbohydrate-binding Fig.…”

Section: Contribution To Cardiac Fibrosis and Inflammationmentioning

confidence: 91%

Intermediate filaments in cardiomyopathy

et al. 2018

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Intermediate filament (IF) proteins are critical regulators in health and disease. The discovery of hundreds of mutations in IF genes and posttranslational modifications has been linked to a plethora of human diseases, including, among others, cardiomyopathies, muscular dystrophies, progeria, blistering diseases of the epidermis, and neurodegenerative diseases. The major IF proteins that have been linked to cardiomyopathies and heart failure are the muscle-specific cytoskeletal IF protein desmin and the nuclear IF protein lamin, as a subgroup of the known desminopathies and laminopathies, respectively. The studies so far, both with healthy and diseased heart, have demonstrated the importance of these IF protein networks in intracellular and intercellular integration of structure and function, mechanotransduction and gene activation, cardiomyocyte differentiation and survival, mitochondrial homeostasis, and regulation of metabolism. The high coordination of all these processes is obviously of great importance for the maintenance of proper, life-lasting, and continuous contraction of this highly organized cardiac striated muscle and consequently a healthy heart. In this review, we will cover most known information on the role of IFs in the above processes and how their deficiency or disruption leads to cardiomyopathy and heart failure.

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Section: Contribution To Cardiac Fibrosis and Inflammationmentioning

confidence: 91%

Intermediate filaments in cardiomyopathy

et al. 2018

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“…1 The authors strongly disagree with our proposal that cystatin C (CysC) and galectin-3 (Gal-3) may be novel therapeutic targets in heart failure (HF), as we suggest in our recent article published in the journal. 2 In this study we showed that left atrial volume index was correlated with mitral regurgitant volume, plasma CysC and right ventricular systolic pressure in HF with severely impaired ejection fraction (HFrEF). Moreover, CysC was positively associated with circulating Gal-3, giving new insights to heart and kidney cross-talk.…”

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confidence: 89%

Cystatin C and galectin-3 as therapeutic targets in heart failure

Zivlas

Triposkiadis

Psarras

et al. 2018

Therapeutic Advances in Cardiovascular Disease

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“…Furthermore, Gal-3 is thought to be involved in the formation, destabilization, and rupture of plaques [87]. Serum Gal-3 is related to left ventricular dilation and is a contributory factor in predicting the outcome and guiding the monitoring of patients with both acute heart failure and chronic heart failure [88][89][90].…”

Section: Galectin-3 (Gal-3)mentioning

confidence: 99%

The Biomarkers for Acute Myocardial Infarction and Heart Failure

Wang

Zhang

et al. 2020

BioMed Research International

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The use of a large number of cardiovascular biomarkers, meant to complement the use of the electrocardiogram, echocardiography cardiac imaging, and clinical symptom assessment, has become a routine in clinical diagnosis, differential diagnosis, risk stratification, and prognosis and guides the management of patients with suspected cardiovascular diseases. There is a broad consensus that cardiac troponin and natriuretic peptides are the preferred biomarkers in clinical practice for the diagnosis of the acute coronary syndrome and heart failure, respectively, while the roles and possible clinical applications of several other potential biomarkers are still under study. This review mainly focuses on the recent studies of the roles and clinical applications of troponin and natriuretic peptides, which seem to be the best-validated markers in distinguishing and predicting the future cardiac events of patients with suspected cardiovascular diseases. Additionally, the review briefly discusses some of the large number of potential markers that may play a more prominent role in the future.

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Left atrial volume index in patients with heart failure and severely impaired left ventricular systolic function: the role of established echocardiographic parameters, circulating cystatin C and galectin-3

Abstract: Apart from known determinants of LAVi, circulating CysC and Gal-3 were associated with greater LA dilatation in patients with HF with reduced LVEF. Interestingly, the correlation between these two fibrotic proteins was positive.

Cited by 21 publications

References 44 publications

Intermediate filaments in cardiomyopathy

Intermediate filaments in cardiomyopathy

Cystatin C and galectin-3 as therapeutic targets in heart failure

The Biomarkers for Acute Myocardial Infarction and Heart Failure

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