Very recently, the D0 collaboration has reported the observation of a narrow structure, X(5568), in the decay process X(5568) → B 0 s π ± using the 10.4fb −1 data of pp collision at √ s = 1.96 TeV. This structure is of great interest since it is the first hadronic state with four different valence quark flavors, b, s, u, d. In this work, we investigate tetraquarks with four different quark flavors. Based on the diquark-antidiquark scheme, we study the spectroscopy of the tetraquarks with one heavy bottom/charm quark and three light quarks. We find that the lowest-lying S-wave state, a tetraquark with the flavor [su][bd] and the spin-parity J P = 0 + , is about 150 MeV higher than the X(5568). Further detailed experimental and theoretical studies of the spectrum, production and decays of tetraquark states with four different flavors in the future are severely needed towards a better understanding its nature and the classification of hadron exotic states.