Left Atrial Dysfunction by Speckle Tracking Echocardiography in Young Subjects With Hiv Infection

Mirea, Oana; Donoiu, Ionuţ; Manescu, Mirela; Dumitrescu, Florentina; Istrătoaie, Octavian; Militaru, Constantin

doi:10.1016/j.ultrasmedbio.2022.04.032

Cited by 1 publication

(1 citation statement)

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“…Relatively few studies on this topic have been carried out, but there is emerging evidence to suggest its utility in the diagnosis of subclinical HIV-associated cardiovascular disease. (26,27) Biochemical cardiac markers are integral to the diagnosis and management of cardiovascular conditions. High sensitivity cardiac troponin T (hs-cTnT) and N-terminal proBNP (NT-proBNP) are well established markers that provide information on cardiac injury and myocardial stretch respectively.…”

Section: Remodelling In Hiv-infectionmentioning

confidence: 99%

Subclinical cardiovascular remodelling in HIV-infection: a multimodal descriptive study of two serodiscordant, monozygotic twins

Robbertse,

Steyn,

Rajah

et al. 2024

SAHJ

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Cardiovascular abnormalities have been demonstrated in people living with HIV at the time of HIV diagnosis, but pathology may be challenging to diagnose in the individual. To describe subtle cardiovascular remodelling and dysfunction in two identical twins, one without HIV and the other with a new diagnosis of HIV (serodiscordant). We hypothesise that a difference in cardiovascular parameters would not be demonstrable between the twins, unless non-genetic (environmental) factors were influencing the cardiovascular system. Significant cardiovascular differences likely represent occult pathology secondary to the effects of early HIV-infection, before the initiation of antiretroviral therapy. A 25-year-old female, incidentally diagnosed with HIV (CD4 count 513 cells/ml; estimated time of HIV infection 7-months), underwent cardiovascular magnetic resonance imaging, cardiac biomarker evaluation, and echocardiographic strain assessment. Her healthy, HIV-uninfected identical twin, living together since birth, underwent an identical assessment for comparison. Blinded measurements were performed.

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Section: Remodelling In Hiv-infectionmentioning

confidence: 99%