Left and right ventricular diastolic functions in patients with rheumatoid arthritis without clinically evident cardiovascular disease

Rexhepaj, Nehat; Bajraktari, Gani; Berisha, Idriz; Beqiri, Arton; Shatri, Faik; F, Hima; Elezi, Shpend; Ndrepepa, Gjin

doi:10.1111/j.1368-5031.2006.00746.x

Cited by 46 publications

(13 citation statements)

References 24 publications

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“…Many echocardiographic studies have clearly demonstrated that diastolic dysfunction was common in patients with RA without heart disease. In one study, it was shown that diastolic function abnormalities in RA patients were correlated with the duration of the disease [29]. Di Franco and coworkers obtained similar results and speculated that the cause of diastolic function abnormalities in patients with RA was intrinsic myocardial abnormalities [30].…”

Section: Discussionmentioning

confidence: 91%

Frequency of fragmented QRS on ECG is increased in patients with rheumatoid arthritis without cardiovascular disease: a pilot study

et al. 2011

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Myocardial fibrosis causes the fragmentation of QRS complexes (fQRS) on ECGs. We hypothesized that the frequency of fQRS could be more common in patients with rheumatoid arthritis (RA) than in control subjects. A total of 56 patients with RA were compared with 35 age- and gender-matched fibromyalgia subjects for fQRS. The fQRS was defined as the presence of an additional R wave, or notching of the R or S wave, or the presence of fragmentation in 2 contiguous leads corresponding to the territory of a major coronary artery. Patients with bundle block on ECG and cardiovascular disease were excluded. Twenty-one patients (37.5%) in the RA group had fQRS, while two patients in the control group (5.7%) had fQRS (p = 0.001). No differences were found between the groups in terms of age, gender, or drug use. Duration of disease--years (interquartile range [IQR])--was 10 (8) in the fQRS (+) group, while it was 5 (2) in the fQRS (-) group (p < 0.001). Multivariate logistic regression analysis revealed that duration of disease was associated with the presence of fQRS (B = 1.5, odds ratio = 4.5, p = 0.004, 95% confidence interval = 1.6-12.7). We found that fQRS on ECG was more common in patients with RA without cardiovascular disease than in age- and gender-matched control subjects.

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Section: Discussionmentioning

confidence: 91%

Frequency of fragmented QRS on ECG is increased in patients with rheumatoid arthritis without cardiovascular disease: a pilot study

et al. 2011

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“…Seven out of 8 of the studies with a total of 2243 subjects investigated the correlation between diastolic dysfunction and the disease (RA) duration. 12 - 17 , 19 Most of the studies (6 out of 7 studies) demonstrated a significant inverse relationship between the E/A ratio and the disease duration. The only exception was a study by Montecucco et al, 16 which found no association between these 2 variables.…”

Section: Disease Durationmentioning

confidence: 99%

“…The only exception was a study by Montecucco et al, 16 which found no association between these 2 variables. We performed a pooled analysis using the data from 4 studies 12 , 14 , 17 , 19 in order to determine the relationship between the E/A ratio and disease duration. Three of the studies 13 , 15 , 16 were not included in the analysis as the values of the correlation coefficient (r) were not available.…”

Section: Disease Durationmentioning

confidence: 99%

Predictors of diastolic dysfunction in rheumatoid arthritis

Sakthiswary

Das

2015

SMJ

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The main objective was to determine the predictors of diastolic dysfunction in rheumatoid arthritis (RA). Articles pertaining to diastolic dysfunction in RA were retrieved from Scopus, EBSCO, PubMed, Web of Science, and Cochrane Library databases. Keywords such as: diastolic, cardiac, left ventricular function, heart failure, rheumatoid arthritis, and cardiac failure were used. Studies, which examined factors, or predictors of diastolic dysfunction in RA, and those with echocardiographic evaluation of diastolic dysfunction, were included. A total of 8 studies met the eligibility criteria. Most studies (6 out of 7 studies) demonstrated a significant inverse relationship between the E (early)/A (late) ratio and disease duration. The pooled analysis using the random effects model revealed a significant but weak inverse relationship between the ratio of the E to A ventricular filling velocities (E/A) ratio and the disease duration (p<0.05, r=-0.385). There was a significant relationship between E/A ratio and disease duration in RA.

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“…Представлено несколько работ по изучению ДД правого желудочка (ПЖ) при РА [14,[28][29][30][31]. ДД ПЖ CHF in Rheumatoid Arthritis Patients ХСН у больных ревматоидным артритом выявлена у 17 (23%) больных ранним РА и только в сочетании с ДД ЛЖ [14].…”

Section: эхокардиографические особенности диагностики хронической серunclassified

Chronic Heart Failure in Rheumatoid Arthritis Patients (Part II): Difficulties of Diagnosis

Новикова¹,

Udachkina²,

Kirillova³

et al. 2019

Racionalʹnaâ farmakoterapiâ v kardiologii

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Rheumatoid arthritis (RA) is characterized by a twofold increase in morbidity and mortality due to chronic heart failure (CHF). At the same time, the prevalence of CHF among RA patients is significantly underestimated. The aim of the review was to analyze the results of the main studies on the features of the clinical presentation of heart failure (HF) in RA patients, the role of visualization techniques and biomarkers in the diagnosis of HF and preclinical dysfunction of the myocardium. HF in patients with RA is characterized by a predominance of HF with a preserved left ventricular ejection fraction (LVEF). The use of clinical diagnostic criteria in RA patients can lead to both over- or underdiagnosis of CHF. Systolic dysfunction estimated by LVEF is rare in RA and does not reflect the real frequency of myocardial dysfunction. Echocardiography (ECHO-CG) with tissue Doppler echocardiography (TDE) and visualization of myocardial deformation, magnetic resonance imaging (MRI) of the heart in RA patients revealed a high frequency of HF with preserved ejection fraction, left ventricular remodeling and hypertrophy, pre-clinical systolic and diastolic dysfunction. Determination of natriuretic peptides is useful for verifying the diagnosis of HF and estimating the prognosis in this cohort, despite the possible decrease in the sensitivity and specificity of these indicators in RA patients. The review discusses the advantages of MRI of the heart, including quantitative T1 and T2 regimens, in the diagnosis of myocarditis, myocardial fibrosis, and myocardial perfusion disorders in RA patients. In order to verify the diagnosis of heart failure and detect pre-clinical myocardial dysfunction in RA patients, the determination of natriuretic peptides concentration should become part of the routine examination, beginning with the debut of the disease, along with the collection of a cardiological history, physical examination, ECHO-CT with TDE, and visualization of myocardial deformation. Evaluation of the quantitative characteristics of tissue according to MRI of the heart could improve the diagnosis of myocardial damage.

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Left and right ventricular diastolic functions in patients with rheumatoid arthritis without clinically evident cardiovascular disease

Cited by 46 publications

References 24 publications

Frequency of fragmented QRS on ECG is increased in patients with rheumatoid arthritis without cardiovascular disease: a pilot study

Frequency of fragmented QRS on ECG is increased in patients with rheumatoid arthritis without cardiovascular disease: a pilot study

Predictors of diastolic dysfunction in rheumatoid arthritis

Chronic Heart Failure in Rheumatoid Arthritis Patients (Part II): Difficulties of Diagnosis

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