Left and right basal ganglia and frontal activity during language 
generation: Contributions to lexical, semantic, and phonological 
processes

Crosson, Bruce; Benefield, Hope; Cato, M. Allison; Sadek, Joseph; Moore, Anna; Wierenga, Christina E.; Gopinath, Kaundinya; Soltysik, David A.; Bauer, Russell M.; Auerbach, Edward J.; Gökçay, Didem; Leonard, Christiana M.; Briggs, Richard W.

doi:10.1017/s135561770397010x

Cited by 163 publications

(127 citation statements)

References 55 publications

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“…The posterior regions of the brain activated in these tasks seem to have a relatively greater involvement in retrieval of stored information such as word meaning (BA21) (Demb et al, 1995;McDermott et al, 2003;Poldrack et al, 1999;Shivde & Thompson-Schill, 2004) or sound (BA7/40) (McDermott et al, 2003;Shivde & Thompson-Schill, 2004). Therefore, the findings on our activation maps correlate with the general knowledge about the distribution of the semantic and phonological networks in the brain (Crosson et al, 2003;Devlin et al, 2003;McDermott et al, 2003;Poldrack et al, 1999;Thompson-Schill et al, 1997).…”

Section: Discussionsupporting

confidence: 61%

“…However functional deficits are often associated with large lesions and make it difficult to relate specific deficits to specific anatomical regions. Evidence form neuroimaging studies complements the findings from brain damaged patients and makes it possible to identify specific brain areas associated with a specific task (Cabeza & Nyberg, 2000;Crosson et al, 2003;Devlin et al, 2003;Fiez & Petersen, 1998;Martin, 2003;McDermott et al, 2003;Poldrack et al, 1999;Price, 2000;Thompson-Schill et al, 1997). The findings of these studies revealed the existence of a vast network of brain structures that contribute to these language processes, including anterior and posterior, cortical and subcortical brain regions.…”

Section: Introductionmentioning

confidence: 87%

“…Subcortical structures have also been found to contribute to both semantic and phonological processing. Crosson et al (2003) showed that the left dorsal caudate and the ventral anterior thalamus contribute to retrieval of words from pre-existing lexical stores, due to direct connections with the pre-SMA. They have also suggested that right basal ganglia activity contributes by suppressing right frontal activity from interfering with language production.…”

Section: Introductionmentioning

confidence: 99%

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Functional connectivity in an fMRI study of semantic and phonological processes and the effect of l-Dopa

Tivarus¹,

Hillier²,

Schmalbrock³

et al. 2008

Brain and Language

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We describe an fMRI experiment examining the functional connectivity (FC) between regions of the brain associated with semantic and phonological processing. We wished to explore whether L-Dopa administration affects the interaction between language network components in semantic and phonological categorization tasks, as revealed by FC. We hypothesized that L-Dopa would decrease FC due to restriction of the semantic network. During two test sessions (placebo and L-Dopa) each participant performed two fMRI runs, involving phonological and semantic processing. A number of brain regions commonly activated by the two tasks were chosen: left inferior frontal, left posterior temporal and left fusiform gyri, and left parietal cortex. FC was calculated and further analyzed for effects of either the drug or task. No drug effect was found. A significant main effect for task was found, with a greater average correlation for the phonological task than for the semantic task. These findings suggest that language areas are activated in a more synchronous manner for phonological tasks than for semantic tasks. This may relate to the fact that phonological tasks are mediated to a greater extent within language areas, whereas semantic tasks likely require greater interaction outside of the language areas. Alternatively, this may be due to differences in the attentional requirements of the two tasks.

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Section: Discussionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Functional connectivity in an fMRI study of semantic and phonological processes and the effect of l-Dopa

Tivarus¹,

Hillier²,

Schmalbrock³

et al. 2008

Brain and Language

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“…Matsumoto et al (2004) suggested a possible indirect pathway between the left IFG and left pSTG/MTG via subcortical regions. An anatomical study in primates showed a pre-SMA projection to the head of the caudate [Inase et al, 1999]; this projection may form the pre-SMA-basal ganglia loop used in word generation [Crosson et al, 2003]. Previous studies based on an inherited speech disorder also suggested that an inferior frontal-basal ganglia loop is a critical neural circuit for speech production [Vargha-Khadem et al, 2005].…”

Section: Discussionmentioning

confidence: 98%

Neural correlates of noncanonical syntactic processing revealed by a picture‐sentence matching task

Kinno¹,

Kawamura²,

Shioda³

et al. 2007

Human Brain Mapping

106

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It remains controversial whether the left inferior frontal gyrus subserves syntactic processing or short-term memory demands. Here we devised a novel picture-sentence matching task involving Japanese sentences with different structures to clearly contrast syntactic reanalysis processes. Using event-related functional magnetic resonance imaging (fMRI), activations under three main conditions were directly compared: a canonical/subject-initial active sentence (AS), a noncanonical/subject-initial passive sentence (PS), and a noncanonical/object-initial scrambled sentence (SS). We found that activation in the dorsal region of the left inferior frontal gyrus (dF3t) was enhanced more by the noncanonical processing under the PS and SS conditions than by the canonical processing under the AS condition, and this enhancement was independent of domain-general factors, such as general memory demands and task difficulty. Moreover, the left posterior superior/middle temporal gyrus (pSTG/ MTG) showed more enhanced responses to object-initial sentences under the SS condition than to subject-initial sentences under the AS and PS conditions, which were not significantly affected by task difficulty. Furthermore, activation in the left lateral premotor cortex (LPMC) increased under the AS, PS, and SS conditions, in that order. It is possible that task difficulty affects the left LPMC, but the three distinct activations patterns suggest that these frontal and temporal regions work in concert to process syntactic structures, with their respective contributions dynamically regulated by linguistic requirements. Hum Brain Mapp 29: [1015][1016][1017][1018][1019][1020][1021][1022][1023][1024][1025][1026][1027] 2008. V V C 2007 Wiley-Liss, Inc.

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“…Alternatively, it is also possible that the observed effect on the right caudate nucleus is related instead to its role in speech production. For instance, Grogan et al (2009) observed that L2 phonemic fluency was associated with gray matter density in bilateral areas of the caudate nucleus, and Crosson et al (2003) observed significant activity in the right caudate nucleus during tasks requiring generation of words.…”

Section: Discussionmentioning

confidence: 99%

Bilingualism at the core of the brain. Structural differences between bilinguals and monolinguals revealed by subcortical shape analysis

et al. 2016

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Naturally acquiring a language shapes the human brain through a long-lasting learning and practice process. This is supported by previous studies showing that managing more than one language from early childhood has an impact on brain structure and function.However, to what extent bilingual individuals present neuroanatomical peculiarities at the subcortical level with respect to monolinguals is yet not well understood, despite the key role of subcortical gray matter for a number of language functions, including monitoring of speech production and language control -two processes especially solicited by bilinguals. Here we addressed this issue by performing a subcortical surfacebased analysis in a sample of monolinguals and simultaneous bilinguals (N=88) that only differed in their language experience from birth. This analysis allowed us to study with great anatomical precision the potential differences in morphology of key subcortical structures, namely, the caudate, accumbens, putamen, globus pallidus and thalamus.Vertexwise analyses revealed significantly expanded subcortical structures for bilinguals compared to monolinguals, localized in bilateral putamen and thalamus, as well as in the left globus pallidus and right caudate nucleus. A topographical interpretation of our results suggests that a more complex phonological system in bilinguals may lead to a greater development of a subcortical brain network involved in monitoring articulatory processes.

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Left and right basal ganglia and frontal activity during language generation: Contributions to lexical, semantic, and phonological processes

Cited by 163 publications

References 55 publications

Functional connectivity in an fMRI study of semantic and phonological processes and the effect of l-Dopa

Functional connectivity in an fMRI study of semantic and phonological processes and the effect of l-Dopa

Neural correlates of noncanonical syntactic processing revealed by a picture‐sentence matching task

Bilingualism at the core of the brain. Structural differences between bilinguals and monolinguals revealed by subcortical shape analysis

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