Left atrial size and risk of recurrent ischemic stroke in cardiogenic cerebral embolism

Quan, Weiwei; Yang, Xiangdong; Li, Youyu; Li, Jia; Ye, Weiyi; Zhang, Ou; Zhang, Xu

doi:10.1002/brb3.1798

Cited by 6 publications

(5 citation statements)

References 30 publications

(63 reference statements)

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“…The inclusion criteria were as follows: (a) acute onset, confirmed by cranial CT or MRI, with AIS, and in line with the diagnostic criteria for CCE: Patients may be caused by emboli in the heart. (1) At least one related cardiac source of emboli must be determined; (2) clinical and neuroimaging findings are similar to LAA ischemic stroke; and (3) previous transient ischemic attack (TIA) or stroke in more than one vascular area or evidence of systemic embolism supports the clinical diagnosis of cardiogenic stroke (Quan et al., 2020; Sacco et al., 2013; “Stroke‐‐1989. Recommendations on stroke prevention, diagnosis, and therapy.…”

Section: Methodsmentioning

confidence: 99%

Early neurological deterioration in cardiogenic cerebral embolism due to nonvalvular atrial fibrillation: Predisposing factors and clinical implications

Liu

2020

Brain and Behavior

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Purpose The aim of the study was to investigate factors which may predispose patients to early neurological deterioration (END) and explore peripheral biomarkers for the prediction of END in cardiogenic cerebral embolism (CCE) patients. Methods Patients diagnosed with CCE within 24 hr of onset between January 2017 and January 2019 were included in this study. END was defined as an increase of ≥2 on the National Institutes of Health Stroke Scale (NIHSS) or the emergence of new neurological symptoms within 3 days of admission. Binary logistic regression was used to investigate the factors associated with END. Receiver operating characteristic (ROC) curves were then generated to determine the predictive value of the potential biomarkers and the optimal cutoff values. Results Of the 129 (male, 55.81%; mean age 71.85 ± 11.99 years) CCE patients, 55 patients with END were identified. Hemorrhage transformation (HT), coronary heart disease (CHD), diastolic blood pressure, cystatin C levels, NIHSS score, and platelet‐to‐lymphocyte ratio (PLR) at admission were independently associated with END. A peripheral cystatin C level ≥ 1.41 mg/L and a PLR ≥ 132.97 were predictive factors for END in CCE patients. The lymphocyte‐to‐monocyte ratio (LMR) was negatively independently associated with HT, and LMR < 2.31 may predict the occurrence of HT in patients with CCE. Conclusions Of the potential predisposing factors considered, increased cystatin C and PLR were associated with END within 3 days of CCE, and a decreased LMR may have predictive value for HT in CCE patients.

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Section: Methodsmentioning

confidence: 99%

Early neurological deterioration in cardiogenic cerebral embolism due to nonvalvular atrial fibrillation: Predisposing factors and clinical implications

Liu

2020

Brain and Behavior

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“…[31] LAE is not only an independent predictor of AF recurrence, [32][33][34] relevant literature also points out that LAE would increase the incidence of thrombus formation from the left atrial appendage(LAA) in patients with AF. [35] Impaired LV systolic and diastolic function are common clinical manifestations of patients after AMI. [36] LV contractility decreases, stroke volume decreases, and the echocardiogram shows a decrease in LVEF and fraction short (FS).…”

Section: Discussionmentioning

confidence: 99%

Left Atrial diameter Index as a prognostic factor for STEMI: a case-control study

Zhang¹,

Han²,

Chen³

et al. 2021

Preprint

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Background：The left atrium has a considerable role in cardiac function because of its unique anatomy and physiological function. We evaluated the role of the size of the left atrium in the prognosis of STEMI by quantifying the left atrium by introducing a left atrial diameter index(LAdI).Methods: This is a retrospective study conducted in a University Affiliated Hospital. Echocardiography is used to evaluate the size of left atrial diameter. It is indexed by body surface(BSA) area to evaluate the significance of LAdI on the prognosis of STEMI.This study was approved by the medical ethics committee of The First Hospital of Jilin University. All subjects in this trial gave written informed consent.Results: A total of 473 patients with a first STEMI within two years met the inclusion criteria to be included in this study. LA（OR=6.945；95%CI 1.398~34.499；P=0.018）and EF （OR=0.931；95%CI 0.904~0.960; P=0.000 ）were independent risk factors for MACEs.Conclusion:Patients with a first STEMI with a greater LAdI have a greater risk of MACEs than patients with a normal left atrium despite well-established PCI therapies.

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“…Some studies have pointed out that the onset of acute stroke can cause a strong stress response, activate the protective mechanism of the central nervous system in the body, and increase the body's BNP. The secretion of NT-proBNP is the cleavage product of BNP, and the two have extensive homology [ 11 ]. At the same time, the half-life of NT-proBNP is longer, and its detection sensitivity is loftier than that of BNP.…”

Section: Related Workmentioning

confidence: 99%

The Clinical Noteworthiness of Plasma NT‐ProBNP Standard in Sufferers with Cardiogenic Cerebral Embolism and Its Diagnostic Value for Such Sufferers

Shi

Liu

Li³

et al. 2022

Contrast Media & Molecular Imaging

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In order to explore the clinical noteworthiness of plasma NT-proBNP standards in sufferers with cardiogenic cerebral embolism and its diagnostic value for such sufferers, a retrospective study is conducted by the clinical data of sufferers with cerebral embolism. 100 sufferers with cerebral embolism admitted to our hospital from January 2018 to December 2020 are selected. According to the heparin-like drug therapy of acute ischemic stroke test (TOAST) classification criteria, they are divided into cardiac sufferers with cerebral embolism set (43 cases) and noncardiac cerebral embolism set (57 cases). The analysis results show the correlation between serum NT-proBNP standard and neurological impairment score. The detection of-proBNP standard can be used as a diagnostic indicator of disease severity and prognosis for sufferers with cardiogenic cerebral embolism.

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Left atrial size and risk of recurrent ischemic stroke in cardiogenic cerebral embolism

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 6 publications

References 30 publications

Early neurological deterioration in cardiogenic cerebral embolism due to nonvalvular atrial fibrillation: Predisposing factors and clinical implications

Early neurological deterioration in cardiogenic cerebral embolism due to nonvalvular atrial fibrillation: Predisposing factors and clinical implications

Left Atrial diameter Index as a prognostic factor for STEMI: a case-control study

The Clinical Noteworthiness of Plasma NT‐ProBNP Standard in Sufferers with Cardiogenic Cerebral Embolism and Its Diagnostic Value for Such Sufferers

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