Left atrial receptors and the antidiuretic hormone

Kappagoda, C. T.; Snow, H. M.; Whitaker, E. M.

doi:10.1113/jphysiol.1974.sp010503

Cited by 36 publications

(36 citation statements)

References 29 publications

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“…Thoren (1979) suggested that the atrial receptors attached to non-myelinated fibres in the vagi might be responsible for the reflex decrease in plasma vasopressin. His argument was based on the observation that distension of a large balloon in the lumen of the left atrium, which stimulates receptors attached to both myelinated and non-myelinated vagal afferent fibres, causes a decrease in plasma vasopressin (de Torrente, Robertson, McDonald & Schrier, 1975), whereas distension of the small balloons in the pulmonary vein -atrial junctions (Kappagoda et al 1974), stimulating predominantly receptors attached to myelinated fibres, did not cause a decrease in the antidiuretic activity of the plasma. The results of the present study do not support the above hypothesis that the atrial receptors attached to non-myelinated afferent vagal fibres are responsible for the decrease in plasma vasopressin.…”

Section: Resultsmentioning

confidence: 99%

The Atrial Receptors Responsible for the Decrease in Plasma Vasopressin Caused by Distension of the Left Atrium in the Dog

Bennett

Mary

1984

Exp Physiol

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SUMMARYIn dogs anaesthetized with chloralose, the effects of cooling the cervical vagi on the reflex decrease in plasma concentration of vasopressin, caused by distension of a large balloon in the lumen of the left atrium, were examined. Distension of the balloon in ten dogs with the vagi at 37°C resulted in a decrease in plasma concentration of vasopressin and, as before, an increase in urine flow. The responses were not significantly affected by cooling to 16-18°C but were abolished at 9 IC. At [16][17][18]

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Section: Resultsmentioning

confidence: 99%

The Atrial Receptors Responsible for the Decrease in Plasma Vasopressin Caused by Distension of the Left Atrium in the Dog

Bennett

Mary

1984

Exp Physiol

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“…not significant (Student's two-tailed, paired t test). fact that plasma obtained during the period of stimulation of atrial receptors did not inhibit urine flow in the water loaded ethanol anaesthetized rat (Kappagoda et al 1974).…”

Section: Discussionmentioning

confidence: 99%

Diuresis from left atrial receptors: effect of plasma on the secretion of the Malpighian tubules of Rhodnius prolixus.

Kappagoda¹,

Knapp²,

Pearson³

et al. 1979

The Journal of Physiology

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SUMMARY1. Stimulation of left atrial receptors by distension of a balloon in the lumen of the left atrium of anaesthetized dogs was shown to result in an increase in urine flow. Plasma samples obtained from these dogs during control periods and during periods of stimulation were applied to the Malpighian tubules of Rhodnius prolixus.2. It was found that the tubules suspended in test plasma secreted at a significantly lower rate than those suspended in control plasma.3. These differences were also evident in extracts of plasma prepared using the solvent n-butanol.4. Cutting or cooling the cervical vagi abolished these differences along with the increase in urine flow. It is argued that this preparation of the Malpighian tubule of Rhodnius prolixus could be used as a means of detecting the diuretic agent responsible for the increase in urine flow.

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“…The mechanism for this reflex appears to be mechanoreceptors situated in the cardiopulmonary area activating the vagal and/or sympathetic afferent fibers to control renal function. Although increases in renal excretory function have been repeatedly demonstrated by mechanical stretch of the atria (Lydtin and Hamilton, 1964;Linden, 1973;Goetz et al, 1975;Fater et al, 1982;Schultz et al, 1982), distention of the left atrium by balloon inflation (Ledsome et al, 1961;Kappagoda et al, 1974;Zehr et al, 1976), and volume expansion (Gilmore and Weisfeldt, 1965;Fater et al, 1982), it remains controversial whether the responses of renal function are mediated by vagal afferents. For example, Gilmore and Weisfeldt (1965) failed to demonstrate any difference in the natriuretic response of the kidney to acute volume expansion before and after bilateral vagotomy in the anesthetized dog.…”

Section: Discussionmentioning

confidence: 99%

Responses of renal hemodynamics and function to acute volume expansion in the conscious dog.

Sit¹,

Morita²,

Vatner³

1984

Circulation Research

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SUMMARY. The renal vascular and functional responses to acute volume expansion were determined in conscious dogs with all reflexes intact, sinoaortic arterial baroreceptor denervation, arterial baroreceptor denervation plus bilateral stellectomy, and arterial baroreceptor denervation plus bilateral vagotomy. In the intact dogs, when an isotonic saline infusion increased right atrial pressure by 6 mm Hg, arterial pressure increased by 15 ± 3 from 95 ± 3 mm Hg (P < 0.01) and heart rate rose from 87 ± 4 to 135 ± 6 beats/min (P < 0.01), while renal blood flow rose only slightly (4 ± 2%), and calculated renal resistance was not altered significantly. After arterial baroreceptor denervation, volume expansion with saline induced a greater rise in blood flow (16 ± 2 %), but did not alter arterial pressure, and calculated resistance fell by 19 ± 3% from 0.72 ± 0.05 mm Hg/ml per min (P < 0.01), while heart rate still increased. After arterial baroreceptor denervation and either bilateral stellectomy or vagotomy, volume expansion reduced renal vascular resistance by similar amounts. When intact animals were volume expanded by 20% of estimated blood volume with isooncotic, isotonic 3% dextran in saline solution, and with renal perfusion pressure held constant, central venous pressure increased by 4.5 ± 0.6 from 1.8 ± 0.4 mm Hg (P < 0.01), renal blood flow increased significantly by 16 ± 5 ml/min (P < 0.05) from 191 ± 30 ml/min, while calculated renal vascular resistance decreased significantly by 0.08 ± 0.02 from 0.62 ± 0.09 mm Hg/ml per min (P < 0.05). Average urine flow rate and sodium excretion 10-60 minutes after expansion increased markedly by 1.85 ± 0.27 ml/min and 9.84 ± 1.13 ^Eq/min per kg, respectively (P < 0.01). After arterial baroreceptor denervation, volume expansion induced a similar rise in central venous pressure and renal blood flow. The diuretic and natriuretic responses were not attenuated by arterial baroreceptor denervation. After arterial baroreceptor denervation plus bilateral vagotomy, there was a significant and similar rise in renal blood flow, whereas diuretic (urine flow rate rose by only 0.50 ± 0.10 from 0.35 ± 0.08 ml/min) and natriuretic (sodium excretion rose by only 4.83 ± 0.95 from 1.50 ± 0.48 ^Eq/min per kg) responses were significantly attenuated (P < 0.01). These data indicate that-in the intact conscious dog-vagal afferent mechanisms play an important role in mediating the diuretic and natriuretic responses to acute volume expansion, whereas the changes in renal hemodynamics that occur with volume expansion appear independent of reflex pathways. (Circ Res 54: 185-195, 1984)

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Left atrial receptors and the antidiuretic hormone

Cited by 36 publications

References 29 publications

The Atrial Receptors Responsible for the Decrease in Plasma Vasopressin Caused by Distension of the Left Atrium in the Dog

The Atrial Receptors Responsible for the Decrease in Plasma Vasopressin Caused by Distension of the Left Atrium in the Dog

Diuresis from left atrial receptors: effect of plasma on the secretion of the Malpighian tubules of Rhodnius prolixus.

Responses of renal hemodynamics and function to acute volume expansion in the conscious dog.

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