Left Atrial Appendage Occlusion Device and Novel Oral Anticoagulants Versus Warfarin for Stroke Prevention in Non-Valvular Atrial Fibrillation: A Systematic Review and Meta-Analysis of Randomized Control Trials

Briceño, David; Spinetto, Pedro Villablanca; Cyrille, Nicole; Massera, Daniele; Bader, Eric; Manheimer, Eric D.; Aagaard, Philip; Ferrick, Kevin J.; Gross, Jay N.; Kim, Soo Gyum; Krumerman, Andrew; Palma, Eugen C.; Guttenplan, Nils; Fisher, John D.; García, Mario J.; Biase, Luigi Di

doi:10.1016/s0735-1097(15)60304-7

Cited by 1 publication

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“…However, there are patients that present with thrombus formation in the LAA despite therapeutic anticoagulation . Left atrial appendage closure (LAAC) was demonstrated to be an alternative to OAC in selected patients . The presence of an LAA thrombus (LAAT) is however considered a contraindication to LAAC, therefore these patients were excluded from all major trials on LAAC.…”

Section: Introductionmentioning

confidence: 99%

“…3 Left atrial appendage closure (LAAC) was demonstrated to be an alternative to OAC in selected patients. 4 The presence of an LAA thrombus (LAAT) is however considered a contraindication to LAAC, therefore these patients were excluded from all major trials on LAAC. Earlier, we presented a case report of LAAC in a patient with a malignant thrombotic LAA formation refractory to multiple antithrombotic agents.…”

Section: Introductionmentioning

confidence: 99%

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Percutaneous left atrial appendage closure in the presence of thrombus: A feasibility report

Bordignon

Bologna

Chen

et al. 2019

Cardiovasc electrophysiol

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Background Patients with a left atrial appendage thrombus (LAAT) despite oral anticoagulation (OAC) are at high risk of thromboembolism (TE) and a relevant proportion of LAAT do not resolve under continued OAC. Left atrial appendage closure (LAAC) in the presence of LAAT was anecdotally described as a therapeutic option to prevent TE in the patients. Objective To describe the feasibility of LAAC despite LAAT in consecutive patients. Methods We searched the LAAC database of our center to identify patients in whom a LAAC was performed despite evidence of a thrombus in the LAA. All procedures were performed under transesophageal echocardiography guidance, no angiographies were performed to avoid LAAT dislocation. An Amulet Occluder device was preferred to allow proximal implantation and sealing of the LAA. Results Nine patients were identified. The mean age was 68.1 ± 10.7 years, four were female, mean CHADSVASC and HASBLED were 3.6 ± 1.7 and 3.0 ± 1.0. Eight of nine patients were on OAC, one patient was under lone aspirin therapy because of bleeding. The mean distance between the LAAT and the estimated landing zone was 18 ± 6 mm, the minimal distance was 11 mm. The mean landing zone was 21 ± 3 mm, devices with a mean size of 25 ± 4 mm were chosen for implantation. All implantation succeeded, only two patients required an intraprocedural replacement. No procedural complication nor short term thromboembolic complication during a follow up of 138 ± 149 days were recorded. Conclusion In the presented series a percutaneous LAAC despite a LAAT resulted to be feasible and safe.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%