Leflunomide Induced DRESS Syndrome: A Case Report

Parajuli, Sudip; Chaudhary, Dhruv; Pandey, SS; Baral, Shailesh; Pokhrel, Dinesh Binod

doi:10.3126/njdvl.v10i1.6423

Cited by 5 publications

(4 citation statements)

References 3 publications

(4 reference statements)

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“…We had observed one case of DRESS syndrome that was caused by Leflunomide. DRESS syndrome caused by Leflunomide was also reported by Parajuli S et al 24 .…”

Section: Original Articlementioning

confidence: 56%

Cutaneous Adverse Drug reactions: A Four-Year Study from Western Nepal

Neupane

Basnet

2018

J. Gandaki Med. Coll. Nepal

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Background: Cutaneous adverse drug reactions (CADRs) range from minor reactions to several life threatening complications. Objectives: To study the clinical spectrum of cutaneous adverse drug reactions, determine the causative drugs responsible for the reactions and to assess the preventability.Methods: The study was carried out in the Department of Dermatology of Gandaki Medical College Teaching Hospital from June 2011 to June 2015. All the patients attending the Dermatology Outpatient Department and the patients admitted in the wards with suspected cutaneous adverse drug reactions to systemic drugs were included in the study. A detailed clinical history, including the history of drug intake was noted. Each case was assessed for its causality by using the WHO definitions. Data analysis was done using SPSS software.Results: There were 102 patients in total. The mean age of the patient was 32 ±15.7 years. Maximum patients belonged to the 21 to 30 years age group. There were 59 female patients and 43 male patients. Severe type of cutaneous adverse drug reactions was noted in 7.8% of patients. Antibiotics were responsible for most of the cutaneous adverse drug reactions. Cefixime was the most commonly incriminated drug. Exanthematous drug reaction was the most common type seen in 45%. Stevens-Johnson syndrome was the commonest type noted among the serious adverse drug reactions. Drug preventability was noted in 6% of patients.Conclusions: The commonest type of CADR noted was exanthematous type. Antibiotics were the commonest drug group involved in CADR. Six percent of CADR were preventable. J-GMC-N | Volume 11 | Issue 01 | January-June 2018, Page: 21-26

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“…We had observed one case of DRESS syndrome that was caused by Leflunomide. DRESS syndrome caused by Leflunomide was also reported by Parajuli S et al 24 .…”

Section: Original Articlementioning

confidence: 56%

Cutaneous Adverse Drug reactions: A Four-Year Study from Western Nepal

Neupane

Basnet

2018

J. Gandaki Med. Coll. Nepal

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“… 2 Though less common than other drugs, leflunomide as an offending agent in DRESS has been described in the literature. 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 Selected clinical characteristics of these cases are shown in Table I .…”

Section: Discussionmentioning

confidence: 99%

“…3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 Selected clinical characteristics of these cases are shown in Table I .…”

Section: Discussionmentioning

confidence: 99%

Treatment of prolonged drug reaction with eosinophilia and systemic symptoms syndrome with dupilumab using a molecularly-guided approach

Valido,

Patel,

Murphy

et al. 2024

JAAD Case Reports

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“… Drug rash with eosinophilia and systemic symptoms syndrome (DRESS syndrome) is a potentially life-threatening, drug-induced, multi-organ system reaction, the most frequently involved organ is liver, followed by the kidneys and lungs. 1 Early detection and diagnosis followed by withdrawal of the offending agent is vital to minimise the associated morbidity and mortality. A detailed drug history is vital to identify the causative drugs.…”

mentioning

confidence: 99%

Leflunomide Induced Atypical DRESS: A Case Report and Literature Review

Fatima¹,

Azimi

Ashwini³

et al. 2023

MJR

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Drug rash with eosinophilia and systemic symptoms syndrome (DRESS syndrome) is a potentially life-threatening, drug-induced, multi-organ system reaction, the most frequently involved organ is liver, followed by the kidneys and lungs. 1 Early detection and diagnosis followed by withdrawal of the offending agent is vital to minimise the associated morbidity and mortality. A detailed drug history is vital to identify the causative drugs. Although Spanish guidelines were developed by a panel of allergy specialists from the Drug Allergy Committee of the Spanish Society of Allergy and Clinical Immunology (SEAIC) and are available in literature from 2020, many clinicians are still unaware about the management of this syndrome. Framing national guidelines for the early diagnosis and Pharmaco-therapeutic management of DRESS will help the healthcare professionals to save the patients from unintended vulnerability. Leflunomide, a drug widely used in rheumatology and orthopaedics must be used with caution since it has the potential to cause DRESS syndrome. We report a case of a lady aged 32 years, presented to our hospital with a history of leflunomide intake and symptoms of DRESS.

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Leflunomide Induced DRESS Syndrome: A Case Report

Abstract: DOI: http://dx.doi.org/10.3126/njdvl.v10i1.6423 NJDVL 2012; 10(1): 46-48

Cited by 5 publications

References 3 publications

Cutaneous Adverse Drug reactions: A Four-Year Study from Western Nepal

Cutaneous Adverse Drug reactions: A Four-Year Study from Western Nepal

Treatment of prolonged drug reaction with eosinophilia and systemic symptoms syndrome with dupilumab using a molecularly-guided approach

Leflunomide Induced Atypical DRESS: A Case Report and Literature Review

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