LED-Based Optical Device for Chronic <i>In Vivo</i> Cerebral Blood Volume Measurement

Cox, Marshall; Ma, Hongtao; Bahlke, Matthias E.; Beck, Jonathan H.; Schwartz, Theodore H.; Kymissis, Ioannis

doi:10.1109/ted.2009.2033652

Cited by 8 publications

(7 citation statements)

References 9 publications

(15 reference statements)

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“…The pre-ictal optical signals we describe here may provide an alternative method. Additionally, the optical method is an non-invasive measurement, which can avoid the brain damage caused by implanted electrodes 9 . New neuroimaging and neuro-modulatory techniques such as 'optogenetics', which combines optical and genetic techniques, have emerged as a popular tool to probe and control neuronal function with light 1,4,5,54,55 .…”

Section: Discussionmentioning

confidence: 99%

Imaging preictal hemodynamic changes in neocortical epilepsy

Patel

Zhao²,

Ma³

et al. 2013

FOC

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Object The ability to predict seizure occurrence is extremely important to trigger abortive therapies and to warn patients and their caregivers. Optical imaging of hemodynamic parameters such as blood flow, blood volume, and tissue and hemoglobin oxygenation has already been shown to successfully localize epileptic events with high spatial and temporal resolution. The ability to actually predict seizure occurrence using hemodynamic parameters is less well explored. Methods In this article, the authors critically review data from the literature on neocortical epilepsy and optical imaging, and they discuss the preictal hemodynamic changes and their application in neurosurgery. Results Recent optical mapping studies have demonstrated preictal hemodynamic changes in both human and animal neocortex. Conclusions Optical measurements of blood flow and oxygenation may become increasingly important for predicting and localizing epileptic events. The ability to successfully predict ictal onsets may be useful to trigger closed-loop abortive therapies.

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Section: Discussionmentioning

confidence: 99%

Imaging preictal hemodynamic changes in neocortical epilepsy

Patel

Zhao²,

Ma³

et al. 2013

FOC

Self Cite

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“…An optical fiber SPR system can detect reactions of living cells attached to the fiber tip in a real-time manner, and human blood-group detections have been carried out by SPR with high accuracy [27,28]. Other biomedical devices like ring-shaped photodiode fabricated and mounted on a printed circuit board for pulse oximetry measurements and optical sensors used miniature LEDs for cerebral blood volume measurement are both novel and useful [29,30].…”

Section: Noveltymentioning

confidence: 99%

Biomedical sensor technologies on the platform of mobile phones

Liu

2011

Front. Mech. Eng.

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“…Green and red infrared lights are often used, and the penetration depth is less than 1 mm and about 2.5 mm, respectively [ 14 , 16 , 17 ]. In studies of cortical cryptogenic epilepsy, some researchers have studied a LED-based optical device suitable for implantation to detect blood volume changes in the brain associated with epilepsy [ 18 , 19 ]. It was combined with ECoG to locate lesions and verified its feasibility for in vivo experiments [ 18 , 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…In studies of cortical cryptogenic epilepsy, some researchers have studied a LED-based optical device suitable for implantation to detect blood volume changes in the brain associated with epilepsy [ 18 , 19 ]. It was combined with ECoG to locate lesions and verified its feasibility for in vivo experiments [ 18 , 20 , 21 ]. The size of this device is 2 mm × 2 mm × 0.8 mm.…”

Section: Introductionmentioning

confidence: 99%

Multimodal Detection for Cryptogenic Epileptic Seizures Based on Combined Micro Sensors

Shen

Jiao

et al. 2020

BioMed Research International

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The cryptogenic epilepsy of the neocortex is a disease in which the seizure is accompanied by intense cerebral nerve electrical activities but the lesions are not observed. It is difficult to locate disease foci. Electrocorticography (ECoG) is one of the gold standards in seizure focus localization. This method detects electrical signals, and its limitations are inadequate resolution which is only 10 mm and lack of depth information. In order to solve these problems, our new method with implantable micro ultrasound transducer (MUT) and photoplethysmogram (PPG) device detects blood changes to achieve higher resolution and provide depth information. The basis of this method is the neurovascular coupling mechanism, which shows that intense neural activity leads to sufficient cerebral blood volume (CBV). The neurovascular coupling mechanism established the relationship between epileptic electrical signals and CBV. The existence of mechanism enables us to apply our new methods on the basis of ECoG. Phantom experiments and in vivo experiments were designed to verify the proposed method. The first phantom experiments designed a phantom with two channels at different depths, and the MUT was used to detect the depth where the blood concentration changed. The results showed that the MUT detected the blood concentration change at the depth of 12 mm, which is the position of the second channel. In the second phantom experiments where a PPG device and MUT were used to monitor the change of blood concentration in a thick tube, the results showed that the trend of superficial blood concentration change provided by the PPG device is the same as that provided by the MUT within the depth of 2.5 mm. Finally, in the verification of in vivo experiments, the blood concentration changes on the surface recorded by the PPG device and the changes at a certain depth recorded by the MUT all matched the seizure status shown by ECoG. These results confirmed the effectiveness of the combined micro sensors.

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LED-Based Optical Device for Chronic In Vivo Cerebral Blood Volume Measurement

Cited by 8 publications

References 9 publications

Imaging preictal hemodynamic changes in neocortical epilepsy

Imaging preictal hemodynamic changes in neocortical epilepsy

Biomedical sensor technologies on the platform of mobile phones

Multimodal Detection for Cryptogenic Epileptic Seizures Based on Combined Micro Sensors

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