Smart homes enhance energy efficiency without compromising residents’ comfort. To support smart home deployment and services, an IoT network must be established, while energy-management techniques must be applied to ensure energy efficiency. IoT networks must perpetually operate to ensure constant energy and indoor environmental monitoring. In this paper, an advanced sensor-agnostic plug-n-play prescriptive edge-to-edge IoT network management with micro-services is proposed, supporting also the semantic interoperability of multiple smart edge devices operating in the smart home network. Furthermore, IoT health-monitoring algorithms are applied to inspect network anomalies taking proper healing actions/prescriptions without the need to visit the residency. An autoencoder long short-term memory (AE-LSTM) is selected for detecting problematic situations, improving error prediction to 99.4%. Finally, indicative evaluation results reveal the mitigation of the IoT system breakdowns.