Lectures on Diseases of the Skin.

Wilson, Erasmus

doi:10.1016/s0140-6736(00)59951-6

Cited by 1 publication

(5 citation statements)

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“…[32] Wilson first described AA as "accidental alopecia." [33] Later, he used the term "porrigo decalvans," [34] but "accidental alopecia" and "alopecia accidentalis" were used in several 19th-century publications. While the approach is not perfect, [35] using "Google Ngrams viewer," [36] one can see use of the term "porrigo decalvans" declined, while "alopecia areata" gradually gained acceptance from the 1850s onwards ( Figure 1B).…”

Section: What ' S In a Name?mentioning

confidence: 99%

“…[17] 1841 Erasmus Wilson, in one of four Lectures on diseases of the skin, makes the first recorded mention of inflammation in relation to AA, along with defective nutrition due to poor capillary supply. [33] 1843 David Gruby publishes the first investigation demonstrating presence of "Microsporum audouini" around the hairs in AA patients and outlines the infectious agent hypothesis to explain AA pathogenesis. [32] 1847 Pierre Louis Alphée Cazenave publishes the first description of an association between AA and vitiligo; at the time thought to be of nervous origin.…”

Section: Bcementioning

confidence: 99%

“…[57] In the 19th century, later editions of Bateman's book "on Skin Diseases" suggested treatment by shaving, using friction, and oil of Mace dissolved in alcohol or prepared with tar oil, bitumen, camphor or turpentine. [58] Wilson recommended cantharides and lavender oil, [33] or iodine and antimony. Fox endorsed mercury ointment.…”

Section: Tre Atments For Alopecia Are Atamentioning

confidence: 99%

“…Or alternatively, iodine and antimony, for AA. [33,215] 1864 Watson reports on the use of carbolic acid to treat AA topically, as well as iron and quinine supplements orally. [216] 1873 Fox endorses mercury ointment and cantharides for AA.…”

Section: Bcementioning

confidence: 99%

“…The earliest mention of inflammation in relation to AA in "modern" medical literature came from Wilson (1840) who very briefly suggested that the local cause of AA was defective nutrition due to poor capillary supply, or inflammation. [33] The first evidence for inflammatory cells in and around hair follicles was produced from a postmortem histological analysis of scalp skin. [127] Surprisingly, despite observing leucocytes, and publishing the first drawing of hair follicle histology with inflammation, the authors dismissed their remark and focused on nerve atrophy.…”

Section: Alopecia Are Ata a S An Infl Ammatory Disordermentioning

confidence: 99%

See 4 more Smart Citations

A “hair‐raising” history of alopecia areata

Broadley

McElwee

2020

Experimental Dermatology

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A 3500‐year‐old papyrus from ancient Egypt provides a list of treatments for many diseases including “bite hair loss,” most likely alopecia areata (AA). The treatment of AA remained largely unchanged for over 1500 years. In 30 CE, Celsus described AA presenting as scalp alopecia in spots or the “windings of a snake” and suggested treatment with caustic compounds and scarification. The first “modern” description of AA came in 1813, though treatment still largely employed caustic agents. From the mid‐19th century onwards, various hypotheses of AA development were put forward including infectious microbes (1843), nerve defects (1858), physical trauma and psychological stress (1881), focal inflammation (1891), diseased teeth (1902), toxins (1912) and endocrine disorders (1913). The 1950s brought new treatment developments with the first use of corticosteroid compounds (1952), and the first suggestion that AA was an autoimmune disease (1958). Research progressively shifted towards identifying hair follicle‐specific autoantibodies (1995). The potential role of lymphocytes in AA was made implicit with immunohistological studies (1980s). However, studies confirming their functional role were not published until the development of rodent models (1990s). Genetic studies, particularly genome‐wide association studies, have now come to the forefront and open up a new era of AA investigation (2000s). Today, AA research is actively focused on genetics, the microbiome, dietary modulators, the role of atopy, immune cell types in AA pathogenesis, primary antigenic targets, mechanisms by which immune cells influence hair growth, and of course the development of new treatments based on these discoveries.

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Section: What ' S In a Name?mentioning

confidence: 99%

Section: Bcementioning

confidence: 99%

Section: Tre Atments For Alopecia Are Atamentioning

confidence: 99%