LED-induced Ru-photoredox Pd-catalyzed C–H arylation of (6-phenylpyridin-2-yl)pyrimidines and heteroaryl counterparts

Antoniou, Ioakeim M.; Ioannou, Natalia; Panagiotou, Nikos; Georgiades, Savvas N.

doi:10.1039/d4ra02173h

RSC Adv.

2024

DOI: 10.1039/d4ra02173h

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LED-induced Ru-photoredox Pd-catalyzed C–H arylation of (6-phenylpyridin-2-yl)pyrimidines and heteroaryl counterparts

Ioakeim M. Antoniou,

Natalia Ioannou,

Nikos Panagiotou

et al.

Abstract: A LED-induced Ru-photoredox Pd-catalyzed method was employed to carry out late-stage C–H arylation on a series of Biginelli/Suzuki-derived modular (6-phenylpyridin-2-yl)pyrimidine substrates and their heteroaryl counterparts.

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Simple Access to 3-(Hetero)arylated Derivatives of 2-Furoic Acid via Ru(II)-Catalyzed C3-H Arylation of 2-Furoylimidazole

Chernyshev,

Ananikov,

Shepelenko

et al. 2024

Synthesis

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A new approach for the preparation of a variety of 3-arylated 2-furoic acid derivatives has been developed. The approach involves selective Ru-catalyzed C3-H arylation of the furan moiety of readily available 2-furoyl-1-methylimidazole (using imidazole as a removable N-donor directing group), subsequent N-methylation, and nucleophilic substitution of the imidazole moiety with N, O, S, and C nucleophiles.

show abstract

Simple Access to 3-(Hetero)arylated Derivatives of 2-Furoic Acid via Ru(II)-Catalyzed C3-H Arylation of 2-Furoylimidazole

Chernyshev,

Ananikov,

Shepelenko

et al. 2024

Synthesis

View full text Add to dashboard Cite

show abstract

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LED-induced Ru-photoredox Pd-catalyzed C–H arylation of (6-phenylpyridin-2-yl)pyrimidines and heteroaryl counterparts

Abstract: A LED-induced Ru-photoredox Pd-catalyzed method was employed to carry out late-stage C–H arylation on a series of Biginelli/Suzuki-derived modular (6-phenylpyridin-2-yl)pyrimidine substrates and their heteroaryl counterparts.

Cited by 1 publication

References 85 publications

Simple Access to 3-(Hetero)arylated Derivatives of 2-Furoic Acid via Ru(II)-Catalyzed C3-H Arylation of 2-Furoylimidazole

Simple Access to 3-(Hetero)arylated Derivatives of 2-Furoic Acid via Ru(II)-Catalyzed C3-H Arylation of 2-Furoylimidazole

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