Left atrial appendage occlusion in a patient with hereditary hemorrhagic telangiectasia and atrial fibrillation – a therapeutic option worth considering

Mielczarek, Maksymilian; Gałąska, Rafał; Drewla, Piotr; Kulawiak-Gałąska, Dorota; Ciećwierz, Dariusz; Gruchała, Marcin

doi:10.5114/amsad.2017.68657

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“…In addition to these cases in PwH, there have been reports of successful LAA closure in patients with hereditary hemorrhagic telangiectasia. 12 , 13 …”

Section: Discussionmentioning

confidence: 99%

Apixaban and Eftrenonacog Alfa Treatment in a Patient with Moderate Hemophilia B and Cardiovascular Disease

2021

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In developed countries, the life expectancy of patients with hemophilia (PwH) is now close to that of the unaffected male population. This means that these patients are at risk of developing age-related comorbidities, including cardiovascular disease. Managing cardiovascular disease in PwH patients can be particularly challenging, due to their high bleeding risk. To our knowledge, this is the first report of a male patient with moderate hemophilia B and hypertensive ischemic heart disease complicated by arrhythmia due to nonvalvular atrial fibrillation, who was treated with apixaban and left atrial appendage closure while receiving concomitant anti-hemorrhagic prophylaxis with eftrenonacog alfa.

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“…In addition to these cases in PwH, there have been reports of successful LAA closure in patients with hereditary hemorrhagic telangiectasia. 12 , 13 …”

Section: Discussionmentioning

confidence: 99%