Left Atrial Systolic Force in Asymptomatic Aortic Stenosis

Abstract

In patients with asymptomatic AS, LASF was closely related to filling pressure. Higher LASF invariably signifies the maximal LA effort to keep near normal LV filling pressure; lower LASF belongs to a heterogeneous group of patients in which it is much more difficult to depict who have low LA preload or who have intrinsic systolic LA dysfunction.

Left Atrial Work in Patients with Stable Chronic Heart Failure: Factors Associated and Prognostic Role

“…Similar results were found in other populations such as those of patients with aortic stenosis [19][20][21] or arterial hypertension, 22 where the prognostic power of a parameter of LA systolic performance as LA systolic force resulted as a stronger predictor of adverse CV events than LA size per se. Our results indicate that over 4.1 years the risk of CV death or hospitalization for HF is about 4 times higher in patients with CHF and abnormally high LAKE than CHF and normal LAKE.…”

Proper Use of Left Atrial Ejection Force as a Measure of Left Atrial Mechanical Function

“…We thank Zhong et al for their careful reading of our paper on left atrial systolic force in asymptomatic aortic stenosis 1 . We totally agree on the well‐known limitations of Manning's method, 2 including that (1) it is empirically based, (2) that measurement of the mitral orifice area and peak A velocity is performed at different levels, and (3) that the mitral annulus may often be more ellipsoid than circular.…”

“…We appreciate queries and comments raised by Dr. Zhong et al on our recently published study 1 . We also thank Dr. Zhong and his colleagues for their interest in our papers 1–3 . In a point wise fashion, we wish to discuss the queries raised by them.…”

“…Let us refer to two interesting recent articles on: (1) LASF in ASAS by Cioffi et al, 1 and (2) myocardial performance index and LAEF in patients with DMD by Shabanian et al 2 In both these articles, the formulation of LASF or LAEF is adopted from the earlier publication by Manning et al 3 …”

Left Atrial Volume as Predictor of Valve Replacement and Cardiovascular Events in Patients with Asymptomatic Mild to Moderate Aortic Stenosis

“…14 These findings may suggest that LA volume is an overall marker of the disease severity in AS and a relation to adverse events was expected. 23,24 However, the results of this study demonstrate that even though LA volume is enlarged in asymptomatic patients with mild to moderate disease, a single measure of LA volume is not an independent predictor of AVR or aortic valve related events several years later. This may be explained by the fact that there are several other reasons for increasing LA volume, which may not be strong predictors of valve related adverse events, including AVR.…”